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• W2058230154 abstract "The oral administration of myelin basic protein (MBP) to Lewis rats prior to an encephalitogenic challenge resulted in total inhibition or a significant delay in the onset of experimental autoimmune encephalomyelitis (EAE). In vitro lymphocyte proliferative responses to MBP were significantly decreased in MBP-fed rats when compared with vehicle-fed controls. Suppression of EAE and in vitro proliferative responses to MBP were observed to be antigen specific, since oral feeding of a control protein exerted no suppressive effect. Moreover, the specificity of MBP-induced oral tolerance was shown to be species specific, since feeding guinea pig MBP (GPMBP) or human MBP (HuMBP) induced protection only against a GPMBP or HuMBP challenge, respectively. Conversely, Lewis rats could not be orally tolerized to the self antigen rat MBP." @default.
• W2058230154 created "2016-06-24" @default.
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• W2058230154 date "1988-04-01" @default.
• W2058230154 modified "2023-09-24" @default.
• W2058230154 title "Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein" @default.
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• W2058230154 doi "https://doi.org/10.1016/0008-8749(88)90305-x" @default.
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