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• W2058252007 abstract "Noise-induced hearing loss is a major cause of acquired hearing loss around the world and pharmacological approaches to protecting the ear from noise are under investigation. Noise results in a combination of mechanical and metabolic damage pathways in the cochlea. The Src family of protein tyrosine kinases could be active in both pathways and Src inhibitors have successfully prevented noise-induced cochlear damage and hearing loss in animal models. The long-term goal is to optimize delivery methods into the cochlea to reduce invasiveness and limit side-effects before human clinical testing can be considered. At their current early stage of research investigation, Src inhibitors represent an exciting class of compounds for inclusion in a multifaceted pharmacological approach to protecting the ear from noise." @default.
• W2058252007 created "2016-06-24" @default.
• W2058252007 creator A5082207030 @default.
• W2058252007 date "2015-06-01" @default.
• W2058252007 modified "2023-09-23" @default.
• W2058252007 title "Protection from noise-induced hearing loss with Src inhibitors" @default.
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• W2058252007 doi "https://doi.org/10.1016/j.drudis.2015.01.010" @default.
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