Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058299306> ?p ?o ?g. }
- W2058299306 endingPage "1339" @default.
- W2058299306 startingPage "1322" @default.
- W2058299306 abstract "The Xenopus gene crescent encodes a member of the secreted Frizzled-related protein (sFRP) family and is expressed in the head organizer region. However, the target and function of Crescent in early development are not well understood. Here, we describe a role of Crescent in the regulation of convergent extension movements (CEMs) during gastrulation and neurulation. We show that overexpression of Crescent in whole embryos or animal caps inhibits CEMs without affecting tissue specification. Consistent with this, Crescent efficiently forms complexes with Xwnt11 and Xwnt5a, in contrast to another sFRP, Frzb1. As expected, the inhibitory effect of Crescent or Xwnt11 on CEMs is cancelled when both proteins are coexpressed in the neuroectoderm. Interestingly, when coexpressed in the dorsal mesoderm, the activity of Xwnt11 is rather enhanced by Crescent. Supporting this finding, the inhibition of CEMs by Crescent in mesodermalized but not neuralized animal caps is reversed by the dominant-negative form of Cdc42, a putative mediator of Wnt/Ca2+ pathway. Antisense morpholino oligos for Crescent impair neural plate closure and elicit microcephalic embryos with a shortened trunk without affecting early tissue specification. These data suggest a potential role for Crescent in head formation by regulating a non-canonical Wnt pathway positively in the adjacent posterior mesoderm and negatively in the overlying anterior neuroectoderm." @default.
- W2058299306 created "2016-06-24" @default.
- W2058299306 creator A5007105432 @default.
- W2058299306 creator A5016865613 @default.
- W2058299306 creator A5081563397 @default.
- W2058299306 creator A5082820156 @default.
- W2058299306 creator A5091839025 @default.
- W2058299306 date "2005-12-01" @default.
- W2058299306 modified "2023-10-16" @default.
- W2058299306 title "Role of crescent in convergent extension movements by modulating Wnt signaling in early Xenopus embryogenesis" @default.
- W2058299306 cites W1526492609 @default.
- W2058299306 cites W1529745075 @default.
- W2058299306 cites W1542499527 @default.
- W2058299306 cites W1549691444 @default.
- W2058299306 cites W1563810352 @default.
- W2058299306 cites W1589588578 @default.
- W2058299306 cites W1664587663 @default.
- W2058299306 cites W1833815327 @default.
- W2058299306 cites W1941036671 @default.
- W2058299306 cites W1944789371 @default.
- W2058299306 cites W1956332901 @default.
- W2058299306 cites W1965927965 @default.
- W2058299306 cites W1969910714 @default.
- W2058299306 cites W1972666776 @default.
- W2058299306 cites W1974712344 @default.
- W2058299306 cites W1977498553 @default.
- W2058299306 cites W1977814055 @default.
- W2058299306 cites W1978047924 @default.
- W2058299306 cites W1978379357 @default.
- W2058299306 cites W1979243347 @default.
- W2058299306 cites W1982709013 @default.
- W2058299306 cites W1986864689 @default.
- W2058299306 cites W1989918771 @default.
- W2058299306 cites W1998902161 @default.
- W2058299306 cites W2000775801 @default.
- W2058299306 cites W2001835391 @default.
- W2058299306 cites W2006671195 @default.
- W2058299306 cites W2008575029 @default.
- W2058299306 cites W2008822708 @default.
- W2058299306 cites W2010054905 @default.
- W2058299306 cites W2018448892 @default.
- W2058299306 cites W2025853097 @default.
- W2058299306 cites W2029634472 @default.
- W2058299306 cites W2034133599 @default.
- W2058299306 cites W2050615859 @default.
- W2058299306 cites W2052374677 @default.
- W2058299306 cites W2054477929 @default.
- W2058299306 cites W2057811123 @default.
- W2058299306 cites W2071135527 @default.
- W2058299306 cites W2071268339 @default.
- W2058299306 cites W2082676215 @default.
- W2058299306 cites W2084649822 @default.
- W2058299306 cites W2090667868 @default.
- W2058299306 cites W2092664596 @default.
- W2058299306 cites W2093521812 @default.
- W2058299306 cites W2095537830 @default.
- W2058299306 cites W2096143207 @default.
- W2058299306 cites W2097315204 @default.
- W2058299306 cites W2099353036 @default.
- W2058299306 cites W2100829481 @default.
- W2058299306 cites W2104204293 @default.
- W2058299306 cites W2106636692 @default.
- W2058299306 cites W2115686163 @default.
- W2058299306 cites W2127280898 @default.
- W2058299306 cites W2134485689 @default.
- W2058299306 cites W2138959037 @default.
- W2058299306 cites W2149810608 @default.
- W2058299306 cites W2161481085 @default.
- W2058299306 cites W2164964874 @default.
- W2058299306 cites W2165459158 @default.
- W2058299306 cites W2167864615 @default.
- W2058299306 cites W2187739293 @default.
- W2058299306 cites W2395950107 @default.
- W2058299306 doi "https://doi.org/10.1016/j.mod.2005.06.002" @default.
- W2058299306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16274967" @default.
- W2058299306 hasPublicationYear "2005" @default.
- W2058299306 type Work @default.
- W2058299306 sameAs 2058299306 @default.
- W2058299306 citedByCount "25" @default.
- W2058299306 countsByYear W20582993062012 @default.
- W2058299306 countsByYear W20582993062014 @default.
- W2058299306 countsByYear W20582993062015 @default.
- W2058299306 countsByYear W20582993062016 @default.
- W2058299306 countsByYear W20582993062017 @default.
- W2058299306 countsByYear W20582993062018 @default.
- W2058299306 countsByYear W20582993062022 @default.
- W2058299306 countsByYear W20582993062023 @default.
- W2058299306 crossrefType "journal-article" @default.
- W2058299306 hasAuthorship W2058299306A5007105432 @default.
- W2058299306 hasAuthorship W2058299306A5016865613 @default.
- W2058299306 hasAuthorship W2058299306A5081563397 @default.
- W2058299306 hasAuthorship W2058299306A5082820156 @default.
- W2058299306 hasAuthorship W2058299306A5091839025 @default.
- W2058299306 hasConcept C104317684 @default.
- W2058299306 hasConcept C129536746 @default.
- W2058299306 hasConcept C135073763 @default.
- W2058299306 hasConcept C136571751 @default.
- W2058299306 hasConcept C137620995 @default.