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• W2058312234 abstract "Background Previous studies have shown the genetic association of tumor necrosis factor (TNF)-α polymorphisms and susceptibility to primary biliary cirrhosis (PBC), but the results of individual studies have remained contradictory. Therefore, a meta-analysis was carried out to evaluate comprehensively the association of TNF-α polymorphisms and susceptibility to PBC. Methods The relevant published articles were searched in PubMed, EMBASE, and Cochrane library. Data were extracted using standardized forms and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for each study. Pooled data were estimated by fixed-effects and random-effects models when appropriate. We analyzed the association between the ‘A’ allele at position −308(rs1800629) and −238(rs361525) and the risk of PBC. Results We examined eight publications, showing that all eight studies discussed the TNF-α −308(rs1800629) polymorphism; four studies were relevant with −238(rs361525). No significant associations were found between the ‘A’ allele frequency of rs1800629 and rs361525 and the risk of PBC in the overall population (OR=0.89, 95% CI 0.71–1.11, P=0.91; OR=0.98, 95% CI 0.66–1.47, P=0.93) and in Whites (OR=0.94, 95% CI 0.74–1.19, P=0.58; OR=1.01, 95% CI 0.64–1.59, P=0.97). Besides, it was also found that the genotype (AA+AG vs. GG, GG+AG vs. AA) was not linked to susceptibility to PBC. Conclusion The meta-analysis indicated that none of these two polymorphisms (−308G/A and −238G/A) showed any significant association with the risk of PBC." @default.
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• W2058312234 date "2012-12-01" @default.
• W2058312234 modified "2023-09-25" @default.
• W2058312234 title "Effect of the polymorphisms of tumor necrosis factor-α gene on the susceptibility to primary biliary cirrhosis" @default.
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• W2058312234 doi "https://doi.org/10.1097/meg.0b013e3283581f2e" @default.
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