Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058229367> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2058229367 endingPage "966" @default.
- W2058229367 startingPage "962" @default.
- W2058229367 abstract "Abstract BM 41.440 (1‐hexadecylmercapto‐2‐methoxymethyl‐ rac ‐glycero‐3‐phosphocholine) is a new thioether phospholipid, which has been shown to possess antineoplastic, antimetastatic, anti‐invasive and immunomodulating properties in serveral tumor models. The mechanism whereby this compound exerts its direct antineoplastic effect is thought to be related to specific interference with the normal phospholipid metabolism, preferentially of neoplastic cells. BM 41.440 was evaluated in a multicenter phase I study in patients (pts) with refractory cancers. In phase I A, 34 pts were orally treated with doses ranging from 0.5 to 7.0 mg/kg body weight (bw). Three different formulations were tested. The maximum‐tolerated dose (MTD) was ca. 5 mg/kg bw. The limiting side effects were nausea and vomiting. There was no evidence for systemic toxicities like myelosuppression, nephro‐, neuro‐, hepatotoxicity or hematological side effects. The current phase I B is designed to determine the MTD of BM 41.440 administered orally on a daily schedule for at least eight weeks. So far, 19 pts have entered this trial at dose levels ranging from 1.0 to 5.0 mg/kg bw/day. Some pts receiving 1.0 and 2.5 mg/kg bw/day, respectively, have been treated, up to now, for more than nine months. Clinical progress was followed with at‐least‐weekly blood counts, chemistry profiles, urine analysis, liver function tests and recordings of side effects. Tumor parameters were evaluated at eight‐week intervals. In parallel, pharmacokinetic investigations were performed in some pts in phase I A and IB. First results on tolerability and therapeutic efficacy of the long‐term BM 41.440 treatment are reported in this intermediate evaluation." @default.
- W2058229367 created "2016-06-24" @default.
- W2058229367 creator A5001655709 @default.
- W2058229367 creator A5004624917 @default.
- W2058229367 creator A5009556973 @default.
- W2058229367 creator A5019550618 @default.
- W2058229367 creator A5025105470 @default.
- W2058229367 creator A5071979715 @default.
- W2058229367 creator A5081013332 @default.
- W2058229367 date "1987-11-01" @default.
- W2058229367 modified "2023-09-30" @default.
- W2058229367 title "Phase I trial of the thioether phospholipid analogue BM 41.440 in cancer patients" @default.
- W2058229367 cites W1528816585 @default.
- W2058229367 cites W1602490654 @default.
- W2058229367 cites W1650989939 @default.
- W2058229367 cites W1751785630 @default.
- W2058229367 cites W1957284165 @default.
- W2058229367 cites W1976595473 @default.
- W2058229367 cites W2010618838 @default.
- W2058229367 cites W2060422769 @default.
- W2058229367 cites W2068177788 @default.
- W2058229367 cites W2070732633 @default.
- W2058229367 cites W2162756412 @default.
- W2058229367 cites W2345950204 @default.
- W2058229367 cites W2413849811 @default.
- W2058229367 cites W2911348381 @default.
- W2058229367 cites W4231562630 @default.
- W2058229367 cites W4243118840 @default.
- W2058229367 doi "https://doi.org/10.1007/bf02535565" @default.
- W2058229367 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3328028" @default.
- W2058229367 hasPublicationYear "1987" @default.
- W2058229367 type Work @default.
- W2058229367 sameAs 2058229367 @default.
- W2058229367 citedByCount "33" @default.
- W2058229367 countsByYear W20582293672013 @default.
- W2058229367 countsByYear W20582293672015 @default.
- W2058229367 countsByYear W20582293672019 @default.
- W2058229367 countsByYear W20582293672022 @default.
- W2058229367 crossrefType "journal-article" @default.
- W2058229367 hasAuthorship W2058229367A5001655709 @default.
- W2058229367 hasAuthorship W2058229367A5004624917 @default.
- W2058229367 hasAuthorship W2058229367A5009556973 @default.
- W2058229367 hasAuthorship W2058229367A5019550618 @default.
- W2058229367 hasAuthorship W2058229367A5025105470 @default.
- W2058229367 hasAuthorship W2058229367A5071979715 @default.
- W2058229367 hasAuthorship W2058229367A5081013332 @default.
- W2058229367 hasConcept C112705442 @default.
- W2058229367 hasConcept C121608353 @default.
- W2058229367 hasConcept C126322002 @default.
- W2058229367 hasConcept C185592680 @default.
- W2058229367 hasConcept C2778918659 @default.
- W2058229367 hasConcept C2780580376 @default.
- W2058229367 hasConcept C2780852908 @default.
- W2058229367 hasConcept C41625074 @default.
- W2058229367 hasConcept C55493867 @default.
- W2058229367 hasConcept C71924100 @default.
- W2058229367 hasConcept C90924648 @default.
- W2058229367 hasConcept C98274493 @default.
- W2058229367 hasConceptScore W2058229367C112705442 @default.
- W2058229367 hasConceptScore W2058229367C121608353 @default.
- W2058229367 hasConceptScore W2058229367C126322002 @default.
- W2058229367 hasConceptScore W2058229367C185592680 @default.
- W2058229367 hasConceptScore W2058229367C2778918659 @default.
- W2058229367 hasConceptScore W2058229367C2780580376 @default.
- W2058229367 hasConceptScore W2058229367C2780852908 @default.
- W2058229367 hasConceptScore W2058229367C41625074 @default.
- W2058229367 hasConceptScore W2058229367C55493867 @default.
- W2058229367 hasConceptScore W2058229367C71924100 @default.
- W2058229367 hasConceptScore W2058229367C90924648 @default.
- W2058229367 hasConceptScore W2058229367C98274493 @default.
- W2058229367 hasIssue "11" @default.
- W2058229367 hasLocation W20582293671 @default.
- W2058229367 hasLocation W20582293672 @default.
- W2058229367 hasOpenAccess W2058229367 @default.
- W2058229367 hasPrimaryLocation W20582293671 @default.
- W2058229367 hasRelatedWork W148728087 @default.
- W2058229367 hasRelatedWork W2074629895 @default.
- W2058229367 hasRelatedWork W2328289339 @default.
- W2058229367 hasRelatedWork W2376132146 @default.
- W2058229367 hasRelatedWork W2387364079 @default.
- W2058229367 hasRelatedWork W2417803418 @default.
- W2058229367 hasRelatedWork W2468000090 @default.
- W2058229367 hasRelatedWork W2748952813 @default.
- W2058229367 hasRelatedWork W2899084033 @default.
- W2058229367 hasRelatedWork W3142684436 @default.
- W2058229367 hasVolume "22" @default.
- W2058229367 isParatext "false" @default.
- W2058229367 isRetracted "false" @default.
- W2058229367 magId "2058229367" @default.
- W2058229367 workType "article" @default.