Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058329306> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2058329306 endingPage "676" @default.
- W2058329306 startingPage "668" @default.
- W2058329306 abstract "The current study was designed to investigate the mechanisms by which ropivacaine may act within the central nervous system (CNS) to produce cardiotoxicity. Eighty New Zealand rabbits were divided into four groups randomly. In Group 1, 20 rabbits received intracerebroventricular (icv) saline, and then received icv ropivacaine 30 min later. In Group 2, 20 rabbits received icv ropivacaine. Whenever dysrhythmias continued for more than 5 min, 0.1 ml saline was administered into the left cerebral ventricle. Ten minutes later, 0.1 ml midazolam was given into the left lateral ventricle. In Group 3, 20 rabbits received icv ropivacaine, and once the dysrhythmias developed, the inspired isoflurane concentration was increased from 0.75% to 1.50%. In Group 4, 20 animals received an intravenous (iv) phenylephrine infusion until dysrhythmias occurred. In Group 1, the rabbits did not develop dysrhythmias in response to icv saline, whereas dysrhythmias did develop in these animals after icv ropivacaine. In Group 2, icv saline had no effect on the dysrhythmias; however, icv midazolam terminated cardiac dysrhythmias. In Group 3, an increase in the concentration of the inspired isoflurane had no effect on dysrhythmias. In Group 4, icv midazolam had no effect on dysrhythmias in response to iv phenylephrine. Ropivacaine administered directly into the CNS is capable of producing cardiac dysrhythmias; midazolam terminated dysrhythmias presumably by potentiation of γ-aminobutyric acid (GABA) receptor activity. Our results suggest that ropivacaine produces some of its cardiotoxicity not only by the direct cardiotoxicity of the drug, but also by the CNS effects of ropivacaine." @default.
- W2058329306 created "2016-06-24" @default.
- W2058329306 creator A5000319584 @default.
- W2058329306 creator A5008296177 @default.
- W2058329306 creator A5046719780 @default.
- W2058329306 creator A5080293953 @default.
- W2058329306 creator A5086179952 @default.
- W2058329306 date "2011-07-30" @default.
- W2058329306 modified "2023-10-12" @default.
- W2058329306 title "Midazolam in rabbits terminates dysrhythmias caused by intracerebroventricular ropivacaine" @default.
- W2058329306 cites W134801640 @default.
- W2058329306 cites W1535851851 @default.
- W2058329306 cites W1822712143 @default.
- W2058329306 cites W1964895428 @default.
- W2058329306 cites W1978779477 @default.
- W2058329306 cites W1988876210 @default.
- W2058329306 cites W2016554793 @default.
- W2058329306 cites W2019463017 @default.
- W2058329306 cites W2022029920 @default.
- W2058329306 cites W2032810616 @default.
- W2058329306 cites W2037862343 @default.
- W2058329306 cites W2043973898 @default.
- W2058329306 cites W2057623315 @default.
- W2058329306 cites W2081270212 @default.
- W2058329306 cites W2085957406 @default.
- W2058329306 cites W2089076340 @default.
- W2058329306 cites W2089914077 @default.
- W2058329306 cites W2114860965 @default.
- W2058329306 cites W2171609174 @default.
- W2058329306 cites W2327490142 @default.
- W2058329306 cites W2615254853 @default.
- W2058329306 cites W4238257276 @default.
- W2058329306 cites W1988891426 @default.
- W2058329306 doi "https://doi.org/10.1631/jzus.b1000337" @default.
- W2058329306 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3150721" @default.
- W2058329306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21796808" @default.
- W2058329306 hasPublicationYear "2011" @default.
- W2058329306 type Work @default.
- W2058329306 sameAs 2058329306 @default.
- W2058329306 citedByCount "1" @default.
- W2058329306 countsByYear W20583293062023 @default.
- W2058329306 crossrefType "journal-article" @default.
- W2058329306 hasAuthorship W2058329306A5000319584 @default.
- W2058329306 hasAuthorship W2058329306A5008296177 @default.
- W2058329306 hasAuthorship W2058329306A5046719780 @default.
- W2058329306 hasAuthorship W2058329306A5080293953 @default.
- W2058329306 hasAuthorship W2058329306A5086179952 @default.
- W2058329306 hasBestOaLocation W20583293062 @default.
- W2058329306 hasConcept C126322002 @default.
- W2058329306 hasConcept C2776359302 @default.
- W2058329306 hasConcept C2776814716 @default.
- W2058329306 hasConcept C2777397205 @default.
- W2058329306 hasConcept C2777952589 @default.
- W2058329306 hasConcept C2778000748 @default.
- W2058329306 hasConcept C2778233292 @default.
- W2058329306 hasConcept C2778921608 @default.
- W2058329306 hasConcept C2780269707 @default.
- W2058329306 hasConcept C29730261 @default.
- W2058329306 hasConcept C42219234 @default.
- W2058329306 hasConcept C71924100 @default.
- W2058329306 hasConcept C84393581 @default.
- W2058329306 hasConceptScore W2058329306C126322002 @default.
- W2058329306 hasConceptScore W2058329306C2776359302 @default.
- W2058329306 hasConceptScore W2058329306C2776814716 @default.
- W2058329306 hasConceptScore W2058329306C2777397205 @default.
- W2058329306 hasConceptScore W2058329306C2777952589 @default.
- W2058329306 hasConceptScore W2058329306C2778000748 @default.
- W2058329306 hasConceptScore W2058329306C2778233292 @default.
- W2058329306 hasConceptScore W2058329306C2778921608 @default.
- W2058329306 hasConceptScore W2058329306C2780269707 @default.
- W2058329306 hasConceptScore W2058329306C29730261 @default.
- W2058329306 hasConceptScore W2058329306C42219234 @default.
- W2058329306 hasConceptScore W2058329306C71924100 @default.
- W2058329306 hasConceptScore W2058329306C84393581 @default.
- W2058329306 hasIssue "8" @default.
- W2058329306 hasLocation W20583293061 @default.
- W2058329306 hasLocation W20583293062 @default.
- W2058329306 hasLocation W20583293063 @default.
- W2058329306 hasLocation W20583293064 @default.
- W2058329306 hasOpenAccess W2058329306 @default.
- W2058329306 hasPrimaryLocation W20583293061 @default.
- W2058329306 hasRelatedWork W1570678305 @default.
- W2058329306 hasRelatedWork W2058329306 @default.
- W2058329306 hasRelatedWork W2067821596 @default.
- W2058329306 hasRelatedWork W2114898508 @default.
- W2058329306 hasRelatedWork W2154185373 @default.
- W2058329306 hasRelatedWork W2348120266 @default.
- W2058329306 hasRelatedWork W2351629881 @default.
- W2058329306 hasRelatedWork W2356390456 @default.
- W2058329306 hasRelatedWork W3047994247 @default.
- W2058329306 hasRelatedWork W3146987347 @default.
- W2058329306 hasVolume "12" @default.
- W2058329306 isParatext "false" @default.
- W2058329306 isRetracted "false" @default.
- W2058329306 magId "2058329306" @default.
- W2058329306 workType "article" @default.