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• W2058285100 abstract "Histones are synthesized and become a part of the chromatin as early as the first cleavage in sea urchins. Reproducible changes in relative amounts of individual histone fractions synthesized are observed during development. A new and electrophoretically distinct very lysine rich fraction appears at hatching in Arbacia and in the early gastrula of Lytechinus. When RNA synthesis is blocked by actinomycin D, maternal mRNA alone can direct a quantitatively and qualitatively changing pattern of histone synthesis as cleavage proceeds. Inhibition of DNA synthesis by hydroxyurea reduces synthesis of histones; the arginine-rich histones are more severely affected than the lysine-rich ones." @default.
• W2058285100 created "2016-06-24" @default.
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• W2058285100 date "1974-02-01" @default.
• W2058285100 modified "2023-10-11" @default.
• W2058285100 title "Histones and histone synthesis in sea urchin development" @default.
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• W2058285100 doi "https://doi.org/10.1016/0012-1606(74)90052-9" @default.
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