FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058317622> ?p ?o ?g. }

• W2058317622 endingPage "201" @default.
• W2058317622 startingPage "199" @default.
• W2058317622 abstract "Site-directed mutagenesis of the large fragment of DNA polymerase I (Klenow fragment) yielded two mutant proteins lacking 3',5'-exonuclease activity but having normal polymerase activity. Crystallographic analysis of the mutant proteins showed that neither had any alteration in protein structure other than the expected changes at the mutation sites. These results confirmed the presumed location of the exonuclease active site on the small domain of Klenow fragment and its physical separation from the polymerase active site. An anomalous scattering difference Fourier of a complex of the wild-type enzyme with divalent manganese ion and deoxythymidine monophosphate showed that the exonuclease active site has binding sites for two divalent metal ions. The properties of the mutant proteins suggest that one metal ion plays a role in substrate binding while the other is involved in catalysis of the exonuclease reaction." @default.
• W2058317622 created "2016-06-24" @default.
• W2058317622 creator A5005980770 @default.
• W2058317622 creator A5022075115 @default.
• W2058317622 creator A5022211670 @default.
• W2058317622 creator A5028954365 @default.
• W2058317622 creator A5042405014 @default.
• W2058317622 creator A5064929293 @default.
• W2058317622 creator A5072614956 @default.
• W2058317622 date "1988-04-08" @default.
• W2058317622 modified "2023-09-27" @default.
• W2058317622 title "Genetic and Crystallographic Studies of the 3′,5′-Exonucleolytic Site of DNA Polymerase I" @default.
• W2058317622 cites W1256872718 @default.
• W2058317622 cites W1489974113 @default.
• W2058317622 cites W1986052161 @default.
• W2058317622 cites W2015931172 @default.
• W2058317622 cites W2035650458 @default.
• W2058317622 cites W2036931150 @default.
• W2058317622 cites W2045776421 @default.
• W2058317622 cites W2052485080 @default.
• W2058317622 cites W2168463294 @default.
• W2058317622 cites W2315909620 @default.
• W2058317622 cites W97826703 @default.
• W2058317622 doi "https://doi.org/10.1126/science.2832946" @default.
• W2058317622 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2832946" @default.
• W2058317622 hasPublicationYear "1988" @default.
• W2058317622 type Work @default.
• W2058317622 sameAs 2058317622 @default.
• W2058317622 citedByCount "332" @default.
• W2058317622 countsByYear W20583176222012 @default.
• W2058317622 countsByYear W20583176222013 @default.
• W2058317622 countsByYear W20583176222014 @default.
• W2058317622 countsByYear W20583176222015 @default.
• W2058317622 countsByYear W20583176222016 @default.
• W2058317622 countsByYear W20583176222017 @default.
• W2058317622 countsByYear W20583176222018 @default.
• W2058317622 countsByYear W20583176222020 @default.
• W2058317622 countsByYear W20583176222021 @default.
• W2058317622 countsByYear W20583176222022 @default.
• W2058317622 countsByYear W20583176222023 @default.
• W2058317622 crossrefType "journal-article" @default.
• W2058317622 hasAuthorship W2058317622A5005980770 @default.
• W2058317622 hasAuthorship W2058317622A5022075115 @default.
• W2058317622 hasAuthorship W2058317622A5022211670 @default.
• W2058317622 hasAuthorship W2058317622A5028954365 @default.
• W2058317622 hasAuthorship W2058317622A5042405014 @default.
• W2058317622 hasAuthorship W2058317622A5064929293 @default.
• W2058317622 hasAuthorship W2058317622A5072614956 @default.
• W2058317622 hasConcept C103408237 @default.
• W2058317622 hasConcept C104317684 @default.
• W2058317622 hasConcept C107824862 @default.
• W2058317622 hasConcept C143065580 @default.
• W2058317622 hasConcept C153911025 @default.
• W2058317622 hasConcept C156719811 @default.
• W2058317622 hasConcept C16318435 @default.
• W2058317622 hasConcept C164965036 @default.
• W2058317622 hasConcept C170748874 @default.
• W2058317622 hasConcept C178790620 @default.
• W2058317622 hasConcept C181199279 @default.
• W2058317622 hasConcept C185592680 @default.
• W2058317622 hasConcept C2756471 @default.
• W2058317622 hasConcept C2777501222 @default.
• W2058317622 hasConcept C41183919 @default.
• W2058317622 hasConcept C49105822 @default.
• W2058317622 hasConcept C54415193 @default.
• W2058317622 hasConcept C552990157 @default.
• W2058317622 hasConcept C55493867 @default.
• W2058317622 hasConcept C74884574 @default.
• W2058317622 hasConcept C82381507 @default.
• W2058317622 hasConcept C86803240 @default.
• W2058317622 hasConceptScore W2058317622C103408237 @default.
• W2058317622 hasConceptScore W2058317622C104317684 @default.
• W2058317622 hasConceptScore W2058317622C107824862 @default.
• W2058317622 hasConceptScore W2058317622C143065580 @default.
• W2058317622 hasConceptScore W2058317622C153911025 @default.
• W2058317622 hasConceptScore W2058317622C156719811 @default.
• W2058317622 hasConceptScore W2058317622C16318435 @default.
• W2058317622 hasConceptScore W2058317622C164965036 @default.
• W2058317622 hasConceptScore W2058317622C170748874 @default.
• W2058317622 hasConceptScore W2058317622C178790620 @default.
• W2058317622 hasConceptScore W2058317622C181199279 @default.
• W2058317622 hasConceptScore W2058317622C185592680 @default.
• W2058317622 hasConceptScore W2058317622C2756471 @default.
• W2058317622 hasConceptScore W2058317622C2777501222 @default.
• W2058317622 hasConceptScore W2058317622C41183919 @default.
• W2058317622 hasConceptScore W2058317622C49105822 @default.
• W2058317622 hasConceptScore W2058317622C54415193 @default.
• W2058317622 hasConceptScore W2058317622C552990157 @default.
• W2058317622 hasConceptScore W2058317622C55493867 @default.
• W2058317622 hasConceptScore W2058317622C74884574 @default.
• W2058317622 hasConceptScore W2058317622C82381507 @default.
• W2058317622 hasConceptScore W2058317622C86803240 @default.
• W2058317622 hasIssue "4849" @default.
• W2058317622 hasLocation W20583176221 @default.
• W2058317622 hasLocation W20583176222 @default.
• W2058317622 hasOpenAccess W2058317622 @default.
• W2058317622 hasPrimaryLocation W20583176221 @default.
• W2058317622 hasRelatedWork W1992930971 @default.

• next