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- W2058261503 abstract "Significance The envelope subunit gp41 is an attractive target for therapeutic intervention against HIV-1. Interfering with the interaction between the heptad-repeat regions of gp41 is a promising approach to inhibit HIV-1 fusion to the host cell membrane. Here, we present an alternative rational design and protein-engineering approach to produce highly stable single-chain proteins that accurately mimic the trimeric coiled-coil surface of the gp41 N-terminal heptad repeat. This approach has a strong potential for development to HIV-1 drugs, vaccines, or microbicides and could be extendable to the design of proteins interfering with other types of coiled-coil interactions." @default.
- W2058261503 created "2016-06-24" @default.
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- W2058261503 date "2014-12-08" @default.
- W2058261503 modified "2023-09-27" @default.
- W2058261503 title "Single-chain protein mimetics of the N-terminal heptad-repeat region of gp41 with potential as anti–HIV-1 drugs" @default.
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- W2058261503 doi "https://doi.org/10.1073/pnas.1413592112" @default.
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