Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058193765> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2058193765 endingPage "240A" @default.
- W2058193765 startingPage "240A" @default.
- W2058193765 abstract "Previously, using immunocytochemistry for the proliferating cell nuclear antigen, we detected low levels of replication (≤ 1%) in 100 restenotic coronary atherectomy specimens. Histone H3 mRNA increases 30-50-fold as cells pass through S phase of the cell cycle and can be used as an independent marker of cell replication. Therefore, using in situ hybridization for histone H3 mRNA we examined the proliferative profile of: i) coronary atherectomy specimens (n = 12) obtained within the first 60 days after a previous interventional procedure, and ii) primary (n = 13) and restenotic (n = 10) peripheral atherectomy specimens because of their larger tissue sample size. For these respective tissue groups, the number of specimens that had any cells expressing histone mRNA on a slide were 2/12, 5/13 and 7/10. The total number of cells per slide expressing histone H3 mRNA ranged from 0 to 23.0 to 82 and 0 to 118 for these 3 groups of specimens. Typical coronary and peripheral atherectomy specimens contain 4,500 and 10,200 cells per slide, respectively. Therefore, the highest replication profiles (0.5%, 1.2%) were seen in restenotic coronary and peripheral artery specimens obtained 1 and 2 days post-atherectomy, respectively. Smooth muscle and endothelial cells expressed histone H3 mRNA. These results suggest that: 1) replication is a modest event in human atherosclerosis and restenosis; 2) replication may be more prevalent in peripheral compared to coronary atherectomy specimens; and 3) anecdotally, an important time window for proliferation may be in the days immediately post-intervention." @default.
- W2058193765 created "2016-06-24" @default.
- W2058193765 creator A5005605475 @default.
- W2058193765 creator A5006236717 @default.
- W2058193765 creator A5011813232 @default.
- W2058193765 creator A5011815355 @default.
- W2058193765 creator A5021017639 @default.
- W2058193765 creator A5038517609 @default.
- W2058193765 creator A5043857610 @default.
- W2058193765 creator A5048645249 @default.
- W2058193765 date "1995-02-01" @default.
- W2058193765 modified "2023-10-16" @default.
- W2058193765 title "968-23 Evaluation of Proliferation in Human Atherectomy Specimens Using In Situ Hybridization for Histone H3" @default.
- W2058193765 doi "https://doi.org/10.1016/0735-1097(95)92457-g" @default.
- W2058193765 hasPublicationYear "1995" @default.
- W2058193765 type Work @default.
- W2058193765 sameAs 2058193765 @default.
- W2058193765 citedByCount "3" @default.
- W2058193765 crossrefType "journal-article" @default.
- W2058193765 hasAuthorship W2058193765A5005605475 @default.
- W2058193765 hasAuthorship W2058193765A5006236717 @default.
- W2058193765 hasAuthorship W2058193765A5011813232 @default.
- W2058193765 hasAuthorship W2058193765A5011815355 @default.
- W2058193765 hasAuthorship W2058193765A5021017639 @default.
- W2058193765 hasAuthorship W2058193765A5038517609 @default.
- W2058193765 hasAuthorship W2058193765A5043857610 @default.
- W2058193765 hasAuthorship W2058193765A5048645249 @default.
- W2058193765 hasBestOaLocation W20581937651 @default.
- W2058193765 hasConcept C104317684 @default.
- W2058193765 hasConcept C105580179 @default.
- W2058193765 hasConcept C126322002 @default.
- W2058193765 hasConcept C142724271 @default.
- W2058193765 hasConcept C153911025 @default.
- W2058193765 hasConcept C2776745794 @default.
- W2058193765 hasConcept C2776820930 @default.
- W2058193765 hasConcept C2777209855 @default.
- W2058193765 hasConcept C2778283817 @default.
- W2058193765 hasConcept C2778583881 @default.
- W2058193765 hasConcept C55493867 @default.
- W2058193765 hasConcept C64927066 @default.
- W2058193765 hasConcept C71924100 @default.
- W2058193765 hasConcept C81439078 @default.
- W2058193765 hasConcept C86803240 @default.
- W2058193765 hasConceptScore W2058193765C104317684 @default.
- W2058193765 hasConceptScore W2058193765C105580179 @default.
- W2058193765 hasConceptScore W2058193765C126322002 @default.
- W2058193765 hasConceptScore W2058193765C142724271 @default.
- W2058193765 hasConceptScore W2058193765C153911025 @default.
- W2058193765 hasConceptScore W2058193765C2776745794 @default.
- W2058193765 hasConceptScore W2058193765C2776820930 @default.
- W2058193765 hasConceptScore W2058193765C2777209855 @default.
- W2058193765 hasConceptScore W2058193765C2778283817 @default.
- W2058193765 hasConceptScore W2058193765C2778583881 @default.
- W2058193765 hasConceptScore W2058193765C55493867 @default.
- W2058193765 hasConceptScore W2058193765C64927066 @default.
- W2058193765 hasConceptScore W2058193765C71924100 @default.
- W2058193765 hasConceptScore W2058193765C81439078 @default.
- W2058193765 hasConceptScore W2058193765C86803240 @default.
- W2058193765 hasIssue "2" @default.
- W2058193765 hasLocation W20581937651 @default.
- W2058193765 hasOpenAccess W2058193765 @default.
- W2058193765 hasPrimaryLocation W20581937651 @default.
- W2058193765 hasRelatedWork W2004121582 @default.
- W2058193765 hasRelatedWork W2030540411 @default.
- W2058193765 hasRelatedWork W2039581034 @default.
- W2058193765 hasRelatedWork W2058193765 @default.
- W2058193765 hasRelatedWork W2081084759 @default.
- W2058193765 hasRelatedWork W2087524031 @default.
- W2058193765 hasRelatedWork W2340654967 @default.
- W2058193765 hasRelatedWork W2393886125 @default.
- W2058193765 hasRelatedWork W2419360986 @default.
- W2058193765 hasRelatedWork W2047345177 @default.
- W2058193765 hasVolume "25" @default.
- W2058193765 isParatext "false" @default.
- W2058193765 isRetracted "false" @default.
- W2058193765 magId "2058193765" @default.
- W2058193765 workType "article" @default.