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• W2058334019 endingPage "34" @default.
• W2058334019 startingPage "28" @default.
• W2058334019 abstract "Skin concentrations of topically administered compounds need to be considered in order to evaluate their efficacies and toxicities. This study investigated the relationship between the skin permeation and concentrations of compounds, and also predicted the skin concentrations of these compounds using their permeation parameters. Full-thickness skin or stripped skin from pig ears was set on a vertical-type diffusion cell, and lidocaine (LID) solution was applied to the stratum corneum (SC) in order to determine in vitro skin permeability. Permeation parameters were obtained based on Fick's second law of diffusion. LID concentrations at each depth of the SC were measured using tape-stripping. Concentration-depth profiles were obtained from viable epidermis and dermis (VED) by analyzing horizontal sections. The corresponding skin concentration at each depth was calculated based on Fick's law using permeation parameters and then compared with the observed value. The steady state LID concentrations decreased linearly as the site became deeper in SC or VED. The calculated concentration-depth profiles of the SC and VED were almost identical to the observed profiles. The compound concentration at each depth could be easily predicted in the skin using diffusion equations and skin permeation data. Thus, this method was considered to be useful for promoting the efficient preparation of topically applied drugs and cosmetics." @default.
• W2058334019 created "2016-06-24" @default.
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• W2058334019 date "1976-01-01" @default.
• W2058334019 modified "2023-10-14" @default.
• W2058334019 title "Association between clinical cardiac status, laboratory parameters, and digoxin usage" @default.
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• W2058334019 doi "https://doi.org/10.1016/s0002-8703(76)80431-0" @default.
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