FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058156037> ?p ?o ?g. }

• W2058156037 endingPage "220" @default.
• W2058156037 startingPage "207" @default.
• W2058156037 abstract "Tissue damage by ischemia/reperfusion (I/R) results from a temporary cessation of blood flow followed by the restoration of circulation. The injury depresses mitochondrial respiration, increases the production of reactive oxygen species (ROS), decreases the mitochondrial transmembrane potential, and stimulates invasion by inflammatory cells. The primary objective of this work was to address the potential use of bone marrow stem cells (BMSCs) to preserve and restore mitochondrial function in the kidney after I/R. Mitochondria from renal proximal tubule cells were isolated by differential centrifugation from rat kidneys subjected to I/R (clamping of renal arteries followed by release of circulation after 30 min), without or with subcapsular administration of BMSCs. Respiration starting from mitochondrial complex II was strongly affected following I/R. However, when BMSCs were injected before ischemia or together with reperfusion, normal electron fluxes, electrochemical gradient for protons, and ATP synthesis were almost completely preserved, and mitochondrial ROS formation occurred at a low rate. In homogenates from cultured renal cells transiently treated with antimycin A, the coculture with BMSCs induced a remarkable increase in protein S-nitrosylation that was similar to that found in mitochondria isolated from I/R rats, evidence that BMSCs protected against both superoxide anion and peroxynitrite. Labeled BMSCs migrated to damaged tubules, suggesting that the injury functions as a signal to attract and host the injected BMSCs. Structural correlates of BMSC injection in kidney tissue included stimulus of tubule cell proliferation, inhibition of apoptosis, and decreased inflammatory response. Histopathological analysis demonstrated a score of complete preservation of tubular structures by BMSCs, associated with normal plasma creatinine and urinary osmolality. These key findings shed light on the mechanisms that explain, at the mitochondrial level, how stem cells prevent damage by I/R. The action of BMSCs on mitochondrial functions raises the possibility that autologous BMSCs may help prevent I/R injuries associated with transplantation and acute renal diseases." @default.
• W2058156037 created "2016-06-24" @default.
• W2058156037 creator A5019430575 @default.
• W2058156037 creator A5031987749 @default.
• W2058156037 creator A5036066960 @default.
• W2058156037 creator A5036302001 @default.
• W2058156037 creator A5040593914 @default.
• W2058156037 creator A5056941154 @default.
• W2058156037 creator A5058155757 @default.
• W2058156037 creator A5068764592 @default.
• W2058156037 creator A5088067381 @default.
• W2058156037 creator A5090142822 @default.
• W2058156037 date "2014-03-01" @default.
• W2058156037 modified "2023-09-30" @default.
• W2058156037 title "The Impact of Stem Cells on Electron Fluxes, Proton Translocation, and ATP Synthesis in Kidney Mitochondria after Ischemia/Reperfusion" @default.
• W2058156037 cites W1964437006 @default.
• W2058156037 cites W1966321632 @default.
• W2058156037 cites W1980267283 @default.
• W2058156037 cites W1981845473 @default.
• W2058156037 cites W1984974003 @default.
• W2058156037 cites W1992011928 @default.
• W2058156037 cites W1995613842 @default.
• W2058156037 cites W1998696969 @default.
• W2058156037 cites W1999457693 @default.
• W2058156037 cites W2004724154 @default.
• W2058156037 cites W2007530976 @default.
• W2058156037 cites W2007799395 @default.
• W2058156037 cites W2015424171 @default.
• W2058156037 cites W2016518118 @default.
• W2058156037 cites W2016693012 @default.
• W2058156037 cites W2018076136 @default.
• W2058156037 cites W2030079903 @default.
• W2058156037 cites W2033158597 @default.
• W2058156037 cites W2036127346 @default.
• W2058156037 cites W2036408541 @default.
• W2058156037 cites W2037159578 @default.
• W2058156037 cites W2037612957 @default.
• W2058156037 cites W2044636253 @default.
• W2058156037 cites W2061607183 @default.
• W2058156037 cites W2062336638 @default.
• W2058156037 cites W2071416216 @default.
• W2058156037 cites W2072176858 @default.
• W2058156037 cites W2074573663 @default.
• W2058156037 cites W2079100436 @default.
• W2058156037 cites W2100648382 @default.
• W2058156037 cites W2106475826 @default.
• W2058156037 cites W2108131089 @default.
• W2058156037 cites W2125238393 @default.
• W2058156037 cites W2126788226 @default.
• W2058156037 cites W2131317793 @default.
• W2058156037 cites W2145736817 @default.
• W2058156037 cites W2150914369 @default.
• W2058156037 cites W2155891625 @default.
• W2058156037 cites W2156179417 @default.
• W2058156037 cites W2166788705 @default.
• W2058156037 cites W2336335783 @default.
• W2058156037 cites W2342792498 @default.
• W2058156037 doi "https://doi.org/10.3727/096368912x659862" @default.
• W2058156037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23211430" @default.
• W2058156037 hasPublicationYear "2014" @default.
• W2058156037 type Work @default.
• W2058156037 sameAs 2058156037 @default.
• W2058156037 citedByCount "21" @default.
• W2058156037 countsByYear W20581560372014 @default.
• W2058156037 countsByYear W20581560372015 @default.
• W2058156037 countsByYear W20581560372018 @default.
• W2058156037 countsByYear W20581560372019 @default.
• W2058156037 countsByYear W20581560372020 @default.
• W2058156037 countsByYear W20581560372021 @default.
• W2058156037 countsByYear W20581560372022 @default.
• W2058156037 countsByYear W20581560372023 @default.
• W2058156037 crossrefType "journal-article" @default.
• W2058156037 hasAuthorship W2058156037A5019430575 @default.
• W2058156037 hasAuthorship W2058156037A5031987749 @default.
• W2058156037 hasAuthorship W2058156037A5036066960 @default.
• W2058156037 hasAuthorship W2058156037A5036302001 @default.
• W2058156037 hasAuthorship W2058156037A5040593914 @default.
• W2058156037 hasAuthorship W2058156037A5056941154 @default.
• W2058156037 hasAuthorship W2058156037A5058155757 @default.
• W2058156037 hasAuthorship W2058156037A5068764592 @default.
• W2058156037 hasAuthorship W2058156037A5088067381 @default.
• W2058156037 hasAuthorship W2058156037A5090142822 @default.
• W2058156037 hasConcept C126322002 @default.
• W2058156037 hasConcept C134018914 @default.
• W2058156037 hasConcept C181911157 @default.
• W2058156037 hasConcept C185592680 @default.
• W2058156037 hasConcept C2780091579 @default.
• W2058156037 hasConcept C28859421 @default.
• W2058156037 hasConcept C48349386 @default.
• W2058156037 hasConcept C541997718 @default.
• W2058156037 hasConcept C55493867 @default.
• W2058156037 hasConcept C71924100 @default.
• W2058156037 hasConcept C86803240 @default.
• W2058156037 hasConcept C95444343 @default.
• W2058156037 hasConceptScore W2058156037C126322002 @default.
• W2058156037 hasConceptScore W2058156037C134018914 @default.
• W2058156037 hasConceptScore W2058156037C181911157 @default.
• W2058156037 hasConceptScore W2058156037C185592680 @default.

• next