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• W2058260900 abstract "T-cell activation is essential for initiation and control of immune system function. T cells are activated by interaction of cell-surface antigen receptors with major histocompatibility complex (MHC) proteins on the surface of other cells. Studies using soluble oligomers of MHC-peptide complexes and other types of receptor cross-linking agents have supported an activation mechanism that involves T cell receptor clustering. Receptor clustering induced by incubation of T cells with MHC-peptide oligomers leads to the induction of T-cell activation processes, including downregulation of engaged receptors and upregulation of the cell-surface proteins CD69 and CD25. Dose-response curves for these T-cell activation markers are bell-shaped, with different maxima and midpoints, depending on the valency of the soluble oligomer used. In this study, we have analyzed the activation behavior using a mathematical model that describes the binding of multivalent ligands to cell-surface receptors. We show that a simple equilibrium binding model accurately describes the activation data for CD4(+) T cells treated with MHC-peptide oligomers of varying valency. The model can be used to predict activation and binding behavior for T cells and MHC oligomers with different properties." @default.
• W2058260900 created "2016-06-24" @default.
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• W2058260900 date "2001-11-01" @default.
• W2058260900 modified "2023-10-16" @default.
• W2058260900 title "T-Cell Activation by Soluble MHC Oligomers Can Be Described by a Two-Parameter Binding Model" @default.
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• W2058260900 doi "https://doi.org/10.1016/s0006-3495(01)75899-7" @default.
• W2058260900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1301723" @default.
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