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- W2058223290 endingPage "799" @default.
- W2058223290 startingPage "791" @default.
- W2058223290 abstract "DNA double-strand breaks (DSBs) are highly hazardous for genome integrity because they have the potential to cause mutations, chromosomal rearrangements and genomic instability. The cellular response to DSBs is orchestrated by signal transduction pathways, known as DNA damage checkpoints, which are conserved from yeasts to humans. These pathways can sense DNA damage and transduce this information to specific cellular targets, which in turn regulate cell cycle transitions and DNA repair. The mammalian protein kinases ATM and ATR, as well as their budding yeast corresponding orthologs Tel1 and Mec1, act as master regulators of the checkpoint response to DSBs. Here, we review the early steps of DSB processing and the role of DNA-end structures in activating ATM/Tel1 and ATR/Mec1 in an orderly and reciprocal manner." @default.
- W2058223290 created "2016-06-24" @default.
- W2058223290 creator A5019729249 @default.
- W2058223290 creator A5053604101 @default.
- W2058223290 creator A5063731209 @default.
- W2058223290 creator A5068251997 @default.
- W2058223290 creator A5077831719 @default.
- W2058223290 date "2013-10-01" @default.
- W2058223290 modified "2023-10-16" @default.
- W2058223290 title "Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks" @default.
- W2058223290 cites W1492634884 @default.
- W2058223290 cites W1592309404 @default.
- W2058223290 cites W1859657706 @default.
- W2058223290 cites W1961560739 @default.
- W2058223290 cites W1963889969 @default.
- W2058223290 cites W1967667819 @default.
- W2058223290 cites W1968516742 @default.
- W2058223290 cites W1968552183 @default.
- W2058223290 cites W1969228261 @default.
- W2058223290 cites W1970266671 @default.
- W2058223290 cites W1974706661 @default.
- W2058223290 cites W1975548607 @default.
- W2058223290 cites W1977088495 @default.
- W2058223290 cites W1977829734 @default.
- W2058223290 cites W1977997142 @default.
- W2058223290 cites W1978054036 @default.
- W2058223290 cites W1978754000 @default.
- W2058223290 cites W1979385111 @default.
- W2058223290 cites W1981142961 @default.
- W2058223290 cites W1981458656 @default.
- W2058223290 cites W1981504084 @default.
- W2058223290 cites W1981844581 @default.
- W2058223290 cites W1983218764 @default.
- W2058223290 cites W1987577420 @default.
- W2058223290 cites W1989136612 @default.
- W2058223290 cites W1990286658 @default.
- W2058223290 cites W1990441769 @default.
- W2058223290 cites W1992632955 @default.
- W2058223290 cites W1992875057 @default.
- W2058223290 cites W1993026474 @default.
- W2058223290 cites W1993580403 @default.
- W2058223290 cites W1995702059 @default.
- W2058223290 cites W2003785817 @default.
- W2058223290 cites W2008280357 @default.
- W2058223290 cites W2011158459 @default.
- W2058223290 cites W2011287943 @default.
- W2058223290 cites W2012046347 @default.
- W2058223290 cites W2015174686 @default.
- W2058223290 cites W2015821968 @default.
- W2058223290 cites W2019239618 @default.
- W2058223290 cites W2021845150 @default.
- W2058223290 cites W2022539205 @default.
- W2058223290 cites W2022811243 @default.
- W2058223290 cites W2024414745 @default.
- W2058223290 cites W2026959390 @default.
- W2058223290 cites W2033651349 @default.
- W2058223290 cites W2037382834 @default.
- W2058223290 cites W2038731398 @default.
- W2058223290 cites W2040099443 @default.
- W2058223290 cites W2041065032 @default.
- W2058223290 cites W2043757833 @default.
- W2058223290 cites W2043895957 @default.
- W2058223290 cites W2045090937 @default.
- W2058223290 cites W2047151494 @default.
- W2058223290 cites W2052714004 @default.
- W2058223290 cites W2061060103 @default.
- W2058223290 cites W2062284662 @default.
- W2058223290 cites W2062584177 @default.
- W2058223290 cites W2065588235 @default.
- W2058223290 cites W2067328670 @default.
- W2058223290 cites W2068077324 @default.
- W2058223290 cites W2068288569 @default.
- W2058223290 cites W2069334332 @default.
- W2058223290 cites W2072668354 @default.
- W2058223290 cites W2073234328 @default.
- W2058223290 cites W2077436902 @default.
- W2058223290 cites W2078710083 @default.
- W2058223290 cites W2082981258 @default.
- W2058223290 cites W2083740738 @default.
- W2058223290 cites W2083753924 @default.
- W2058223290 cites W2084089807 @default.
- W2058223290 cites W2084745121 @default.
- W2058223290 cites W2088857928 @default.
- W2058223290 cites W2091204939 @default.
- W2058223290 cites W2094020226 @default.
- W2058223290 cites W2095085201 @default.
- W2058223290 cites W2096391864 @default.
- W2058223290 cites W2097316296 @default.
- W2058223290 cites W2097976666 @default.
- W2058223290 cites W2099798537 @default.
- W2058223290 cites W2100285961 @default.
- W2058223290 cites W2101100530 @default.
- W2058223290 cites W2102107922 @default.
- W2058223290 cites W2102433010 @default.
- W2058223290 cites W2107419622 @default.
- W2058223290 cites W2108655384 @default.
- W2058223290 cites W2110555186 @default.
- W2058223290 cites W2111420919 @default.