FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058211727> ?p ?o ?g. }

• W2058211727 endingPage "128" @default.
• W2058211727 startingPage "120" @default.
• W2058211727 abstract "Plasmid-loaded microspheres can provide localized and sustained release into the target tissue, and thus have the potential to enhance the efficiency of naked DNA at promoting transgene expression. In this report, microsphere design parameters are investigated by correlating the extent and duration of transgene expression intramuscularly to the polymer molecular weight and the mass of DNA delivered. Plasmid DNA was incorporated into poly (lactide-co-glycolide) microspheres using a cryogenic double emulsion process, and microspheres were injected intramuscularly. Bolus injection of naked plasmid was used for control, which exhibited transfection of muscle cells with transgene expression that gradually decreased over time. Microspheres fabricated from low molecular weight polymer had expression levels that increased from day 1 to day 92, which subsequently decreased through day 174. Decreasing the microsphere mass delivered resulted in steady expression during the same time. However, microspheres fabricated with high molecular weight polymer had expression for only 14 days. Intramuscular injection resulted in a foreign body response to the microspheres, and these infiltrating cells adjacent were primarily transfected. This understanding of microsphere properties that determine transgene expression and the distribution of transfected cells may facilitate their application to fields such as tissue engineering or DNA vaccines." @default.
• W2058211727 created "2016-06-24" @default.
• W2058211727 creator A5074607551 @default.
• W2058211727 creator A5083516725 @default.
• W2058211727 date "2006-05-01" @default.
• W2058211727 modified "2023-10-17" @default.
• W2058211727 title "Intramuscular delivery of DNA releasing microspheres: Microsphere properties and transgene expression" @default.
• W2058211727 cites W1520821663 @default.
• W2058211727 cites W1570488545 @default.
• W2058211727 cites W1964449683 @default.
• W2058211727 cites W1964749479 @default.
• W2058211727 cites W1965033562 @default.
• W2058211727 cites W1969918693 @default.
• W2058211727 cites W1971700667 @default.
• W2058211727 cites W1981856730 @default.
• W2058211727 cites W1983706639 @default.
• W2058211727 cites W1985100447 @default.
• W2058211727 cites W1987078974 @default.
• W2058211727 cites W1992847347 @default.
• W2058211727 cites W1995317461 @default.
• W2058211727 cites W1999375292 @default.
• W2058211727 cites W2001018507 @default.
• W2058211727 cites W2010848777 @default.
• W2058211727 cites W2013303339 @default.
• W2058211727 cites W2014495927 @default.
• W2058211727 cites W2018744718 @default.
• W2058211727 cites W2019565030 @default.
• W2058211727 cites W2026701957 @default.
• W2058211727 cites W2030867061 @default.
• W2058211727 cites W2031883585 @default.
• W2058211727 cites W2035648566 @default.
• W2058211727 cites W2035799053 @default.
• W2058211727 cites W2041414322 @default.
• W2058211727 cites W2047796161 @default.
• W2058211727 cites W2054953746 @default.
• W2058211727 cites W2055866192 @default.
• W2058211727 cites W2060270742 @default.
• W2058211727 cites W2063755160 @default.
• W2058211727 cites W2071103044 @default.
• W2058211727 cites W2071892520 @default.
• W2058211727 cites W2083896229 @default.
• W2058211727 cites W2086358894 @default.
• W2058211727 cites W2086656837 @default.
• W2058211727 cites W2091145552 @default.
• W2058211727 cites W2097738098 @default.
• W2058211727 cites W2114754387 @default.
• W2058211727 cites W2122018739 @default.
• W2058211727 cites W2157684229 @default.
• W2058211727 cites W2159169254 @default.
• W2058211727 cites W2164414888 @default.
• W2058211727 cites W2315165762 @default.
• W2058211727 cites W2331665565 @default.
• W2058211727 cites W79619366 @default.
• W2058211727 doi "https://doi.org/10.1016/j.jconrel.2006.01.013" @default.
• W2058211727 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2648407" @default.
• W2058211727 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16530876" @default.
• W2058211727 hasPublicationYear "2006" @default.
• W2058211727 type Work @default.
• W2058211727 sameAs 2058211727 @default.
• W2058211727 citedByCount "54" @default.
• W2058211727 countsByYear W20582117272012 @default.
• W2058211727 countsByYear W20582117272013 @default.
• W2058211727 countsByYear W20582117272014 @default.
• W2058211727 countsByYear W20582117272015 @default.
• W2058211727 countsByYear W20582117272016 @default.
• W2058211727 countsByYear W20582117272017 @default.
• W2058211727 countsByYear W20582117272018 @default.
• W2058211727 countsByYear W20582117272019 @default.
• W2058211727 countsByYear W20582117272021 @default.
• W2058211727 countsByYear W20582117272022 @default.
• W2058211727 countsByYear W20582117272023 @default.
• W2058211727 crossrefType "journal-article" @default.
• W2058211727 hasAuthorship W2058211727A5074607551 @default.
• W2058211727 hasAuthorship W2058211727A5083516725 @default.
• W2058211727 hasBestOaLocation W20582117272 @default.
• W2058211727 hasConcept C102230213 @default.
• W2058211727 hasConcept C104317684 @default.
• W2058211727 hasConcept C111599444 @default.
• W2058211727 hasConcept C12554922 @default.
• W2058211727 hasConcept C127413603 @default.
• W2058211727 hasConcept C135983454 @default.
• W2058211727 hasConcept C136229726 @default.
• W2058211727 hasConcept C153911025 @default.
• W2058211727 hasConcept C185592680 @default.
• W2058211727 hasConcept C189942447 @default.
• W2058211727 hasConcept C195856716 @default.
• W2058211727 hasConcept C22744801 @default.
• W2058211727 hasConcept C42360764 @default.
• W2058211727 hasConcept C54009773 @default.
• W2058211727 hasConcept C552990157 @default.
• W2058211727 hasConcept C55493867 @default.
• W2058211727 hasConcept C71924100 @default.
• W2058211727 hasConcept C86803240 @default.
• W2058211727 hasConceptScore W2058211727C102230213 @default.
• W2058211727 hasConceptScore W2058211727C104317684 @default.
• W2058211727 hasConceptScore W2058211727C111599444 @default.
• W2058211727 hasConceptScore W2058211727C12554922 @default.
• W2058211727 hasConceptScore W2058211727C127413603 @default.

• next