FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058164920> ?p ?o ?g. }

• W2058164920 endingPage "452" @default.
• W2058164920 startingPage "443" @default.
• W2058164920 abstract "Abstract Abnormalities of hemoglobin synthesis are usually inherited but may also arise as a secondary manifestation of another disease, most commonly hematologic neoplasia. Acquired hemoglobin disorders can be seen in any population and are not restricted to areas of the world with high incidences of inherited hemoglobinopathies. In fact, the acquired hemoglobinopathies may be more readily recognized where inherited hemoglobin abnormalities are rare and less likely to cause diagnostic confusion. Acquired α-thalassemia is the best characterized of the acquired red blood cell disorders in patients with hematologic malignancy, and it is almost always associated with a myelodysplastic syndrome (MDS). At least 2 molecular mechanisms for acquired α-thalassemia are now recognized: acquired deletion of the α-globin gene cluster limited to the neoplastic clone and, more commonly, inactivating somatic mutations of the trans-acting chromatin-associated factor ATRX, which cause dramatic down-regulation of α-globin gene expression. Here we review the clinical, hematologic, and molecular genetic features of α-thalassemia arising in a clonal myeloid disorder, and we discuss howATRX might affect gene expression in normal and abnormal hematopoiesis through epigenetic mechanisms." @default.
• W2058164920 created "2016-06-24" @default.
• W2058164920 creator A5014949168 @default.
• W2058164920 creator A5060337902 @default.
• W2058164920 creator A5077104483 @default.
• W2058164920 date "2005-01-15" @default.
• W2058164920 modified "2023-10-07" @default.
• W2058164920 title "Acquired α-thalassemia in association with myelodysplastic syndrome and other hematologic malignancies" @default.
• W2058164920 cites W1277787372 @default.
• W2058164920 cites W1523189772 @default.
• W2058164920 cites W1556421650 @default.
• W2058164920 cites W1603793127 @default.
• W2058164920 cites W170079721 @default.
• W2058164920 cites W1838266191 @default.
• W2058164920 cites W187238933 @default.
• W2058164920 cites W1968066423 @default.
• W2058164920 cites W1971411877 @default.
• W2058164920 cites W1974217358 @default.
• W2058164920 cites W1988105023 @default.
• W2058164920 cites W1996092443 @default.
• W2058164920 cites W1997832945 @default.
• W2058164920 cites W1998602132 @default.
• W2058164920 cites W2004172747 @default.
• W2058164920 cites W2006455644 @default.
• W2058164920 cites W2012224269 @default.
• W2058164920 cites W2019904951 @default.
• W2058164920 cites W2029549314 @default.
• W2058164920 cites W2031931343 @default.
• W2058164920 cites W2032540463 @default.
• W2058164920 cites W2033909498 @default.
• W2058164920 cites W2036584876 @default.
• W2058164920 cites W2040257851 @default.
• W2058164920 cites W2046264209 @default.
• W2058164920 cites W2047187117 @default.
• W2058164920 cites W2056233124 @default.
• W2058164920 cites W2058004626 @default.
• W2058164920 cites W2060097324 @default.
• W2058164920 cites W2061022183 @default.
• W2058164920 cites W2062918665 @default.
• W2058164920 cites W2065109174 @default.
• W2058164920 cites W2067964865 @default.
• W2058164920 cites W2070275649 @default.
• W2058164920 cites W2070574925 @default.
• W2058164920 cites W2071000969 @default.
• W2058164920 cites W2071966631 @default.
• W2058164920 cites W2079703454 @default.
• W2058164920 cites W2081442014 @default.
• W2058164920 cites W2084169030 @default.
• W2058164920 cites W2086556990 @default.
• W2058164920 cites W2094376975 @default.
• W2058164920 cites W2096242643 @default.
• W2058164920 cites W2101092089 @default.
• W2058164920 cites W2101871282 @default.
• W2058164920 cites W2103183093 @default.
• W2058164920 cites W2105077997 @default.
• W2058164920 cites W2112578189 @default.
• W2058164920 cites W2115911937 @default.
• W2058164920 cites W2116862022 @default.
• W2058164920 cites W2125600565 @default.
• W2058164920 cites W2128995137 @default.
• W2058164920 cites W2139317259 @default.
• W2058164920 cites W2140705509 @default.
• W2058164920 cites W2141340108 @default.
• W2058164920 cites W2153823300 @default.
• W2058164920 cites W2210620858 @default.
• W2058164920 cites W2319226114 @default.
• W2058164920 cites W2323036506 @default.
• W2058164920 cites W2354344320 @default.
• W2058164920 cites W2436917741 @default.
• W2058164920 cites W4240127361 @default.
• W2058164920 cites W4253916874 @default.
• W2058164920 cites W4302354217 @default.
• W2058164920 cites W78648644 @default.
• W2058164920 doi "https://doi.org/10.1182/blood-2004-07-2792" @default.
• W2058164920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15358626" @default.
• W2058164920 hasPublicationYear "2005" @default.
• W2058164920 type Work @default.
• W2058164920 sameAs 2058164920 @default.
• W2058164920 citedByCount "98" @default.
• W2058164920 countsByYear W20581649202012 @default.
• W2058164920 countsByYear W20581649202013 @default.
• W2058164920 countsByYear W20581649202014 @default.
• W2058164920 countsByYear W20581649202015 @default.
• W2058164920 countsByYear W20581649202016 @default.
• W2058164920 countsByYear W20581649202017 @default.
• W2058164920 countsByYear W20581649202018 @default.
• W2058164920 countsByYear W20581649202019 @default.
• W2058164920 countsByYear W20581649202020 @default.
• W2058164920 countsByYear W20581649202021 @default.
• W2058164920 countsByYear W20581649202022 @default.
• W2058164920 countsByYear W20581649202023 @default.
• W2058164920 crossrefType "journal-article" @default.
• W2058164920 hasAuthorship W2058164920A5014949168 @default.
• W2058164920 hasAuthorship W2058164920A5060337902 @default.
• W2058164920 hasAuthorship W2058164920A5077104483 @default.
• W2058164920 hasBestOaLocation W20581649201 @default.
• W2058164920 hasConcept C142724271 @default.
• W2058164920 hasConcept C203014093 @default.

• next