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- W2058311580 endingPage "784" @default.
- W2058311580 startingPage "774" @default.
- W2058311580 abstract "Summary The K ennard principle suggests that the immature brain should be more able to recover from injury than the more developed brain. Curiously, preterm infants continue to have a high rate of debilitating neurodevelopmental handicaps despite a progressive improvement in structural damage to the brain, from acute necrotic injury of the periventricular white matter, with axonal loss in historical cohorts, to diffuse gliosis with trivial axonal damage. In the present review we examine recent evidence that disability after preterm birth is largely mediated by disturbed development of neuronal connections. Potential mechanisms include impaired white matter maturation associated with gliosis, suboptimal neuronal maturation, adverse effects of infection/inflammation on the cell environment, exposure to clinical therapies that modulate brain function (including maternal glucocorticoids), upregulation of physiological apoptosis and loss or misprogramming of progenitor cells in the subventricular zone. These findings suggest that insults during this critical phase alter the trajectory of brain development and that a key focus of basic science and clinical research should be to understand neuronal connectivity, as well as the triggers of cell death." @default.
- W2058311580 created "2016-06-24" @default.
- W2058311580 creator A5031560169 @default.
- W2058311580 creator A5033506933 @default.
- W2058311580 creator A5039019537 @default.
- W2058311580 creator A5047041488 @default.
- W2058311580 creator A5074576479 @default.
- W2058311580 creator A5083955925 @default.
- W2058311580 date "2013-10-27" @default.
- W2058311580 modified "2023-10-04" @default.
- W2058311580 title "Neural plasticity and the Kennard principle: does it work for the preterm brain?" @default.
- W2058311580 cites W1546401219 @default.
- W2058311580 cites W1563556120 @default.
- W2058311580 cites W1565499968 @default.
- W2058311580 cites W1948168563 @default.
- W2058311580 cites W1969433430 @default.
- W2058311580 cites W1970345382 @default.
- W2058311580 cites W1970723879 @default.
- W2058311580 cites W1971615126 @default.
- W2058311580 cites W1973636838 @default.
- W2058311580 cites W1975631984 @default.
- W2058311580 cites W1976517826 @default.
- W2058311580 cites W1977415794 @default.
- W2058311580 cites W1979919872 @default.
- W2058311580 cites W1980670889 @default.
- W2058311580 cites W1980893110 @default.
- W2058311580 cites W1984718847 @default.
- W2058311580 cites W1987256326 @default.
- W2058311580 cites W1990164686 @default.
- W2058311580 cites W1992205789 @default.
- W2058311580 cites W1994882363 @default.
- W2058311580 cites W1994997559 @default.
- W2058311580 cites W1996527158 @default.
- W2058311580 cites W1997946324 @default.
- W2058311580 cites W1999375126 @default.
- W2058311580 cites W2000268407 @default.
- W2058311580 cites W2006291460 @default.
- W2058311580 cites W2008148132 @default.
- W2058311580 cites W2008564181 @default.
- W2058311580 cites W2009656354 @default.
- W2058311580 cites W2015626542 @default.
- W2058311580 cites W2016693709 @default.
- W2058311580 cites W2017975444 @default.
- W2058311580 cites W2019174681 @default.
- W2058311580 cites W2020279210 @default.
- W2058311580 cites W2022916613 @default.
- W2058311580 cites W2024894183 @default.
- W2058311580 cites W2025429732 @default.
- W2058311580 cites W2025783622 @default.
- W2058311580 cites W2031420920 @default.
- W2058311580 cites W2032861830 @default.
- W2058311580 cites W2034406849 @default.
- W2058311580 cites W2035196855 @default.
- W2058311580 cites W2038436037 @default.
- W2058311580 cites W2039476938 @default.
- W2058311580 cites W2044013578 @default.
- W2058311580 cites W2044947593 @default.
- W2058311580 cites W2046062795 @default.
- W2058311580 cites W2049095415 @default.
- W2058311580 cites W2050860036 @default.
- W2058311580 cites W2052180393 @default.
- W2058311580 cites W2056694524 @default.
- W2058311580 cites W2056777387 @default.
- W2058311580 cites W2056985474 @default.
- W2058311580 cites W2058162289 @default.
- W2058311580 cites W2060223196 @default.
- W2058311580 cites W2061860553 @default.
- W2058311580 cites W2065607090 @default.
- W2058311580 cites W2065829750 @default.
- W2058311580 cites W2069112518 @default.
- W2058311580 cites W2071214406 @default.
- W2058311580 cites W2074732691 @default.
- W2058311580 cites W2076026006 @default.
- W2058311580 cites W2076605578 @default.
- W2058311580 cites W2076674910 @default.
- W2058311580 cites W2077550185 @default.
- W2058311580 cites W2077819377 @default.
- W2058311580 cites W2078897383 @default.
- W2058311580 cites W2079012288 @default.
- W2058311580 cites W2080288957 @default.
- W2058311580 cites W2080930754 @default.
- W2058311580 cites W2081446987 @default.
- W2058311580 cites W2086517182 @default.
- W2058311580 cites W2087390477 @default.
- W2058311580 cites W2088546536 @default.
- W2058311580 cites W2089808957 @default.
- W2058311580 cites W2091242408 @default.
- W2058311580 cites W2093057971 @default.
- W2058311580 cites W2094337546 @default.
- W2058311580 cites W2100554620 @default.
- W2058311580 cites W2106608131 @default.
- W2058311580 cites W2111447973 @default.
- W2058311580 cites W2114785548 @default.
- W2058311580 cites W2116587655 @default.
- W2058311580 cites W2118802114 @default.
- W2058311580 cites W2119258332 @default.
- W2058311580 cites W2123293994 @default.
- W2058311580 cites W2126807687 @default.