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• W2058163085 abstract "SUMMARY The circulating T cell pool of an MHC class II-deficient patient was shown to lack the MHC class II-specific T cell functions. This was demonstrated by the absence of MHC class Il-specific alloreactive T cells and a substantially decreased number of circulating CD4+ lymphocytes. The patient's T cells did respond to an allostimulus, although the restriction pattern of this reaction remains speculative. The function and distribution of peripheral T cell subsets from the patient resemble findings in MHC class II-deficient mice, which also lack interaction of T cell precursors with MHC class Il-bearing accessory cells during thymic differentiation. Our data support the concept that Tcell differentiation in humans is similar, and that the human MHC-restricted Tcell repertoire depends on prior interaction of T cell precursors with self MHC." @default.
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• W2058163085 date "1994-09-01" @default.
• W2058163085 modified "2023-10-17" @default.
• W2058163085 title "T cell differentiation and generation of the antigen-specific T cell repertoire in man: observations in MHC class II deficiency" @default.
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• W2058163085 doi "https://doi.org/10.1111/j.1365-2249.1994.tb06100.x" @default.
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