Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058237744> ?p ?o ?g. }
Showing items 1 to 57 of
57
with 100 items per page.
- W2058237744 endingPage "476" @default.
- W2058237744 startingPage "469" @default.
- W2058237744 abstract "Numerous pathologic studies in the 1990's have shown atherosclerosis to be a chronic inflammatory disorder. This new insight and the advent of new plaque-stabilizing drugs, in particular antilipemic agents (statins), have led to an increased clinical interest in the development of new imaging modalities. These are aimed at visualizing the inflammatory atherosclerotic wall lesion as reflecting the active progression of the disease process and at identifying so-called vulnerable or high-risk lesions that are associated with a higher rate of vascular complications. A diagnostic modality currently undergoing investigation in terms of its potential for the diagnostic assessment of atherosclerosis is contrast-enhanced magnetic resonance imaging (MRI) using certain blood pool contrast media such as ultrasmall superparamagnetic iron oxide (USPIO) particles. Endothelial dysfunction and macrophage infiltration are two crucial pathomechanisms of atherosclerosis and these mechanisms also underlie the accumulation of iron oxide particles in experimental and human atherosclerotic lesions. Experimental results furthermore suggest that there is selective uptake of iron oxide by thrombi. The following experimental MR imaging techniques have a potential for providing complementary diagnostic information in assessing atherosclerotic lesions: 1. Unenhanced MRI for visualizing vulnerable plaques (wall thickness, fibrous cap, lipid core). 2. Visualization of the vessel lumen and quantitative assessment of stenosis using iron-oxide-enhanced MR angiography. 3. Delayed MRI studies for the functional characterization of inflammatory lesions (T 2 -effects produced by iron oxide uptake in macrophages of inflammatory lesions) with a potential for identifying mural thrombus as a sign of plaque rupture (T 1 -effects produced by binding of iron oxide to the thrombus). This article presents the experimental and initial clinical results obtained with iron-oxide-enhanced MRI of atherosclerotic lesions." @default.
- W2058237744 created "2016-06-24" @default.
- W2058237744 creator A5043968198 @default.
- W2058237744 date "2003-04-01" @default.
- W2058237744 modified "2023-09-25" @default.
- W2058237744 title "Eisenoxidverstärkte MRT inflammatorischeratherosklerotischer Läsionen: Übersichtexperimenteller und erster klinischer Ergebnisse" @default.
- W2058237744 doi "https://doi.org/10.1055/s-2003-38434" @default.
- W2058237744 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12677500" @default.
- W2058237744 hasPublicationYear "2003" @default.
- W2058237744 type Work @default.
- W2058237744 sameAs 2058237744 @default.
- W2058237744 citedByCount "10" @default.
- W2058237744 countsByYear W20582377442012 @default.
- W2058237744 crossrefType "journal-article" @default.
- W2058237744 hasAuthorship W2058237744A5043968198 @default.
- W2058237744 hasConcept C126322002 @default.
- W2058237744 hasConcept C126838900 @default.
- W2058237744 hasConcept C131631996 @default.
- W2058237744 hasConcept C142724271 @default.
- W2058237744 hasConcept C143409427 @default.
- W2058237744 hasConcept C2776914184 @default.
- W2058237744 hasConcept C2779179121 @default.
- W2058237744 hasConcept C2780007028 @default.
- W2058237744 hasConcept C2781156865 @default.
- W2058237744 hasConcept C71924100 @default.
- W2058237744 hasConceptScore W2058237744C126322002 @default.
- W2058237744 hasConceptScore W2058237744C126838900 @default.
- W2058237744 hasConceptScore W2058237744C131631996 @default.
- W2058237744 hasConceptScore W2058237744C142724271 @default.
- W2058237744 hasConceptScore W2058237744C143409427 @default.
- W2058237744 hasConceptScore W2058237744C2776914184 @default.
- W2058237744 hasConceptScore W2058237744C2779179121 @default.
- W2058237744 hasConceptScore W2058237744C2780007028 @default.
- W2058237744 hasConceptScore W2058237744C2781156865 @default.
- W2058237744 hasConceptScore W2058237744C71924100 @default.
- W2058237744 hasIssue "4" @default.
- W2058237744 hasLocation W20582377441 @default.
- W2058237744 hasLocation W20582377442 @default.
- W2058237744 hasOpenAccess W2058237744 @default.
- W2058237744 hasPrimaryLocation W20582377441 @default.
- W2058237744 hasRelatedWork W1991369147 @default.
- W2058237744 hasRelatedWork W2036320343 @default.
- W2058237744 hasRelatedWork W2064141351 @default.
- W2058237744 hasRelatedWork W2071036143 @default.
- W2058237744 hasRelatedWork W2075231447 @default.
- W2058237744 hasRelatedWork W2400727047 @default.
- W2058237744 hasRelatedWork W2411153813 @default.
- W2058237744 hasRelatedWork W2613508851 @default.
- W2058237744 hasRelatedWork W2972979826 @default.
- W2058237744 hasRelatedWork W3140751645 @default.
- W2058237744 hasVolume "175" @default.
- W2058237744 isParatext "false" @default.
- W2058237744 isRetracted "false" @default.
- W2058237744 magId "2058237744" @default.
- W2058237744 workType "article" @default.