FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058138322> ?p ?o ?g. }

• W2058138322 endingPage "38" @default.
• W2058138322 startingPage "28" @default.
• W2058138322 abstract "Transferrins, found in invertebrates and vertebrates, form a physiologically important family of proteins playing a major role in iron acquisition and transport, defense against microbial pathogens, growth and differentiation. These proteins are bilobal in structure and each lobe is composed of two domains divided by a cleft harboring an iron atom. Vertebrate transferrins comprise of serotransferrins, lactoferrins and ovotransferrins. In mammals serotransferrins transport iron in physiological fluids and deliver it to cells, while lactoferrins scavenge iron, limiting its availability to invading microbes. In oviparous vertebrates there is only one transferrin gene, expressed either in the liver to be delivered to physiological fluids as serotransferrin, or in the oviduct with a final localization in egg white as ovotransferrin. Being products of one gene sero- and ovotransferrin are identical at the amino-acid sequence level but with different, cell specific glycosylation patterns. Our knowledge of the mechanisms of transferrin iron binding and release is based on sequence and structural data obtained for human serotransferrin and hen and duck ovotransferrins. No sequence information about other ovotransferrins was available until our recent publication of turkey, ostrich, and red-eared turtle (TtrF) ovotransferrin mRNA sequences [Ciuraszkiewicz, J., Olczak, M., Wątorek, W., 2006. Isolation, cloning and sequencing of transferrins from red-eared turtle, African ostrich and turkey. Comp. Biochem. Physiol. 143 B, 301–310]. In the present paper, ten new reptilian mRNA transferrin sequences obtained from the Nile crocodile (NtrF), bearded dragon (BtrF), Cuban brown anole (AtrF), veiled and Mediterranean chameleons (VtrF and KtrF), sand lizard (StrF), leopard gecko (LtrF), Burmese python (PtrF), African house snake (HtrF), and grass snake (GtrF) are presented and analyzed. Nile crocodile and red-eared turtle transferrins have a disulphide bridge pattern identical to known bird homologues. A partially different disulphide bridge pattern was found in the Squamata (snakes and lizards). The possibility of a unique interdomain disulphide bridge was predicted for LtrF. Differences were found in iron-binding centers from those of previously known transferrins. Substitutions were found in the iron-chelating residues of StrF and TtrF and in the synergistic anion-binding residues of NtrF. In snakes, the transferrin (PtrF, HtrF and GtrF) N-lobe “dilysine trigger” occurring in all other known transferrins was not found, which indicates a different mechanism of iron release." @default.
• W2058138322 created "2016-06-24" @default.
• W2058138322 creator A5011897079 @default.
• W2058138322 creator A5015992805 @default.
• W2058138322 creator A5020453824 @default.
• W2058138322 creator A5060300980 @default.
• W2058138322 creator A5077371411 @default.
• W2058138322 creator A5078768895 @default.
• W2058138322 date "2007-07-01" @default.
• W2058138322 modified "2023-09-26" @default.
• W2058138322 title "Reptilian transferrins: Evolution of disulphide bridges and conservation of iron-binding center" @default.
• W2058138322 cites W102489613 @default.
• W2058138322 cites W1442483700 @default.
• W2058138322 cites W1535633114 @default.
• W2058138322 cites W1603634749 @default.
• W2058138322 cites W184834241 @default.
• W2058138322 cites W1964033920 @default.
• W2058138322 cites W1965040653 @default.
• W2058138322 cites W1968168983 @default.
• W2058138322 cites W1972584945 @default.
• W2058138322 cites W1972871186 @default.
• W2058138322 cites W1973551683 @default.
• W2058138322 cites W1975380286 @default.
• W2058138322 cites W1981440436 @default.
• W2058138322 cites W1982831087 @default.
• W2058138322 cites W1983891046 @default.
• W2058138322 cites W1985044177 @default.
• W2058138322 cites W1987227349 @default.
• W2058138322 cites W1991967206 @default.
• W2058138322 cites W2001776577 @default.
• W2058138322 cites W2004067151 @default.
• W2058138322 cites W2007234533 @default.
• W2058138322 cites W2008002182 @default.
• W2058138322 cites W2012873773 @default.
• W2058138322 cites W2015642465 @default.
• W2058138322 cites W2019410563 @default.
• W2058138322 cites W2021113388 @default.
• W2058138322 cites W2024563799 @default.
• W2058138322 cites W2027981940 @default.
• W2058138322 cites W2033249426 @default.
• W2058138322 cites W2042718474 @default.
• W2058138322 cites W2042980892 @default.
• W2058138322 cites W2048285411 @default.
• W2058138322 cites W2054205716 @default.
• W2058138322 cites W2056182743 @default.
• W2058138322 cites W2057081312 @default.
• W2058138322 cites W2066548059 @default.
• W2058138322 cites W2067384709 @default.
• W2058138322 cites W2069388625 @default.
• W2058138322 cites W2074611806 @default.
• W2058138322 cites W2078584920 @default.
• W2058138322 cites W2082056887 @default.
• W2058138322 cites W2087517456 @default.
• W2058138322 cites W2088644575 @default.
• W2058138322 cites W2106751755 @default.
• W2058138322 cites W2106882534 @default.
• W2058138322 cites W2108156627 @default.
• W2058138322 cites W2111409037 @default.
• W2058138322 cites W2121815724 @default.
• W2058138322 cites W2125036863 @default.
• W2058138322 cites W2127742502 @default.
• W2058138322 cites W2153994323 @default.
• W2058138322 cites W2161746138 @default.
• W2058138322 cites W2310237786 @default.
• W2058138322 doi "https://doi.org/10.1016/j.gene.2007.02.018" @default.
• W2058138322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17466466" @default.
• W2058138322 hasPublicationYear "2007" @default.
• W2058138322 type Work @default.
• W2058138322 sameAs 2058138322 @default.
• W2058138322 citedByCount "23" @default.
• W2058138322 countsByYear W20581383222012 @default.
• W2058138322 countsByYear W20581383222013 @default.
• W2058138322 countsByYear W20581383222014 @default.
• W2058138322 countsByYear W20581383222016 @default.
• W2058138322 countsByYear W20581383222017 @default.
• W2058138322 countsByYear W20581383222018 @default.
• W2058138322 countsByYear W20581383222020 @default.
• W2058138322 countsByYear W20581383222021 @default.
• W2058138322 crossrefType "journal-article" @default.
• W2058138322 hasAuthorship W2058138322A5011897079 @default.
• W2058138322 hasAuthorship W2058138322A5015992805 @default.
• W2058138322 hasAuthorship W2058138322A5020453824 @default.
• W2058138322 hasAuthorship W2058138322A5060300980 @default.
• W2058138322 hasAuthorship W2058138322A5077371411 @default.
• W2058138322 hasAuthorship W2058138322A5078768895 @default.
• W2058138322 hasConcept C104317684 @default.
• W2058138322 hasConcept C167625842 @default.
• W2058138322 hasConcept C22814914 @default.
• W2058138322 hasConcept C2777313579 @default.
• W2058138322 hasConcept C2780223390 @default.
• W2058138322 hasConcept C55493867 @default.
• W2058138322 hasConcept C86803240 @default.
• W2058138322 hasConceptScore W2058138322C104317684 @default.
• W2058138322 hasConceptScore W2058138322C167625842 @default.
• W2058138322 hasConceptScore W2058138322C22814914 @default.
• W2058138322 hasConceptScore W2058138322C2777313579 @default.
• W2058138322 hasConceptScore W2058138322C2780223390 @default.
• W2058138322 hasConceptScore W2058138322C55493867 @default.

• next