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• W2058324494 abstract "Superpotent and highly delta-opioid receptor selective cyclic peptides of the general formula H-Tyr-c[D-Pen-Gly-Phe(p-X)-Pen]-Phe-OH (where X = hydrogen or halogen) have been synthesized. In the binding assays the most selective and most potent compound is the p-bromophenyl-alanine-4 analogue (IC50 value = 0.19 nM, selectivity ratio = 21,000 for delta vs mu). In the GPI and MVD bioassays the most selective and most potent analogue is the p-fluoro-substituted analogue Tyr-[D-Pen-Gly-Phe(p-F)-Pen]-Phe-OH. In the MVD assay it has an exceptionally low IC50 value of 0.016 nM and a delta vs mu selectivity ratio of 45,000." @default.
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• W2058324494 date "1997-11-01" @default.
• W2058324494 modified "2023-10-03" @default.
• W2058324494 title "Cyclic Enkephalin Analogues with Exceptional Potency and Selectivity for δ-Opioid Receptors" @default.
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• W2058324494 doi "https://doi.org/10.1021/jm9704762" @default.
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