FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058288237> ?p ?o ?g. }

• W2058288237 endingPage "161" @default.
• W2058288237 startingPage "150" @default.
• W2058288237 abstract "The present study examined brain dopamine D2 and D4 receptor and tyrosine hydroxylase (TH) mRNA expression in chronic high-fat diet-induced obese (cDIO) and obese-resistant (cDR) mice. Twenty-eight mice were fed a high-fat diet (HF: 40% of calories from fat) for 6 weeks and then classified as cDIO (n = 8) or cDR (n = 8) mice according to the highest and lowest body weight gainers, respectively. Seven mice were fed a low-fat diet (LF: 10% of calories from fat) and used as controls. After 20 weeks of feeding, visceral fat per gram of initial body weight was significantly higher in the cDIO group (ratio: 0.25, 0.09, and 0.04; P < 0.01 cDIO vs. cDR and LF, respectively). Using quantitative in situ hybridization techniques, the levels of D2 and D4 receptor and tyrosine hydroxylase (TH) mRNAs were measured in multiple brain sections. The cDIO mice had a significantly higher level of D2 receptor mRNA expression in the core of the nucleus accumbens (AcbC, +16%) and ventral parts of caudate putamen (CPu, 21% and 24%) compared to the cDR and LF mice. The levels of D2 receptor mRNA expression in the AcbC and ventromedial part of the CPu were positively related to the final body weight. This study is the first to systematically examine the D4 mRNA expression in the mouse brain using in situ hybridization method. D4 receptor mRNA expression in the ventromedial hypothalamic nucleus (VMH) and the ventral part of the lateral septal nucleus were also significantly higher in the cDIO mice compared to the cDR and LF mice (+31% and +60%; P < 0.05). TH mRNA expression was significantly higher in the ventral tegmental area (+17%, P ≤ 0.05) and locus caeruleus (+15%, P ≤ 0.05) of the cDIO mice compared to cDR mice. In conclusion, this study has demonstrated differentially regulated levels of D2 and D4 receptor and TH mRNA expression in specific brain regions of cDIO and cDR mice. It provides evidence that D4 receptors may play an important role influencing satiety via the mesohypothalamic pathway while the D2 receptor may regulate reward and motor centers via mesolimbic and nigrostriatal pathways. These findings contribute to the understanding of the role of these receptors in susceptibility, or resistance, to diet-induced obesity." @default.
• W2058288237 created "2016-06-24" @default.
• W2058288237 creator A5002681207 @default.
• W2058288237 creator A5053294607 @default.
• W2058288237 creator A5075042346 @default.
• W2058288237 creator A5082502371 @default.
• W2058288237 creator A5087877333 @default.
• W2058288237 date "2005-04-01" @default.
• W2058288237 modified "2023-10-13" @default.
• W2058288237 title "Differential expression of dopamine D2 and D4 receptor and tyrosine hydroxylase mRNA in mice prone, or resistant, to chronic high-fat diet-induced obesity" @default.
• W2058288237 cites W129633775 @default.
• W2058288237 cites W1511397211 @default.
• W2058288237 cites W1831301545 @default.
• W2058288237 cites W1884887148 @default.
• W2058288237 cites W1965358029 @default.
• W2058288237 cites W1965780343 @default.
• W2058288237 cites W1966806663 @default.
• W2058288237 cites W1972178738 @default.
• W2058288237 cites W1974360159 @default.
• W2058288237 cites W1977869470 @default.
• W2058288237 cites W1978453350 @default.
• W2058288237 cites W1979170976 @default.
• W2058288237 cites W1982176103 @default.
• W2058288237 cites W1987735575 @default.
• W2058288237 cites W1992744313 @default.
• W2058288237 cites W1992822500 @default.
• W2058288237 cites W1998670974 @default.
• W2058288237 cites W2004456056 @default.
• W2058288237 cites W2005925690 @default.
• W2058288237 cites W2008879626 @default.
• W2058288237 cites W2011444761 @default.
• W2058288237 cites W2019189591 @default.
• W2058288237 cites W2022406285 @default.
• W2058288237 cites W2024262458 @default.
• W2058288237 cites W2031418574 @default.
• W2058288237 cites W2035928537 @default.
• W2058288237 cites W2038281778 @default.
• W2058288237 cites W2042698372 @default.
• W2058288237 cites W2044399205 @default.
• W2058288237 cites W2059230444 @default.
• W2058288237 cites W2061757665 @default.
• W2058288237 cites W2062431407 @default.
• W2058288237 cites W2063397055 @default.
• W2058288237 cites W2077447899 @default.
• W2058288237 cites W2081710533 @default.
• W2058288237 cites W2092432949 @default.
• W2058288237 cites W2093566021 @default.
• W2058288237 cites W2150205118 @default.
• W2058288237 cites W2162911486 @default.
• W2058288237 cites W2163415363 @default.
• W2058288237 cites W2164125772 @default.
• W2058288237 cites W2174764226 @default.
• W2058288237 cites W2347590257 @default.
• W2058288237 cites W4256109724 @default.
• W2058288237 doi "https://doi.org/10.1016/j.molbrainres.2004.12.013" @default.
• W2058288237 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15857678" @default.
• W2058288237 hasPublicationYear "2005" @default.
• W2058288237 type Work @default.
• W2058288237 sameAs 2058288237 @default.
• W2058288237 citedByCount "105" @default.
• W2058288237 countsByYear W20582882372012 @default.
• W2058288237 countsByYear W20582882372013 @default.
• W2058288237 countsByYear W20582882372014 @default.
• W2058288237 countsByYear W20582882372015 @default.
• W2058288237 countsByYear W20582882372016 @default.
• W2058288237 countsByYear W20582882372017 @default.
• W2058288237 countsByYear W20582882372018 @default.
• W2058288237 countsByYear W20582882372019 @default.
• W2058288237 countsByYear W20582882372020 @default.
• W2058288237 countsByYear W20582882372021 @default.
• W2058288237 countsByYear W20582882372022 @default.
• W2058288237 countsByYear W20582882372023 @default.
• W2058288237 crossrefType "journal-article" @default.
• W2058288237 hasAuthorship W2058288237A5002681207 @default.
• W2058288237 hasAuthorship W2058288237A5053294607 @default.
• W2058288237 hasAuthorship W2058288237A5075042346 @default.
• W2058288237 hasAuthorship W2058288237A5082502371 @default.
• W2058288237 hasAuthorship W2058288237A5087877333 @default.
• W2058288237 hasConcept C104317684 @default.
• W2058288237 hasConcept C105580179 @default.
• W2058288237 hasConcept C126322002 @default.
• W2058288237 hasConcept C134018914 @default.
• W2058288237 hasConcept C159167319 @default.
• W2058288237 hasConcept C2776552330 @default.
• W2058288237 hasConcept C40438245 @default.
• W2058288237 hasConcept C44208683 @default.
• W2058288237 hasConcept C513476851 @default.
• W2058288237 hasConcept C55493867 @default.
• W2058288237 hasConcept C71924100 @default.
• W2058288237 hasConcept C81439078 @default.
• W2058288237 hasConcept C86803240 @default.
• W2058288237 hasConceptScore W2058288237C104317684 @default.
• W2058288237 hasConceptScore W2058288237C105580179 @default.
• W2058288237 hasConceptScore W2058288237C126322002 @default.
• W2058288237 hasConceptScore W2058288237C134018914 @default.
• W2058288237 hasConceptScore W2058288237C159167319 @default.
• W2058288237 hasConceptScore W2058288237C2776552330 @default.
• W2058288237 hasConceptScore W2058288237C40438245 @default.

• next