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- W2058322612 abstract "Acute administration of the β-adrenergic agonist, isoproterenol (25–50μg/kg body weight, subcutaneous), induced drinking and an antidiuresis in rats during the first hour after treatment. Clonidine, administered at doses of 12·5 to 200μg/kg b.w., intraperitoneal, simultaneously with isoproterenol (25 μg/kg), attenuated the drink in a dose-dependent fashion. However, the antidiuresis induced by isoproterenol could be attenuated only by a very high dose of Clonidine (200μg/kgb.w.). When administered alone, Clonidine increased both urine and urinary sodium outputs in a dose-related fashion. Since Clonidine is reported to inhibit release of both antidiuretic hormone and renin, the increased urine output, increased urinary sodium excretion and reduction of the drinking response to isoproterenol are not unexpected findings. However, it appears likely that these effects may be secondary to its central a-adrenergic stimulatory action." @default.
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- W2058322612 date "1980-12-01" @default.
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- W2058322612 title "Antidipsogenic effect of clonidine on isoproterenol-induced water intake" @default.
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- W2058322612 doi "https://doi.org/10.1016/s0195-6663(80)80038-9" @default.
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