FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058252938> ?p ?o ?g. }

• W2058252938 endingPage "5208" @default.
• W2058252938 startingPage "5201" @default.
• W2058252938 abstract "ABSTRACT Human immunodeficiency virus type 1 (HIV-1) entry is mediated by the consecutive interaction of the envelope glycoprotein gp120 with CD4 and a coreceptor such as CCR5 or CXCR4. The CCR5 coreceptor is used by the most commonly transmitted HIV-1 strains that often persist throughout the course of infection. Compounds targeting CCR5-mediated entry are a novel class of drugs being developed to treat HIV-1 infection. In this study, we have identified the mechanism of action of two inhibitors of CCR5 function, SCH-350581 (AD101) and SCH-351125 (SCH-C). AD101 is more potent than SCH-C at inhibiting HIV-1 replication in primary lymphocytes, as well as viral entry and gp120 binding to cell lines. Both molecules also block the binding of several anti-CCR5 monoclonal antibodies that recognize epitopes in the second extracellular loop of CCR5. Alanine mutagenesis of the transmembrane domain of CCR5 suggests that AD101 and SCH-C bind to overlapping but nonidentical sites within a putative ligand-binding cavity formed by transmembrane helices 1, 2, 3, and 7. We propose that the binding of small molecules to the transmembrane domain of CCR5 may disrupt the conformation of its extracellular domain, thereby inhibiting ligand binding to CCR5." @default.
• W2058252938 created "2016-06-24" @default.
• W2058252938 creator A5010940613 @default.
• W2058252938 creator A5015361909 @default.
• W2058252938 creator A5018721125 @default.
• W2058252938 creator A5022966532 @default.
• W2058252938 creator A5031152546 @default.
• W2058252938 creator A5034683864 @default.
• W2058252938 creator A5039798032 @default.
• W2058252938 creator A5041333172 @default.
• W2058252938 creator A5046401324 @default.
• W2058252938 creator A5049314631 @default.
• W2058252938 creator A5049386332 @default.
• W2058252938 creator A5054636334 @default.
• W2058252938 creator A5061095609 @default.
• W2058252938 creator A5073735734 @default.
• W2058252938 creator A5088229002 @default.
• W2058252938 date "2003-05-01" @default.
• W2058252938 modified "2023-09-28" @default.
• W2058252938 title "Analysis of the Mechanism by Which the Small-Molecule CCR5 Antagonists SCH-351125 and SCH-350581 Inhibit Human Immunodeficiency Virus Type 1 Entry" @default.
• W2058252938 cites W1562621350 @default.
• W2058252938 cites W1619354717 @default.
• W2058252938 cites W1641098735 @default.
• W2058252938 cites W1894273024 @default.
• W2058252938 cites W1955657492 @default.
• W2058252938 cites W1966515400 @default.
• W2058252938 cites W1973473416 @default.
• W2058252938 cites W1984811742 @default.
• W2058252938 cites W1990515631 @default.
• W2058252938 cites W2002824205 @default.
• W2058252938 cites W2006734012 @default.
• W2058252938 cites W2007021820 @default.
• W2058252938 cites W2018964839 @default.
• W2058252938 cites W2020643931 @default.
• W2058252938 cites W2021699930 @default.
• W2058252938 cites W2026444780 @default.
• W2058252938 cites W2028309086 @default.
• W2058252938 cites W2042802165 @default.
• W2058252938 cites W2044004371 @default.
• W2058252938 cites W2067635356 @default.
• W2058252938 cites W2067964854 @default.
• W2058252938 cites W2082180266 @default.
• W2058252938 cites W2089138872 @default.
• W2058252938 cites W2090630729 @default.
• W2058252938 cites W2107656195 @default.
• W2058252938 cites W2110182256 @default.
• W2058252938 cites W2129875326 @default.
• W2058252938 cites W2132870230 @default.
• W2058252938 cites W2135739941 @default.
• W2058252938 cites W2138758139 @default.
• W2058252938 cites W2140478082 @default.
• W2058252938 cites W2141003640 @default.
• W2058252938 cites W2142655367 @default.
• W2058252938 cites W2147169218 @default.
• W2058252938 cites W2149963584 @default.
• W2058252938 cites W2150833007 @default.
• W2058252938 cites W2154728363 @default.
• W2058252938 cites W2156117117 @default.
• W2058252938 cites W2158850631 @default.
• W2058252938 cites W2322224643 @default.
• W2058252938 cites W2333512232 @default.
• W2058252938 cites W4211151736 @default.
• W2058252938 doi "https://doi.org/10.1128/jvi.77.9.5201-5208.2003" @default.
• W2058252938 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/153966" @default.
• W2058252938 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12692222" @default.
• W2058252938 hasPublicationYear "2003" @default.
• W2058252938 type Work @default.
• W2058252938 sameAs 2058252938 @default.
• W2058252938 citedByCount "198" @default.
• W2058252938 countsByYear W20582529382012 @default.
• W2058252938 countsByYear W20582529382013 @default.
• W2058252938 countsByYear W20582529382014 @default.
• W2058252938 countsByYear W20582529382015 @default.
• W2058252938 countsByYear W20582529382016 @default.
• W2058252938 countsByYear W20582529382018 @default.
• W2058252938 countsByYear W20582529382019 @default.
• W2058252938 countsByYear W20582529382020 @default.
• W2058252938 countsByYear W20582529382021 @default.
• W2058252938 countsByYear W20582529382022 @default.
• W2058252938 crossrefType "journal-article" @default.
• W2058252938 hasAuthorship W2058252938A5010940613 @default.
• W2058252938 hasAuthorship W2058252938A5015361909 @default.
• W2058252938 hasAuthorship W2058252938A5018721125 @default.
• W2058252938 hasAuthorship W2058252938A5022966532 @default.
• W2058252938 hasAuthorship W2058252938A5031152546 @default.
• W2058252938 hasAuthorship W2058252938A5034683864 @default.
• W2058252938 hasAuthorship W2058252938A5039798032 @default.
• W2058252938 hasAuthorship W2058252938A5041333172 @default.
• W2058252938 hasAuthorship W2058252938A5046401324 @default.
• W2058252938 hasAuthorship W2058252938A5049314631 @default.
• W2058252938 hasAuthorship W2058252938A5049386332 @default.
• W2058252938 hasAuthorship W2058252938A5054636334 @default.
• W2058252938 hasAuthorship W2058252938A5061095609 @default.
• W2058252938 hasAuthorship W2058252938A5073735734 @default.
• W2058252938 hasAuthorship W2058252938A5088229002 @default.
• W2058252938 hasBestOaLocation W20582529381 @default.
• W2058252938 hasConcept C104317684 @default.
• W2058252938 hasConcept C107824862 @default.

• next