FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058309856> ?p ?o ?g. }

• W2058309856 endingPage "590" @default.
• W2058309856 startingPage "579" @default.
• W2058309856 abstract "The secreted frizzled-related protein 1 gene (SFRP1) encodes a Wnt/beta-catenin signaling antagonist and frequently is inactivated by promoter methylation in many tumors. However, the role of SFRP1 in hepatocellular carcinoma (HCC) is not clear. Therefore, the authors investigated whether methylation of the SFRP1 promoter is common in HCC and whether it may influence SFRP1 expression.Four HCC cell lines, 54 HCCs, 42 cirrhotic livers, 21 livers with chronic hepatitis, and 15 normal control tissues were analyzed for 1) SFRP1 promoter methylation by using methylation-specific polymerase chain reaction analysis and bisulfite sequencing, 2) SFRP1 messenger RNA expression by using quantitative reverse transcriptase-polymerase chain reaction analysis, and 3) loss of heterozygosity (LOH) by using microsatellite markers flanking the SFRP1 locus. HCC cells were treated with the demethylating agent 5-aza-2'-deoxycytidine to determine whether it could restore SFRP1 expression.SFRP1 promoter methylation was observed in 75%, 48.2%, 21.4%, 14.3% and 0% in HCC cell lines, primary HCCs, cirrhotic livers, livers with chronic hepatitis, and normal control tissues, respectively. Methylation of the SFRP1 promoter region in HCCs increased significantly compared with control tissues. All samples with SFRP1 methylation showed down-regulation of SFRP1 expression. Demethylation treatment with 5-aza-2'-deoxycytidine in HCC cells restored SFRP1 expression. Moreover, LOH of markers D8S505 and D8S1722 was found in 25% and 27.6% of the informative samples, respectively.The current results suggested that promoter hypermethylation of SFRP1 is a common event in HCC and plays an important role in the regulation of SFRP1 expression. In addition to methylation-mediated down-regulation of SFRP1, LOH also may play a role." @default.
• W2058309856 created "2016-06-24" @default.
• W2058309856 creator A5000010847 @default.
• W2058309856 creator A5015383125 @default.
• W2058309856 creator A5052554861 @default.
• W2058309856 creator A5056719429 @default.
• W2058309856 creator A5068257787 @default.
• W2058309856 creator A5081333878 @default.
• W2058309856 creator A5087964242 @default.
• W2058309856 date "2006-01-01" @default.
• W2058309856 modified "2023-10-17" @default.
• W2058309856 title "Promoter methylation of the secreted frizzled-related protein 1 geneSFRP1 is frequent in hepatocellular carcinoma" @default.
• W2058309856 cites W1542110088 @default.
• W2058309856 cites W1836452880 @default.
• W2058309856 cites W1966448677 @default.
• W2058309856 cites W1972856645 @default.
• W2058309856 cites W1977706798 @default.
• W2058309856 cites W1985146880 @default.
• W2058309856 cites W1990563353 @default.
• W2058309856 cites W1994465394 @default.
• W2058309856 cites W2000931643 @default.
• W2058309856 cites W2010231795 @default.
• W2058309856 cites W2012039807 @default.
• W2058309856 cites W2012323824 @default.
• W2058309856 cites W2015314925 @default.
• W2058309856 cites W2024095083 @default.
• W2058309856 cites W2024432674 @default.
• W2058309856 cites W2036126626 @default.
• W2058309856 cites W2038623988 @default.
• W2058309856 cites W2040257851 @default.
• W2058309856 cites W2042191940 @default.
• W2058309856 cites W2048005397 @default.
• W2058309856 cites W2051521408 @default.
• W2058309856 cites W2056372251 @default.
• W2058309856 cites W2056927214 @default.
• W2058309856 cites W2060893815 @default.
• W2058309856 cites W2067273401 @default.
• W2058309856 cites W2067874905 @default.
• W2058309856 cites W2067973442 @default.
• W2058309856 cites W2069142607 @default.
• W2058309856 cites W2069545469 @default.
• W2058309856 cites W2074137258 @default.
• W2058309856 cites W2080560721 @default.
• W2058309856 cites W2085023377 @default.
• W2058309856 cites W2090194040 @default.
• W2058309856 cites W2093677236 @default.
• W2058309856 cites W2107277218 @default.
• W2058309856 cites W2107745042 @default.
• W2058309856 cites W2107972234 @default.
• W2058309856 cites W2117100349 @default.
• W2058309856 cites W2117799366 @default.
• W2058309856 cites W2122051016 @default.
• W2058309856 cites W2127280898 @default.
• W2058309856 cites W2127787503 @default.
• W2058309856 cites W2128573905 @default.
• W2058309856 cites W2144300167 @default.
• W2058309856 cites W2148074532 @default.
• W2058309856 cites W2149129433 @default.
• W2058309856 cites W2150162153 @default.
• W2058309856 cites W2162726435 @default.
• W2058309856 cites W2164247688 @default.
• W2058309856 cites W2167638513 @default.
• W2058309856 cites W2313449389 @default.
• W2058309856 cites W2321119966 @default.
• W2058309856 doi "https://doi.org/10.1002/cncr.22023" @default.
• W2058309856 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16795071" @default.
• W2058309856 hasPublicationYear "2006" @default.
• W2058309856 type Work @default.
• W2058309856 sameAs 2058309856 @default.
• W2058309856 citedByCount "95" @default.
• W2058309856 countsByYear W20583098562012 @default.
• W2058309856 countsByYear W20583098562013 @default.
• W2058309856 countsByYear W20583098562014 @default.
• W2058309856 countsByYear W20583098562015 @default.
• W2058309856 countsByYear W20583098562016 @default.
• W2058309856 countsByYear W20583098562017 @default.
• W2058309856 countsByYear W20583098562018 @default.
• W2058309856 countsByYear W20583098562019 @default.
• W2058309856 countsByYear W20583098562020 @default.
• W2058309856 countsByYear W20583098562022 @default.
• W2058309856 countsByYear W20583098562023 @default.
• W2058309856 crossrefType "journal-article" @default.
• W2058309856 hasAuthorship W2058309856A5000010847 @default.
• W2058309856 hasAuthorship W2058309856A5015383125 @default.
• W2058309856 hasAuthorship W2058309856A5052554861 @default.
• W2058309856 hasAuthorship W2058309856A5056719429 @default.
• W2058309856 hasAuthorship W2058309856A5068257787 @default.
• W2058309856 hasAuthorship W2058309856A5081333878 @default.
• W2058309856 hasAuthorship W2058309856A5087964242 @default.
• W2058309856 hasBestOaLocation W20583098561 @default.
• W2058309856 hasConcept C104317684 @default.
• W2058309856 hasConcept C150194340 @default.
• W2058309856 hasConcept C153911025 @default.
• W2058309856 hasConcept C190727270 @default.
• W2058309856 hasConcept C2778019345 @default.
• W2058309856 hasConcept C2779277951 @default.
• W2058309856 hasConcept C2779314089 @default.
• W2058309856 hasConcept C33288867 @default.

• next