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- W2058230816 abstract "Combinatorial libraries offer new sources of compounds for the research of pharmacological agents such as receptor ligands, enzyme inhibitors or substrates and antibody-binding epitopes. The present review stresses the main roles played by both physico-chemical analysis, particularly when complex mixture of compounds are synthesized as libraries, and biological analysis from which active compounds are identified. After a brief discussion of semantic problems related to the designation of the product mixtures, the physico-chemical analysis of mixtures is reviewed with special emphasis on mass spectrometric techniques. These methods are able both to give a representative view of a library composition and to identify single critical compounds in large libraries. Then the biological screening of such combinatorial libraries is critically discussed with respect to the power and limitations of the methods used for the identification of the active components. Special attention is given to the complex process of library deconvolution. It is pointed out that while combinatorial techniques have evolved towards sophisticated high-tech methods, simple and robust biochemical tests should be used to deconvolute. From a large panel of published examples, a set of trends are identified which should help investigators to choose the most appropriate assay for the discovery of new entities." @default.
- W2058230816 created "2016-06-24" @default.
- W2058230816 creator A5030697398 @default.
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- W2058230816 creator A5041552166 @default.
- W2058230816 creator A5052791160 @default.
- W2058230816 creator A5060129050 @default.
- W2058230816 date "1999-04-01" @default.
- W2058230816 modified "2023-10-18" @default.
- W2058230816 title "Physico-chemical and biological analysis of true combinatorial libraries" @default.
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