FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058195837> ?p ?o ?g. }

• W2058195837 endingPage "342" @default.
• W2058195837 startingPage "333" @default.
• W2058195837 abstract "We investigated the effects of dantrolene sodium on intracellular Ca2+ homeostasis in normal and Ca2+ overloaded rat cardiac muscle. In isometrically contracting rat papillary muscles loaded with the Ca2+ indicator aequorin, dantrolene (50 μM) produced a mild negative inotropic effect (28 ± 1.8 to 21 ± 1.1 mN/mm2; mean ± S.E.; n = 6; P < 0.01), which was paralleled by a decrease in peak systolic [Ca2+]i (0.81 ± 0.04 to 0.67 ± 0.04 μM; P < 0.01). In isolated cardiac sarcoplasmic reticulum, dantrolene (50 μM) increased the initial Ca2+ uptake rate by 23% as compared to control preparations (at pCa 6.2: 46.9 ± 1.6 to 61.1 ± 2.2 nmol/mg per min; n = 4; P < 0.001). Intracellular Ca2+ overload was provoked in isoproterenol-pretreated (100 μM) preparations with [Ca2+]o = 5.0 mM at a stimulation rate of 1.0 Hz (n = 12). Diastolic Ca2+ oscillations and aftercontractions increased mean diastolic [Ca2+]i (0.33 ± 0.1 to 0.56 ± 0.1 μM) and tension (9.5 ± 1.8 to 15.3 ± 2.1 mN/mm2), respectively. Addition of dantrolene (50 μM) reduced the amplitude of Ca2+ oscillations and aftercontractions; mean diastolic [Ca2+]i decreased to 0.44 ± 0.1 μM and diastolic tension to 13.5 ± 2.2 mN/mm2. We conclude, therefore, that dantrolene sodium modifies Ca2+ handling by the myocardial sarcoplasmic reticulum, an effect that might be useful in cardiac disorders with impaired [Ca2+]i homeostasis." @default.
• W2058195837 created "2016-06-24" @default.
• W2058195837 creator A5032757247 @default.
• W2058195837 creator A5082538911 @default.
• W2058195837 creator A5089576007 @default.
• W2058195837 date "1996-12-01" @default.
• W2058195837 modified "2023-09-24" @default.
• W2058195837 title "Effects of dantrolene sodium on intracellular Ca2+-handling in normal and Ca2+-overloaded cardiac muscle" @default.
• W2058195837 cites W1496600948 @default.
• W2058195837 cites W1572418927 @default.
• W2058195837 cites W1775749144 @default.
• W2058195837 cites W1967824319 @default.
• W2058195837 cites W1971734220 @default.
• W2058195837 cites W1975547534 @default.
• W2058195837 cites W1979134839 @default.
• W2058195837 cites W1985236300 @default.
• W2058195837 cites W1997714759 @default.
• W2058195837 cites W2008714169 @default.
• W2058195837 cites W2026319417 @default.
• W2058195837 cites W2033892695 @default.
• W2058195837 cites W2034747201 @default.
• W2058195837 cites W2039547987 @default.
• W2058195837 cites W2049858915 @default.
• W2058195837 cites W2058483193 @default.
• W2058195837 cites W2061610042 @default.
• W2058195837 cites W2075021708 @default.
• W2058195837 cites W2076043526 @default.
• W2058195837 cites W2076910520 @default.
• W2058195837 cites W2078232455 @default.
• W2058195837 cites W2078382084 @default.
• W2058195837 cites W2091867363 @default.
• W2058195837 cites W2107658071 @default.
• W2058195837 cites W2120337309 @default.
• W2058195837 cites W2127357709 @default.
• W2058195837 cites W2148866893 @default.
• W2058195837 cites W2149807266 @default.
• W2058195837 cites W2317777815 @default.
• W2058195837 cites W3146777902 @default.
• W2058195837 cites W4376849603 @default.
• W2058195837 doi "https://doi.org/10.1016/s0014-2999(96)00678-4" @default.
• W2058195837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8982705" @default.
• W2058195837 hasPublicationYear "1996" @default.
• W2058195837 type Work @default.
• W2058195837 sameAs 2058195837 @default.
• W2058195837 citedByCount "20" @default.
• W2058195837 countsByYear W20581958372013 @default.
• W2058195837 countsByYear W20581958372016 @default.
• W2058195837 countsByYear W20581958372017 @default.
• W2058195837 countsByYear W20581958372019 @default.
• W2058195837 countsByYear W20581958372021 @default.
• W2058195837 countsByYear W20581958372022 @default.
• W2058195837 crossrefType "journal-article" @default.
• W2058195837 hasAuthorship W2058195837A5032757247 @default.
• W2058195837 hasAuthorship W2058195837A5082538911 @default.
• W2058195837 hasAuthorship W2058195837A5089576007 @default.
• W2058195837 hasConcept C113217602 @default.
• W2058195837 hasConcept C126322002 @default.
• W2058195837 hasConcept C134018914 @default.
• W2058195837 hasConcept C155710745 @default.
• W2058195837 hasConcept C158617107 @default.
• W2058195837 hasConcept C178790620 @default.
• W2058195837 hasConcept C185592680 @default.
• W2058195837 hasConcept C2775953344 @default.
• W2058195837 hasConcept C2778996579 @default.
• W2058195837 hasConcept C2781460320 @default.
• W2058195837 hasConcept C2910132651 @default.
• W2058195837 hasConcept C519063684 @default.
• W2058195837 hasConcept C537181965 @default.
• W2058195837 hasConcept C55493867 @default.
• W2058195837 hasConcept C57900726 @default.
• W2058195837 hasConcept C63645605 @default.
• W2058195837 hasConcept C71924100 @default.
• W2058195837 hasConcept C79879829 @default.
• W2058195837 hasConcept C84393581 @default.
• W2058195837 hasConceptScore W2058195837C113217602 @default.
• W2058195837 hasConceptScore W2058195837C126322002 @default.
• W2058195837 hasConceptScore W2058195837C134018914 @default.
• W2058195837 hasConceptScore W2058195837C155710745 @default.
• W2058195837 hasConceptScore W2058195837C158617107 @default.
• W2058195837 hasConceptScore W2058195837C178790620 @default.
• W2058195837 hasConceptScore W2058195837C185592680 @default.
• W2058195837 hasConceptScore W2058195837C2775953344 @default.
• W2058195837 hasConceptScore W2058195837C2778996579 @default.
• W2058195837 hasConceptScore W2058195837C2781460320 @default.
• W2058195837 hasConceptScore W2058195837C2910132651 @default.
• W2058195837 hasConceptScore W2058195837C519063684 @default.
• W2058195837 hasConceptScore W2058195837C537181965 @default.
• W2058195837 hasConceptScore W2058195837C55493867 @default.
• W2058195837 hasConceptScore W2058195837C57900726 @default.
• W2058195837 hasConceptScore W2058195837C63645605 @default.
• W2058195837 hasConceptScore W2058195837C71924100 @default.
• W2058195837 hasConceptScore W2058195837C79879829 @default.
• W2058195837 hasConceptScore W2058195837C84393581 @default.
• W2058195837 hasIssue "2-3" @default.
• W2058195837 hasLocation W20581958371 @default.
• W2058195837 hasLocation W20581958372 @default.
• W2058195837 hasOpenAccess W2058195837 @default.
• W2058195837 hasPrimaryLocation W20581958371 @default.

• next