Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058252791> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2058252791 endingPage "214" @default.
- W2058252791 startingPage "203" @default.
- W2058252791 abstract "The catalytic activity of CYP1A isoforms and the effect of mammalian CYP1A-specific inhibitors in liver S9 fractions were studied in an agnathan (River lamprey, Lampetra fluviatilis, 30-33 cm) and in two species of teleost fish (European flounder, Pleuronectes flesus, 11-18 cm and common eel, Anguilla anguilla, 31-48 cm). Ethoxyresorufin O-deethylation (EROD), caffeine N-demethylation/C-oxidation and phenacetin O-deethylation (POD) activity increased 3-4-fold in flounders and 17-46-fold in eels, 5 days after fish were injected (i.p.) with 100 mg kg(-1) benzo(a)pyrene (B[a]P). In lampreys, basal EROD activity was very low and no increase in activity was observed following exposure to B[a]P. While the apparent Michaelis constant (K(m)) for each assay showed only small changes after B[a]P injection, maximum reaction velocity (V(max)) values increased by up to 19- and 84-fold for EROD activity, 4- and 35-fold for caffeine-related metabolism and 4- and 19-fold for POD activity in flounders and eels, respectively. The mammalian CYP1A2 inhibitor furafylline (50 microM-1 mM) reduced activity in the EROD, caffeine and POD assays to 65, 21 and 20% of control values in flounders and to 85, 10 and 5% of control values in eels, respectively. By contrast, low concentrations (0.025-0.050 microM) of the mammalian CYP1A1 inhibitor ellipticine completely abolished EROD activity, but had no effect (up to 1 mM) on caffeine metabolism or POD activity in either species. While the inhibitor studies strongly suggest that two separate enzymes are present in flounders and eels, the monophasic Michaelis-Menten kinetics obtained in all the assays imply that only a single CYP1A protein is present that has substrate and inhibitor specificities characteristic of both mammalian CYP1A1 and CYP1A2 isoforms." @default.
- W2058252791 created "2016-06-24" @default.
- W2058252791 creator A5014018469 @default.
- W2058252791 creator A5081826044 @default.
- W2058252791 creator A5090962042 @default.
- W2058252791 date "2000-02-01" @default.
- W2058252791 modified "2023-09-25" @default.
- W2058252791 title "Catalytic properties of CYP1A isoforms in the liver of an agnathan (Lampetra fluviatilis) and two species of teleost (Pleuronectes flesus, Anguilla anguilla)" @default.
- W2058252791 cites W1951469402 @default.
- W2058252791 cites W1964198497 @default.
- W2058252791 cites W1971315597 @default.
- W2058252791 cites W1974135197 @default.
- W2058252791 cites W1986286660 @default.
- W2058252791 cites W1990874048 @default.
- W2058252791 cites W2002421635 @default.
- W2058252791 cites W2006998778 @default.
- W2058252791 cites W2023087412 @default.
- W2058252791 cites W2023341739 @default.
- W2058252791 cites W2030794394 @default.
- W2058252791 cites W2037812043 @default.
- W2058252791 cites W2048349264 @default.
- W2058252791 cites W2053296813 @default.
- W2058252791 cites W2053481602 @default.
- W2058252791 cites W2073123212 @default.
- W2058252791 cites W2077868914 @default.
- W2058252791 cites W2085887410 @default.
- W2058252791 cites W2095173308 @default.
- W2058252791 cites W2106109834 @default.
- W2058252791 cites W2135536512 @default.
- W2058252791 cites W246383350 @default.
- W2058252791 cites W4240401901 @default.
- W2058252791 cites W4256006582 @default.
- W2058252791 doi "https://doi.org/10.1016/s0742-8413(99)00105-x" @default.
- W2058252791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11790342" @default.
- W2058252791 hasPublicationYear "2000" @default.
- W2058252791 type Work @default.
- W2058252791 sameAs 2058252791 @default.
- W2058252791 citedByCount "9" @default.
- W2058252791 crossrefType "journal-article" @default.
- W2058252791 hasAuthorship W2058252791A5014018469 @default.
- W2058252791 hasAuthorship W2058252791A5081826044 @default.
- W2058252791 hasAuthorship W2058252791A5090962042 @default.
- W2058252791 hasConcept C126322002 @default.
- W2058252791 hasConcept C134018914 @default.
- W2058252791 hasConcept C185592680 @default.
- W2058252791 hasConcept C2776367567 @default.
- W2058252791 hasConcept C2778307567 @default.
- W2058252791 hasConcept C2778311276 @default.
- W2058252791 hasConcept C2778500429 @default.
- W2058252791 hasConcept C2779701871 @default.
- W2058252791 hasConcept C2780417240 @default.
- W2058252791 hasConcept C2781011932 @default.
- W2058252791 hasConcept C2909208804 @default.
- W2058252791 hasConcept C505870484 @default.
- W2058252791 hasConcept C526171541 @default.
- W2058252791 hasConcept C55493867 @default.
- W2058252791 hasConcept C62231903 @default.
- W2058252791 hasConcept C71924100 @default.
- W2058252791 hasConcept C86745063 @default.
- W2058252791 hasConcept C86803240 @default.
- W2058252791 hasConceptScore W2058252791C126322002 @default.
- W2058252791 hasConceptScore W2058252791C134018914 @default.
- W2058252791 hasConceptScore W2058252791C185592680 @default.
- W2058252791 hasConceptScore W2058252791C2776367567 @default.
- W2058252791 hasConceptScore W2058252791C2778307567 @default.
- W2058252791 hasConceptScore W2058252791C2778311276 @default.
- W2058252791 hasConceptScore W2058252791C2778500429 @default.
- W2058252791 hasConceptScore W2058252791C2779701871 @default.
- W2058252791 hasConceptScore W2058252791C2780417240 @default.
- W2058252791 hasConceptScore W2058252791C2781011932 @default.
- W2058252791 hasConceptScore W2058252791C2909208804 @default.
- W2058252791 hasConceptScore W2058252791C505870484 @default.
- W2058252791 hasConceptScore W2058252791C526171541 @default.
- W2058252791 hasConceptScore W2058252791C55493867 @default.
- W2058252791 hasConceptScore W2058252791C62231903 @default.
- W2058252791 hasConceptScore W2058252791C71924100 @default.
- W2058252791 hasConceptScore W2058252791C86745063 @default.
- W2058252791 hasConceptScore W2058252791C86803240 @default.
- W2058252791 hasIssue "2" @default.
- W2058252791 hasLocation W20582527911 @default.
- W2058252791 hasLocation W20582527912 @default.
- W2058252791 hasOpenAccess W2058252791 @default.
- W2058252791 hasPrimaryLocation W20582527911 @default.
- W2058252791 hasRelatedWork W1989307175 @default.
- W2058252791 hasRelatedWork W2002421635 @default.
- W2058252791 hasRelatedWork W2002472190 @default.
- W2058252791 hasRelatedWork W2003594111 @default.
- W2058252791 hasRelatedWork W2028506307 @default.
- W2058252791 hasRelatedWork W2058252791 @default.
- W2058252791 hasRelatedWork W2093424283 @default.
- W2058252791 hasRelatedWork W2157009522 @default.
- W2058252791 hasRelatedWork W2257272873 @default.
- W2058252791 hasRelatedWork W2412205203 @default.
- W2058252791 hasVolume "125" @default.
- W2058252791 isParatext "false" @default.
- W2058252791 isRetracted "false" @default.
- W2058252791 magId "2058252791" @default.
- W2058252791 workType "article" @default.