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• W2058218780 startingPage "6658" @default.
• W2058218780 abstract "Cancer cells are able to overproduce lactic acid aerobically, whereas normal cells undergo anaerobic glycolysis only when deprived of oxygen. Tumor aerobic glycolysis was recognized about seven decades ago; however, its molecular basis has remained elusive. The lactate dehydrogenase-A gene ( LDH-A ), whose product participates in normal anaerobic glycolysis and is frequently increased in human cancers, was identified as a c-Myc-responsive gene. Stably transfected Rat1a fibroblasts that overexpress LDH-A alone or those transformed by c-Myc overproduce lactic acid. LDH-A overexpression is required for c-Myc-mediated transformation because lowering its level through antisense LDH-A expression reduces soft agar clonogenicity of c-Myc-transformed Rat1a fibroblasts, c-Myc-transformed human lymphoblastoid cells, and Burkitt lymphoma cells. Although antisense expression of LDH-A did not affect the growth of c-Myc-transformed fibroblasts adherent to culture dishes under normoxic conditions, the growth of these adherent cells in hypoxia was reduced. These observations suggest that an increased LDH-A level is required for the growth of a transformed spheroid cell mass, which has a hypoxic internal microenvironment. Our studies have linked c-Myc to the induction of LDH-A , whose expression increases lactate production and is necessary for c-Myc-mediated transformation." @default.
• W2058218780 created "2016-06-24" @default.
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• W2058218780 date "1997-06-24" @default.
• W2058218780 modified "2023-10-05" @default.
• W2058218780 title "c-Myc transactivation of <i>LDH-A</i> : Implications for tumor metabolism and growth" @default.
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• W2058218780 doi "https://doi.org/10.1073/pnas.94.13.6658" @default.
• W2058218780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/21214" @default.
• W2058218780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9192621" @default.
• W2058218780 hasPublicationYear "1997" @default.
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