Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058163945> ?p ?o ?g. }
- W2058163945 endingPage "1704" @default.
- W2058163945 startingPage "1698" @default.
- W2058163945 abstract "BackgroundNearly 40% of patients with long QT syndrome (LQTS) can have a nondiagnostic QTc at rest. Treadmill and cycle exercise stress testing are used in the diagnostic evaluation of LQTS.ObjectiveThe purpose of this study was to determine the diagnostic significance of peak exercise and recovery phase QTc values during treadmill stress testing in LQTS.MethodsAn Institutional Review Board–approved, retrospective analysis was performed on the treadmill stress tests in 243 patients including 82 LQT1, 55 LQT2, 18 LQT3, and 88 genotype-negative patients dismissed as normal. Blinded to genotype, QTc was calculated at rest, peak exercise, and 1, 2, 3, 4, and 5 minutes of recovery.ResultsCompared with those dismissed as normal, the average QTc was greater at all scored stages in LQT1 and LQT3 patients and at all stages in LQT2 patients except peak exercise and 1 minute of recovery (P <.01). Either an absolute QTc ≥460 ms during the recovery phase or a maladaptive, paradoxical increase in QTc, defined as QTc recovery − QTc baseline ≥ 30 ms (ΔQTc), distinguished patients with either manifest or concealed LQT1 from all other subsets (P <.0001). The presence of beta-blockers did not blunt these abnormal repolarization profiles.ConclusionTreadmill stress testing can unmask patients with concealed LQTS, particularly LQT1, with good diagnostic accuracy. Nearly 40% of patients with long QT syndrome (LQTS) can have a nondiagnostic QTc at rest. Treadmill and cycle exercise stress testing are used in the diagnostic evaluation of LQTS. The purpose of this study was to determine the diagnostic significance of peak exercise and recovery phase QTc values during treadmill stress testing in LQTS. An Institutional Review Board–approved, retrospective analysis was performed on the treadmill stress tests in 243 patients including 82 LQT1, 55 LQT2, 18 LQT3, and 88 genotype-negative patients dismissed as normal. Blinded to genotype, QTc was calculated at rest, peak exercise, and 1, 2, 3, 4, and 5 minutes of recovery. Compared with those dismissed as normal, the average QTc was greater at all scored stages in LQT1 and LQT3 patients and at all stages in LQT2 patients except peak exercise and 1 minute of recovery (P <.01). Either an absolute QTc ≥460 ms during the recovery phase or a maladaptive, paradoxical increase in QTc, defined as QTc recovery − QTc baseline ≥ 30 ms (ΔQTc), distinguished patients with either manifest or concealed LQT1 from all other subsets (P <.0001). The presence of beta-blockers did not blunt these abnormal repolarization profiles. Treadmill stress testing can unmask patients with concealed LQTS, particularly LQT1, with good diagnostic accuracy." @default.
- W2058163945 created "2016-06-24" @default.
- W2058163945 creator A5001172000 @default.
- W2058163945 creator A5055125250 @default.
- W2058163945 creator A5069997790 @default.
- W2058163945 date "2011-11-01" @default.
- W2058163945 modified "2023-10-18" @default.
- W2058163945 title "The diagnostic utility of recovery phase QTc during treadmill exercise stress testing in the evaluation of long QT syndrome" @default.
- W2058163945 cites W184895251 @default.
- W2058163945 cites W1968683118 @default.
- W2058163945 cites W1969936538 @default.
- W2058163945 cites W1982595389 @default.
- W2058163945 cites W1994873020 @default.
- W2058163945 cites W2026645081 @default.
- W2058163945 cites W2029928625 @default.
- W2058163945 cites W2036225695 @default.
- W2058163945 cites W2063918785 @default.
- W2058163945 cites W2077501844 @default.
- W2058163945 cites W2084756418 @default.
- W2058163945 cites W2094662185 @default.
- W2058163945 cites W2103096104 @default.
- W2058163945 cites W2116371588 @default.
- W2058163945 cites W2124865340 @default.
- W2058163945 cites W2145378539 @default.
- W2058163945 cites W2150535358 @default.
- W2058163945 cites W2151361417 @default.
- W2058163945 cites W2156072530 @default.
- W2058163945 cites W2164694166 @default.
- W2058163945 doi "https://doi.org/10.1016/j.hrthm.2011.05.018" @default.
- W2058163945 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21699858" @default.
- W2058163945 hasPublicationYear "2011" @default.
- W2058163945 type Work @default.
- W2058163945 sameAs 2058163945 @default.
- W2058163945 citedByCount "119" @default.
- W2058163945 countsByYear W20581639452012 @default.
- W2058163945 countsByYear W20581639452013 @default.
- W2058163945 countsByYear W20581639452014 @default.
- W2058163945 countsByYear W20581639452015 @default.
- W2058163945 countsByYear W20581639452016 @default.
- W2058163945 countsByYear W20581639452017 @default.
- W2058163945 countsByYear W20581639452018 @default.
- W2058163945 countsByYear W20581639452019 @default.
- W2058163945 countsByYear W20581639452020 @default.
- W2058163945 countsByYear W20581639452021 @default.
- W2058163945 countsByYear W20581639452022 @default.
- W2058163945 countsByYear W20581639452023 @default.
- W2058163945 crossrefType "journal-article" @default.
- W2058163945 hasAuthorship W2058163945A5001172000 @default.
- W2058163945 hasAuthorship W2058163945A5055125250 @default.
- W2058163945 hasAuthorship W2058163945A5069997790 @default.
- W2058163945 hasConcept C118441451 @default.
- W2058163945 hasConcept C126322002 @default.
- W2058163945 hasConcept C130049864 @default.
- W2058163945 hasConcept C146403970 @default.
- W2058163945 hasConcept C164705383 @default.
- W2058163945 hasConcept C185263204 @default.
- W2058163945 hasConcept C199360897 @default.
- W2058163945 hasConcept C2777953023 @default.
- W2058163945 hasConcept C2779703243 @default.
- W2058163945 hasConcept C2780040984 @default.
- W2058163945 hasConcept C2781464450 @default.
- W2058163945 hasConcept C41008148 @default.
- W2058163945 hasConcept C42219234 @default.
- W2058163945 hasConcept C71924100 @default.
- W2058163945 hasConcept C7515471 @default.
- W2058163945 hasConcept C84393581 @default.
- W2058163945 hasConceptScore W2058163945C118441451 @default.
- W2058163945 hasConceptScore W2058163945C126322002 @default.
- W2058163945 hasConceptScore W2058163945C130049864 @default.
- W2058163945 hasConceptScore W2058163945C146403970 @default.
- W2058163945 hasConceptScore W2058163945C164705383 @default.
- W2058163945 hasConceptScore W2058163945C185263204 @default.
- W2058163945 hasConceptScore W2058163945C199360897 @default.
- W2058163945 hasConceptScore W2058163945C2777953023 @default.
- W2058163945 hasConceptScore W2058163945C2779703243 @default.
- W2058163945 hasConceptScore W2058163945C2780040984 @default.
- W2058163945 hasConceptScore W2058163945C2781464450 @default.
- W2058163945 hasConceptScore W2058163945C41008148 @default.
- W2058163945 hasConceptScore W2058163945C42219234 @default.
- W2058163945 hasConceptScore W2058163945C71924100 @default.
- W2058163945 hasConceptScore W2058163945C7515471 @default.
- W2058163945 hasConceptScore W2058163945C84393581 @default.
- W2058163945 hasIssue "11" @default.
- W2058163945 hasLocation W20581639451 @default.
- W2058163945 hasLocation W20581639452 @default.
- W2058163945 hasOpenAccess W2058163945 @default.
- W2058163945 hasPrimaryLocation W20581639451 @default.
- W2058163945 hasRelatedWork W2033888008 @default.
- W2058163945 hasRelatedWork W2058163945 @default.
- W2058163945 hasRelatedWork W2062288119 @default.
- W2058163945 hasRelatedWork W2092950144 @default.
- W2058163945 hasRelatedWork W2133442649 @default.
- W2058163945 hasRelatedWork W2526452705 @default.
- W2058163945 hasRelatedWork W2601895312 @default.
- W2058163945 hasRelatedWork W3106754853 @default.
- W2058163945 hasRelatedWork W4237478000 @default.
- W2058163945 hasRelatedWork W4255707928 @default.
- W2058163945 hasVolume "8" @default.