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- W2058249192 abstract "We performed in vitro studies to investigate the potential interaction of benzodiazepines with cloned human opioid receptor subtypes. Midazolam, chlordiazepoxide, and diazepam directly displaced [3H]-diprenorphine binding from κ and δ receptors, but not μ receptors, whereas flumazenil was inactive. These benzodiazepines also stimulated 35S-GTPγS binding in membranes containing human κ receptors, and the effect of midazolam was prevented by a selective κ antagonist. Midazolam was also weakly active at δ-receptor activation, whereas all three were inactive at μ receptors. The results suggest that the analgesic efficacy reported for intrathecal benzodiazepines may be attributed, in part, to direct interaction with κ-opioid receptors." @default.
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- W2058249192 date "2001-08-01" @default.
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- W2058249192 title "The Effects of Benzodiazepines on Human Opioid Receptor Binding and Function" @default.
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- W2058249192 doi "https://doi.org/10.1097/00000539-200108000-00024" @default.
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