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• W2058232286 abstract "Fiber cells of the lens are interconnected by an extensive network of gap junctions containing α 3 (Cx46) and α 8 (Cx50) connexins. A specific role for these connexins in lens homeostasis is not known. To determine the contribution of these connexins to lens function, we used impedance techniques to study cell-to-cell coupling in lenses from homozygous α 3 knockout (−/−), heterozygous (+/−), and wild-type (+/+) mice. Western blots and immunofluorescence data indicated that α 8 remained at similar levels in the three classes of lenses, whereas α 3 was approximately 50% of the normal level in the +/− lenses, and it was absent from the −/− lenses. Moreover, the data from +/+ lenses suggest that a cleavage of connexins occurs abruptly between the peripheral shell of differentiating fibers (DF) and the inner core of mature fibers (MF). The appearance of the cleaved connexins was correlated to a change in the coupling conductance. In −/− lenses the coupling conductance of MF was zero, and these fibers were depolarized by about 30 mV from normal (≈−65 mV). The DF remained coupled, but the conductance was reduced to 30–35% of normal. However, the gap junctions in the DF of α 3 −/− lenses remained sensitive to pH. We conclude that α 3 connexin is necessary for the coupling of central fibers to peripheral cells, and that this coupling is essential for fiber cell homeostasis because uncoupled MF depolarize and subsequently become opaque." @default.
• W2058232286 created "2016-06-24" @default.
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• W2058232286 date "1998-12-22" @default.
• W2058232286 modified "2023-10-10" @default.
• W2058232286 title "Gap junctional coupling in lenses lacking α ₃ connexin" @default.
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• W2058232286 doi "https://doi.org/10.1073/pnas.95.26.15303" @default.
• W2058232286 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/28038" @default.
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