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- W2058133056 abstract "Plaque disruption with initiation of the thrombotic processes is generally accepted to be the main cause of acute coronary syndromes and acute myocardial infarction (AMI) [1,2]. Atherosclerotic lesions have been shown to contain large amounts of tissue factor (TF), a dominant initiator of the coagulation cascade. TF expression can be induced by a variety of stimuli in different cell types, like smooth muscle cells, monocytes and macrophages [3]. It has been shown that TF is expressed to a greater extent in coronary specimens from patients with acute coronary syndromes compared to those from stable angina pectoris patients [4,5]. Trace amounts of TF are present as soluble forms in plasma (sTF) [6]. Higher levels of sTF have been found in patients with AMI and unstable angina compared to patients with stable angina and controls [7,8]. Although the origin of sTF is unclear, these levels may reflect the TF expression within the vasculature and/or circulating cells. The aim of the present study was to investigate the relationship between the levels of sTF and future clinical events during a 4-year follow-up period in patients after an AMI." @default.
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- W2058133056 date "2003-01-01" @default.
- W2058133056 modified "2023-09-27" @default.
- W2058133056 title "Soluble tissue factor as predictor of future events in patients with acute myocardial infarction" @default.
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- W2058133056 doi "https://doi.org/10.1016/j.thromres.2003.09.019" @default.
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