FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058227667> ?p ?o ?g. }

• W2058227667 endingPage "310" @default.
• W2058227667 startingPage "302" @default.
• W2058227667 abstract "Reactive oxygen species (ROS) are constantly produced in the human body and are involved in the pathogenesis of aging, cardiovascular diseases, and cancer. Emerging evidence indicates that oxidation and inhibition of protein tyrosine phosphatases (PTPs) are critical for ROS signal transduction. However, the role of individual PTPs in ROS signaling remains unclear. Here, we demonstrated that the receptor-like PTPα (RPTPα) was an effector of H2O2, the most stable form of ROS. H2O2 at nontoxic concentration rapidly induced the association of RPTPα with Src family kinases, platelet-derived growth factor receptor-β, and protein kinase D in various cultured cells, although it markedly suppressed RPTPα phosphorylation on Tyr-789. We further identified that RPTPα selectively regulated the signal transduction pathways induced by H2O2. Particularly, RPTPα was required for the activation of protein kinase D and for the modulation of p130Cas tyrosine phosphorylation in response to H2O2. In contrast, the H2O2-induced inactivation of Src family kinases and suppression of paxillin phosphorylation on Tyr-118 were both largely independent of RPTPα. Our findings indicate that H2O2 signaling pathways are selectively regulated by RPTPα in cells, which may provide new insights into the functional regulation of ROS signal transduction by PTPs." @default.
• W2058227667 created "2016-06-24" @default.
• W2058227667 creator A5016709186 @default.
• W2058227667 creator A5024886981 @default.
• W2058227667 creator A5047609552 @default.
• W2058227667 creator A5087273420 @default.
• W2058227667 date "2006-07-01" @default.
• W2058227667 modified "2023-10-16" @default.
• W2058227667 title "Selective regulation of hydrogen peroxide signaling by receptor tyrosine phosphatase-α" @default.
• W2058227667 cites W113714250 @default.
• W2058227667 cites W1572891678 @default.
• W2058227667 cites W1831542174 @default.
• W2058227667 cites W1968332969 @default.
• W2058227667 cites W1971058672 @default.
• W2058227667 cites W1972747412 @default.
• W2058227667 cites W1989899772 @default.
• W2058227667 cites W1997916074 @default.
• W2058227667 cites W2000271974 @default.
• W2058227667 cites W2003655244 @default.
• W2058227667 cites W2007334843 @default.
• W2058227667 cites W2008381968 @default.
• W2058227667 cites W2011605309 @default.
• W2058227667 cites W2023879112 @default.
• W2058227667 cites W2026761013 @default.
• W2058227667 cites W2027566693 @default.
• W2058227667 cites W2029869071 @default.
• W2058227667 cites W2033444434 @default.
• W2058227667 cites W2034152669 @default.
• W2058227667 cites W2037291219 @default.
• W2058227667 cites W2037403173 @default.
• W2058227667 cites W2038585252 @default.
• W2058227667 cites W2040923416 @default.
• W2058227667 cites W2043549608 @default.
• W2058227667 cites W2049636133 @default.
• W2058227667 cites W2059044084 @default.
• W2058227667 cites W2066451762 @default.
• W2058227667 cites W2084434864 @default.
• W2058227667 cites W2085664820 @default.
• W2058227667 cites W2091312661 @default.
• W2058227667 cites W2102041759 @default.
• W2058227667 cites W2109698138 @default.
• W2058227667 cites W2110565948 @default.
• W2058227667 cites W2114449882 @default.
• W2058227667 cites W2117372001 @default.
• W2058227667 cites W2120805921 @default.
• W2058227667 cites W2127792712 @default.
• W2058227667 cites W2135633069 @default.
• W2058227667 cites W2136573391 @default.
• W2058227667 cites W2139755134 @default.
• W2058227667 cites W2148340118 @default.
• W2058227667 cites W2150601162 @default.
• W2058227667 cites W2156320225 @default.
• W2058227667 cites W2163187840 @default.
• W2058227667 cites W2164682544 @default.
• W2058227667 cites W2165259997 @default.
• W2058227667 cites W2337833709 @default.
• W2058227667 doi "https://doi.org/10.1016/j.freeradbiomed.2006.04.011" @default.
• W2058227667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16814111" @default.
• W2058227667 hasPublicationYear "2006" @default.
• W2058227667 type Work @default.
• W2058227667 sameAs 2058227667 @default.
• W2058227667 citedByCount "24" @default.
• W2058227667 countsByYear W20582276672012 @default.
• W2058227667 countsByYear W20582276672013 @default.
• W2058227667 countsByYear W20582276672016 @default.
• W2058227667 countsByYear W20582276672017 @default.
• W2058227667 countsByYear W20582276672019 @default.
• W2058227667 countsByYear W20582276672020 @default.
• W2058227667 countsByYear W20582276672022 @default.
• W2058227667 crossrefType "journal-article" @default.
• W2058227667 hasAuthorship W2058227667A5016709186 @default.
• W2058227667 hasAuthorship W2058227667A5024886981 @default.
• W2058227667 hasAuthorship W2058227667A5047609552 @default.
• W2058227667 hasAuthorship W2058227667A5087273420 @default.
• W2058227667 hasConcept C101544691 @default.
• W2058227667 hasConcept C108636557 @default.
• W2058227667 hasConcept C11960822 @default.
• W2058227667 hasConcept C178666793 @default.
• W2058227667 hasConcept C184235292 @default.
• W2058227667 hasConcept C185592680 @default.
• W2058227667 hasConcept C2777553839 @default.
• W2058227667 hasConcept C42362537 @default.
• W2058227667 hasConcept C48349386 @default.
• W2058227667 hasConcept C55493867 @default.
• W2058227667 hasConcept C62478195 @default.
• W2058227667 hasConcept C85528070 @default.
• W2058227667 hasConcept C86803240 @default.
• W2058227667 hasConcept C95444343 @default.
• W2058227667 hasConceptScore W2058227667C101544691 @default.
• W2058227667 hasConceptScore W2058227667C108636557 @default.
• W2058227667 hasConceptScore W2058227667C11960822 @default.
• W2058227667 hasConceptScore W2058227667C178666793 @default.
• W2058227667 hasConceptScore W2058227667C184235292 @default.
• W2058227667 hasConceptScore W2058227667C185592680 @default.
• W2058227667 hasConceptScore W2058227667C2777553839 @default.
• W2058227667 hasConceptScore W2058227667C42362537 @default.
• W2058227667 hasConceptScore W2058227667C48349386 @default.
• W2058227667 hasConceptScore W2058227667C55493867 @default.

• next