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• W2058332937 abstract "No AccessJournal of UrologyInvestigative urology1 Feb 2007Endothelium Dependent Relaxation in Rabbit Genital Resistance Arteries is Predominantly Mediated by Endothelial-Derived Hyperpolarizing Factor in Females and Nitric Oxide in Malesis companion ofCirculating Monocyte Oxidative Activity is Increased in Patients With Type 2 Diabetes and Erectile Dysfunction J.S. Morton, V.M. Jackson, C.J. Daly, and J.C. McGrath J.S. MortonJ.S. Morton More articles by this author , V.M. JacksonV.M. Jackson More articles by this author , C.J. DalyC.J. Daly More articles by this author , and J.C. McGrathJ.C. McGrath More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2006.09.072AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: In nongenital arteries a sex difference has been postulated in the dominant endothelium-derived relaxant factor(s), eg nitric oxide, prostacyclin or endothelial-derived hyperpolarizing factor. Knowledge of endothelium-derived relaxant factor mechanisms in genital tissues could influence the development of novel treatments for sexual dysfunction. We compared nitric oxide and endothelial-derived hyperpolarizing factor contributions to acetylcholine induced relaxation in the genital arteries of the 2 sexes. Materials and Methods: Male dorsal and cavernous penile arteries, and female extravaginal and intravaginal arteries from New Zealand White rabbits were studied. Acetylcholine concentration-vasodilator response curves were constructed in the presence of the nitric oxide synthase inhibitor Nω-nitro-L-arginine methyl ester, K+ channel blockers (apamin and charybdotoxin) or a combination. Indomethacin was present throughout to exclude prostacyclins. Results: Extravaginal artery relaxation was predominantly endothelial-derived hyperpolarizing factor induced. Apamin plus charybdotoxin decreased maximal relaxations from a mean ± SEM of 77% ± 4% to 23% ± 3% in 6 preparations (p <0.01). However, nitric oxide and endothelial-derived hyperpolarizing factor contributed to overall function. Dorsal artery relaxation was largely nitric oxide induced. Nω-nitro-L-arginine methyl ester decreased maximal relaxations from 90% ± 3% to 41% ± 9% (p <0.001) with no endothelial-derived hyperpolarizing factor involvement (p >0.05). In cavernous and intravaginal arteries nitric oxide and endothelial-derived hyperpolarizing factor contributed to acetylcholine induced relaxation, while nitric oxide predominated. Blocking nitric oxide synthase or K+ channels indicated that myogenic tone and constitutive activity of endothelium-derived relaxant factors were present. Vasodilator nerve mediated responses were influenced by each with the former more effective. Conclusions: Vaginal inflow arteries showed a dominance of endothelial-derived hyperpolarizing factor, contrasting with nitric oxide in penile arteries. Penile arteries followed the trend that endothelial-derived hyperpolarizing factor involvement increased with decreasing vessel caliber, while the reverse was demonstrated in female arteries. References 1 : Physiology of penile erection. Physiol Rev1995; 75: 191. Crossref, Medline, Google Scholar 2 : Nitric oxide in the penis: physiology and pathology. J Urol1997; 157: 320. 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Crossref, Medline, Google Scholar 8 : Prostacyclin synthesis by the corpora cavernosa of the human penis: evidence for muscarinic control and pathological implications. Prostaglandins Leukot Med1986; 23: 211. Google Scholar 9 : Calcium dobesilate potentiates endothelium-derived hyperpolarizing factor-mediated relaxation of human penile resistance arteries. Br J Pharmacol2003; 139: 854. Google Scholar 10 : Endothelial potassium channels, endothelium-dependent hyperpolarisation and the regulation of vascular tone in health and disease. Clin Exp Pharmacol Physiol2004; 31: 641. Google Scholar 11 : Factors, fiction and endothelium-derived hyperpolarising factor. Clin Exp Pharmacol Physiol2004; 31: 563. Google Scholar 12 : Effects of NG-substituted analogues of L-arginine on NANC relaxation of the rat annococcygeus and bovine retractor penis muscles and the bovine penile artery. Br J Pharmacol1991; 104: 53. Google Scholar 13 : Nitric oxide is involved in the inhibitory neurotransmission and endothelium-dependent relaxations of human small penile arteries. Clin Sci (London)1997; 92: 269. Google Scholar 14 : Sex differences in the relative contributions of nitric oxide and EDHF to agonist-stimulated endothelium-dependent relaxations in the rat isolated mesenteric arterial bed. Br J Pharmacol1998; 123: 1700. Google Scholar 15 : Male-female differences in the relative contribution of endothelial vasodilators released by rat tail artery. Life Sci2002; 71: 1633. Google Scholar 16 : The effect of nitric oxide on the production of prostaglandin E2 by hydroxyapatite-stimulated a human osteoblast (HOS) cell line. Biomed Pharmacother2006; 60: 147. Google Scholar 17 : Decreased endothelium-dependent hyperpolarisation to acetylcholine in smooth muscle of the mesenteric artery of spontaneously hypertensive rats. Circ Res1992; 70: 660. Google Scholar 18 : Alterations in endothelium-dependent hyperpolarisation and relaxation in mesenteric arteries from streptozotocin-induced diabetic rats. Br J Pharmacol1997; 121: 1383. Google Scholar 19 : A Colour Atlas of Anatomy of Small Laboratory Animals. London: Wolfe Publishing1990. Google Scholar 20 : Principles of Anatomy and Physiology. New York: John Wiley and Sons2000. Google Scholar University of Glasgow, Glasgow and Pfizer Global Research and Development (CJD), Sandwich, United Kingdom© 2007 by American Urological AssociationFiguresReferencesRelatedDetailsRelated articlesJournal of Urology9 Nov 2018Circulating Monocyte Oxidative Activity is Increased in Patients With Type 2 Diabetes and Erectile Dysfunction Volume 177Issue 2February 2007Page: 786-791 Advertisement Copyright & Permissions© 2007 by American Urological AssociationKeywordsvaginarabbitsnitric oxidepenisarteriesMetricsAuthor Information J.S. Morton More articles by this author V.M. Jackson More articles by this author C.J. Daly More articles by this author J.C. McGrath More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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