FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058149739> ?p ?o ?g. }

• W2058149739 endingPage "e44916" @default.
• W2058149739 startingPage "e44916" @default.
• W2058149739 abstract "Lysosome-associated protein transmembrane 4 beta (LAPTM4B) has two alleles named LAPTM4B*1 and LAPTM4B*2. Allele *1 contains only one copy of a 19-bp sequence at the 5'UTR in the first exon, whereas this sequence of allele*2 is duplicated and arrayed as a tandem repeat. Previous studies revealed that LAPTM4B polymorphisms contribute to the risk of certain types of cancers. This study aimed to investigate the polymorphism of LAPTM4B in breast cancer by analysis the correlation of LAPTM4B genotype with breast cancer susceptibility, clinicopathologic features and prognosis.Genotyping of the LAPTM4B polymorphism was determined by PCR method. The expression levels of LAPTM4B in breast cancer tissues and breast cancer cell lines were determined by quantitative reverse-transcription PCR (qRT-PCR) analysis. The correlation of LAPTM4B genotype with clinicopathologic parameters and prognosis were assessed statistically.The results of qRT-PCR analysis indicated that LAPTM4B*2 was associated with the higher level of LAPTM4B expression compared with the LAPTM4B*1 in both breast cancer cell lines and breast cancer tissues. We found that LAPTM4B*2 was associated with an increased risk for breast cancer. LAPTM4B*2 was significantly associated with higher histopathologic grade, lymph node metastasis and poor prognosis.LAPTM4B*2 is a risk factor associated with breast cancer susceptibility and poor prognosis. LAPTM4B*2 may be a potential predicative marker for the susceptibility, progression and metastasis of breast cancer." @default.
• W2058149739 created "2016-06-24" @default.
• W2058149739 creator A5002930471 @default.
• W2058149739 creator A5008171524 @default.
• W2058149739 creator A5016935464 @default.
• W2058149739 creator A5036936468 @default.
• W2058149739 creator A5060489720 @default.
• W2058149739 creator A5076517655 @default.
• W2058149739 creator A5089079624 @default.
• W2058149739 date "2012-09-12" @default.
• W2058149739 modified "2023-09-25" @default.
• W2058149739 title "LAPTM4B Allele *2 Is Associated with Breast Cancer Susceptibility and Prognosis" @default.
• W2058149739 cites W1554348950 @default.
• W2058149739 cites W1966611821 @default.
• W2058149739 cites W1982406716 @default.
• W2058149739 cites W1982848581 @default.
• W2058149739 cites W1993362565 @default.
• W2058149739 cites W1994778124 @default.
• W2058149739 cites W1999543808 @default.
• W2058149739 cites W2002156016 @default.
• W2058149739 cites W2016655217 @default.
• W2058149739 cites W2034269086 @default.
• W2058149739 cites W2035396256 @default.
• W2058149739 cites W2042621065 @default.
• W2058149739 cites W2046334039 @default.
• W2058149739 cites W2061230387 @default.
• W2058149739 cites W2066749215 @default.
• W2058149739 cites W2083697259 @default.
• W2058149739 cites W2086254037 @default.
• W2058149739 cites W2088164239 @default.
• W2058149739 cites W2098222784 @default.
• W2058149739 cites W2117733417 @default.
• W2058149739 cites W2120491838 @default.
• W2058149739 cites W2121315081 @default.
• W2058149739 cites W2133891679 @default.
• W2058149739 cites W2146150410 @default.
• W2058149739 cites W2161686327 @default.
• W2058149739 cites W2165948908 @default.
• W2058149739 cites W2315840207 @default.
• W2058149739 cites W2322614604 @default.
• W2058149739 cites W2412556351 @default.
• W2058149739 doi "https://doi.org/10.1371/journal.pone.0044916" @default.
• W2058149739 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3440355" @default.
• W2058149739 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22984585" @default.
• W2058149739 hasPublicationYear "2012" @default.
• W2058149739 type Work @default.
• W2058149739 sameAs 2058149739 @default.
• W2058149739 citedByCount "25" @default.
• W2058149739 countsByYear W20581497392013 @default.
• W2058149739 countsByYear W20581497392014 @default.
• W2058149739 countsByYear W20581497392015 @default.
• W2058149739 countsByYear W20581497392016 @default.
• W2058149739 countsByYear W20581497392017 @default.
• W2058149739 countsByYear W20581497392018 @default.
• W2058149739 countsByYear W20581497392020 @default.
• W2058149739 crossrefType "journal-article" @default.
• W2058149739 hasAuthorship W2058149739A5002930471 @default.
• W2058149739 hasAuthorship W2058149739A5008171524 @default.
• W2058149739 hasAuthorship W2058149739A5016935464 @default.
• W2058149739 hasAuthorship W2058149739A5036936468 @default.
• W2058149739 hasAuthorship W2058149739A5060489720 @default.
• W2058149739 hasAuthorship W2058149739A5076517655 @default.
• W2058149739 hasAuthorship W2058149739A5089079624 @default.
• W2058149739 hasBestOaLocation W20581497391 @default.
• W2058149739 hasConcept C104317684 @default.
• W2058149739 hasConcept C121608353 @default.
• W2058149739 hasConcept C126322002 @default.
• W2058149739 hasConcept C135763542 @default.
• W2058149739 hasConcept C143998085 @default.
• W2058149739 hasConcept C180754005 @default.
• W2058149739 hasConcept C2779013556 @default.
• W2058149739 hasConcept C31467283 @default.
• W2058149739 hasConcept C502942594 @default.
• W2058149739 hasConcept C530470458 @default.
• W2058149739 hasConcept C54355233 @default.
• W2058149739 hasConcept C71924100 @default.
• W2058149739 hasConcept C86803240 @default.
• W2058149739 hasConceptScore W2058149739C104317684 @default.
• W2058149739 hasConceptScore W2058149739C121608353 @default.
• W2058149739 hasConceptScore W2058149739C126322002 @default.
• W2058149739 hasConceptScore W2058149739C135763542 @default.
• W2058149739 hasConceptScore W2058149739C143998085 @default.
• W2058149739 hasConceptScore W2058149739C180754005 @default.
• W2058149739 hasConceptScore W2058149739C2779013556 @default.
• W2058149739 hasConceptScore W2058149739C31467283 @default.
• W2058149739 hasConceptScore W2058149739C502942594 @default.
• W2058149739 hasConceptScore W2058149739C530470458 @default.
• W2058149739 hasConceptScore W2058149739C54355233 @default.
• W2058149739 hasConceptScore W2058149739C71924100 @default.
• W2058149739 hasConceptScore W2058149739C86803240 @default.
• W2058149739 hasIssue "9" @default.
• W2058149739 hasLocation W20581497391 @default.
• W2058149739 hasLocation W20581497392 @default.
• W2058149739 hasLocation W20581497393 @default.
• W2058149739 hasLocation W20581497394 @default.
• W2058149739 hasOpenAccess W2058149739 @default.
• W2058149739 hasPrimaryLocation W20581497391 @default.
• W2058149739 hasRelatedWork W121700474 @default.

• next