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- W2058258002 abstract "The C7-cyclitol 2-epi-5-epi-valiolone is the first precursor of the cyclitol moiety of the alpha-glucosidase inhibitor acarbose in Actinoplanes sp. SE50. The 2-epi-5-epi-valiolone becomes phosphorylated at C7 by the ATP dependent kinase AcbM prior to the next modifications. Preliminary data gave evidences that the AcbO protein could catalyse the first modification step of 2-epi-5-epi-valiolone-7-phosphate. Therefore, the AcbO protein, the encoding gene of which is also part of the acbKMLNOC operon, was overproduced and purified. Indeed the purified protein catalysed the 2-epimerisation of 2-epi-5-epi-valiolone-7-phosphate. The chemical structure of the purified reaction product was proven by nuclear magnetic resonance spectroscopy to be 5-epi-valiolone-7-phosphate." @default.
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- W2058258002 date "2003-03-20" @default.
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- W2058258002 title "The acarbose-biosynthetic enzyme AcbO from <i>Actinoplanes</i> sp. SE 50/110 is a 2-<i>epi</i> -5-<i>epi</i> -valiolone-7-phosphate 2-epimerase" @default.
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- W2058258002 doi "https://doi.org/10.1016/s0014-5793(03)00221-7" @default.
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