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• W2058234089 abstract "Lead (Pb), an occupational and environmental toxicant, is known to induce immunomodulatory effects resulting in lowered resistance to infectious micro-organisms and altered levels of immunoglobulins in humans. Preferential activation of type-2 helper T cells and inhibition of type-1 T-cell activation is considered a cellular mechanism for the Pb-induced immune alteration, which has not been investigated well in humans. Lead's influence on in vivo balance between type-1 and type-2 activities was assessed among workers exposed to Pb through battery manufacturing in Korea. Serum IgE levels were significantly higher in the workers with a blood Pb level (PbB) of > or = 30 microg/dL than in the workers with a PbB of < 30 microg/dL. Furthermore, the serum IgE concentrations significantly correlated with PbB although no significant relationship between PbB and serum interleukin-4 or interferon gamma levels was observed. The present study indicates that elevation of IgE levels may be an immunologic index for Pb-induced in vivo toxicities, potentially involved with progression of various allergic diseases in humans." @default.
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• W2058234089 date "2004-05-01" @default.
• W2058234089 modified "2023-10-16" @default.
• W2058234089 title "Serum IgE elevation correlates with blood lead levels in battery manufacturing workers" @default.
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• W2058234089 doi "https://doi.org/10.1191/0960327104ht442oa" @default.
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