FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058138369> ?p ?o ?g. }

• W2058138369 endingPage "354" @default.
• W2058138369 startingPage "345" @default.
• W2058138369 abstract "Hepatobiliary transporters are down-regulated in toxic and cholestatic liver injury. Cytokines such as tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta) are attributed to mediate this regulation, but their particular contribution in vivo is still unknown. Thus, we studied the molecular mechanisms by which Ntcp, Oatp1, Oatp2, and Mrp2 are regulated by proinflammatory cytokines during liver injury. Rats were injected intraperitoneally with either carbon tetrachloride or endotoxin. Inactivation of TNF-alpha and IL-1 beta was achieved by repetitive intraperitoneal injection of etanercept and anakinra, respectively. Messenger RNA (mRNA) levels of transporters and binding activities as well as nuclear protein levels of Ntcp, Oatp2, and Mrp2 transactivators were determined 20 to 24 hours later. In contrast to IL-1 beta, TNF-alpha inactivation alone fully prevented down-regulation of Ntcp, Oatp1, and Oatp2 mRNA as well as reduced binding activity of hepatocyte nuclear factor 1 (HNF-1) in CCl(4)-induced toxic injury. In endotoxemia, down-regulation of Mrp2, and partially in case of Ntcp, could be prevented by IL-1 beta but not TNF-alpha blockade. However, inactivation of either cytokine led to preservation of HNF1 and partially of retinoid X receptor/retinoic acid receptor (RXR/RAR) binding activity. No effect of anticytokines was seen on pregnane X receptor (PXR) and constitutive androstane receptor (CAR) binding activity as well as nuclear protein mass. In conclusion, TNF-alpha represents the master cytokine responsible for HNF1-dependent down-regulation of Ntcp, Oatp1, and Oatp2 in CCl(4)-induced toxic liver injury. IL-1 beta predominates in a complex signaling network of Ntcp and Mrp2 regulation in cholestatic liver injury. In contrast to in vitro studies, HNF1 and RXR/RAR-independent mechanisms appear to be more important in regulation of Mrp2 and Ntcp gene expression in endotoxemia." @default.
• W2058138369 created "2016-06-24" @default.
• W2058138369 creator A5050470043 @default.
• W2058138369 date "2003-08-01" @default.
• W2058138369 modified "2023-10-15" @default.
• W2058138369 title "Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis" @default.
• W2058138369 cites W1550637999 @default.
• W2058138369 cites W1631557674 @default.
• W2058138369 cites W1978412289 @default.
• W2058138369 cites W1994056027 @default.
• W2058138369 cites W1994231705 @default.
• W2058138369 cites W1996011325 @default.
• W2058138369 cites W1997349791 @default.
• W2058138369 cites W2002216094 @default.
• W2058138369 cites W2004253721 @default.
• W2058138369 cites W2016351055 @default.
• W2058138369 cites W2017698887 @default.
• W2058138369 cites W2019757774 @default.
• W2058138369 cites W2021444563 @default.
• W2058138369 cites W2026160870 @default.
• W2058138369 cites W2029303787 @default.
• W2058138369 cites W2029816994 @default.
• W2058138369 cites W2030910975 @default.
• W2058138369 cites W2031580730 @default.
• W2058138369 cites W2031902074 @default.
• W2058138369 cites W2034040273 @default.
• W2058138369 cites W2035000881 @default.
• W2058138369 cites W2035370647 @default.
• W2058138369 cites W2037297309 @default.
• W2058138369 cites W2040822561 @default.
• W2058138369 cites W2044426721 @default.
• W2058138369 cites W2046211558 @default.
• W2058138369 cites W2046831425 @default.
• W2058138369 cites W2055461009 @default.
• W2058138369 cites W2065279732 @default.
• W2058138369 cites W2067603487 @default.
• W2058138369 cites W2079458953 @default.
• W2058138369 cites W2082168419 @default.
• W2058138369 cites W2082870822 @default.
• W2058138369 cites W2085122621 @default.
• W2058138369 cites W2100837269 @default.
• W2058138369 cites W2109915311 @default.
• W2058138369 cites W2125457175 @default.
• W2058138369 cites W2128194105 @default.
• W2058138369 cites W2131238799 @default.
• W2058138369 cites W2158028015 @default.
• W2058138369 cites W2160486989 @default.
• W2058138369 cites W2313990166 @default.
• W2058138369 cites W2402285268 @default.
• W2058138369 cites W2420331100 @default.
• W2058138369 cites W4293201222 @default.
• W2058138369 cites W4293247451 @default.
• W2058138369 doi "https://doi.org/10.1053/jhep.2003.50317" @default.
• W2058138369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12883478" @default.
• W2058138369 hasPublicationYear "2003" @default.
• W2058138369 type Work @default.
• W2058138369 sameAs 2058138369 @default.
• W2058138369 citedByCount "190" @default.
• W2058138369 countsByYear W20581383692012 @default.
• W2058138369 countsByYear W20581383692013 @default.
• W2058138369 countsByYear W20581383692014 @default.
• W2058138369 countsByYear W20581383692015 @default.
• W2058138369 countsByYear W20581383692016 @default.
• W2058138369 countsByYear W20581383692017 @default.
• W2058138369 countsByYear W20581383692018 @default.
• W2058138369 countsByYear W20581383692019 @default.
• W2058138369 countsByYear W20581383692020 @default.
• W2058138369 countsByYear W20581383692021 @default.
• W2058138369 countsByYear W20581383692022 @default.
• W2058138369 countsByYear W20581383692023 @default.
• W2058138369 crossrefType "journal-article" @default.
• W2058138369 hasAuthorship W2058138369A5050470043 @default.
• W2058138369 hasBestOaLocation W20581383691 @default.
• W2058138369 hasConcept C104317684 @default.
• W2058138369 hasConcept C126322002 @default.
• W2058138369 hasConcept C132040763 @default.
• W2058138369 hasConcept C134018914 @default.
• W2058138369 hasConcept C149011108 @default.
• W2058138369 hasConcept C164027704 @default.
• W2058138369 hasConcept C17991360 @default.
• W2058138369 hasConcept C185592680 @default.
• W2058138369 hasConcept C193264327 @default.
• W2058138369 hasConcept C2776637226 @default.
• W2058138369 hasConcept C2776914184 @default.
• W2058138369 hasConcept C36201501 @default.
• W2058138369 hasConcept C44312359 @default.
• W2058138369 hasConcept C55493867 @default.
• W2058138369 hasConcept C63932345 @default.
• W2058138369 hasConcept C71924100 @default.
• W2058138369 hasConcept C86339819 @default.
• W2058138369 hasConcept C86803240 @default.
• W2058138369 hasConcept C98274493 @default.
• W2058138369 hasConceptScore W2058138369C104317684 @default.
• W2058138369 hasConceptScore W2058138369C126322002 @default.
• W2058138369 hasConceptScore W2058138369C132040763 @default.
• W2058138369 hasConceptScore W2058138369C134018914 @default.
• W2058138369 hasConceptScore W2058138369C149011108 @default.
• W2058138369 hasConceptScore W2058138369C164027704 @default.

• next