FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058324703> ?p ?o ?g. }

• W2058324703 endingPage "31" @default.
• W2058324703 startingPage "25" @default.
• W2058324703 abstract "Sickle cell anemia (SCA) is an autosomal-recessive hemoglobinopathy with a highly variable phenotype. Multiple clinical complications are characteristic of SCA including inflammatory and oxidant damage to both small and large blood vessels, hemolysis, vasoocclusion, and premature mortality. The overall severity of SCA is affected by multiple genetic modifier loci, including ARFGEF2, a gene known to modify TNF-α receptor release from human endothelial cells. In this report, we examine the effect of siRNA mediated knockdown of ARFGEF2 inhuman pulmonary artery endothelial cells and report that TNF-α induced expression of ICAM1 and VCAM1, both important mediators of endo-thelial-leukocyte adhesion, is significantly enhanced after ARFGEF2 knockdown. Levels of ICAM-1 protein are also increased in TNF-α treated endothelial cells after ARFGEF2 knockdown; the increased ICAM-1 appears to be localized in the cytoplasm. IL-1β stimulation of endothelial cells without ARFGEF2 produced enhanced ICAM1 expression only. Additionally, ARFGEF2 knockdown distinctly altered endothelial cell morphology. Large-vessel pathology in SCA is believed to begin with endothelial activation by inflammatory cytokines and adhesion of sickle erythrocytes and leukocytes, leading to a progressive vasculopathy characterized by smooth muscle cell migration and proliferation. Understanding how variability in the function of ARFGEF2 alters the response of pulmonary vasculature to TNF-α might suggest new targets for SCA treatment." @default.
• W2058324703 created "2016-06-24" @default.
• W2058324703 creator A5002394190 @default.
• W2058324703 creator A5014179169 @default.
• W2058324703 creator A5015657915 @default.
• W2058324703 creator A5026023901 @default.
• W2058324703 creator A5028481430 @default.
• W2058324703 creator A5029675993 @default.
• W2058324703 creator A5041227452 @default.
• W2058324703 creator A5049281779 @default.
• W2058324703 creator A5056483938 @default.
• W2058324703 creator A5068327377 @default.
• W2058324703 creator A5069732276 @default.
• W2058324703 date "2013-01-01" @default.
• W2058324703 modified "2023-10-16" @default.
• W2058324703 title "<i>ARFGEF2</i> Knockdown Enhances TNF-<i>α</i> Induced Endothelial Expression of the Cell Adhesion Molecules <i>VCAM1</i> and <i>ICAM1</i>" @default.
• W2058324703 cites W1971259974 @default.
• W2058324703 cites W1983732684 @default.
• W2058324703 cites W1990198259 @default.
• W2058324703 cites W2033048770 @default.
• W2058324703 cites W2035809865 @default.
• W2058324703 cites W2061571168 @default.
• W2058324703 cites W2063080769 @default.
• W2058324703 cites W2067434220 @default.
• W2058324703 cites W2070157035 @default.
• W2058324703 cites W2076539822 @default.
• W2058324703 cites W2078320770 @default.
• W2058324703 cites W2085961346 @default.
• W2058324703 cites W2094835614 @default.
• W2058324703 cites W2100454822 @default.
• W2058324703 cites W2102636422 @default.
• W2058324703 cites W2107277218 @default.
• W2058324703 cites W2125307800 @default.
• W2058324703 cites W2134232468 @default.
• W2058324703 cites W2142580711 @default.
• W2058324703 cites W2171937459 @default.
• W2058324703 cites W2418835073 @default.
• W2058324703 cites W25054622 @default.
• W2058324703 cites W2582743722 @default.
• W2058324703 doi "https://doi.org/10.4236/ojbd.2013.31006" @default.
• W2058324703 hasPublicationYear "2013" @default.
• W2058324703 type Work @default.
• W2058324703 sameAs 2058324703 @default.
• W2058324703 citedByCount "0" @default.
• W2058324703 crossrefType "journal-article" @default.
• W2058324703 hasAuthorship W2058324703A5002394190 @default.
• W2058324703 hasAuthorship W2058324703A5014179169 @default.
• W2058324703 hasAuthorship W2058324703A5015657915 @default.
• W2058324703 hasAuthorship W2058324703A5026023901 @default.
• W2058324703 hasAuthorship W2058324703A5028481430 @default.
• W2058324703 hasAuthorship W2058324703A5029675993 @default.
• W2058324703 hasAuthorship W2058324703A5041227452 @default.
• W2058324703 hasAuthorship W2058324703A5049281779 @default.
• W2058324703 hasAuthorship W2058324703A5056483938 @default.
• W2058324703 hasAuthorship W2058324703A5068327377 @default.
• W2058324703 hasAuthorship W2058324703A5069732276 @default.
• W2058324703 hasBestOaLocation W20583247031 @default.
• W2058324703 hasConcept C123012128 @default.
• W2058324703 hasConcept C134018914 @default.
• W2058324703 hasConcept C1491633281 @default.
• W2058324703 hasConcept C153911025 @default.
• W2058324703 hasConcept C16224149 @default.
• W2058324703 hasConcept C173396325 @default.
• W2058324703 hasConcept C17991360 @default.
• W2058324703 hasConcept C190283241 @default.
• W2058324703 hasConcept C202751555 @default.
• W2058324703 hasConcept C203014093 @default.
• W2058324703 hasConcept C2776992346 @default.
• W2058324703 hasConcept C2778620579 @default.
• W2058324703 hasConcept C502942594 @default.
• W2058324703 hasConcept C55493867 @default.
• W2058324703 hasConcept C85789140 @default.
• W2058324703 hasConcept C86803240 @default.
• W2058324703 hasConcept C95444343 @default.
• W2058324703 hasConceptScore W2058324703C123012128 @default.
• W2058324703 hasConceptScore W2058324703C134018914 @default.
• W2058324703 hasConceptScore W2058324703C1491633281 @default.
• W2058324703 hasConceptScore W2058324703C153911025 @default.
• W2058324703 hasConceptScore W2058324703C16224149 @default.
• W2058324703 hasConceptScore W2058324703C173396325 @default.
• W2058324703 hasConceptScore W2058324703C17991360 @default.
• W2058324703 hasConceptScore W2058324703C190283241 @default.
• W2058324703 hasConceptScore W2058324703C202751555 @default.
• W2058324703 hasConceptScore W2058324703C203014093 @default.
• W2058324703 hasConceptScore W2058324703C2776992346 @default.
• W2058324703 hasConceptScore W2058324703C2778620579 @default.
• W2058324703 hasConceptScore W2058324703C502942594 @default.
• W2058324703 hasConceptScore W2058324703C55493867 @default.
• W2058324703 hasConceptScore W2058324703C85789140 @default.
• W2058324703 hasConceptScore W2058324703C86803240 @default.
• W2058324703 hasConceptScore W2058324703C95444343 @default.
• W2058324703 hasIssue "01" @default.
• W2058324703 hasLocation W20583247031 @default.
• W2058324703 hasOpenAccess W2058324703 @default.
• W2058324703 hasPrimaryLocation W20583247031 @default.
• W2058324703 hasRelatedWork W161989133 @default.
• W2058324703 hasRelatedWork W2066215373 @default.
• W2058324703 hasRelatedWork W2110566645 @default.

• next