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- W2058339964 abstract "Objective: Intramuscular(IM) Benzodiazepines and/or Haloperidol alone or with benzodiazepines arefrequently used to treat agitation. Based on emerging literature regardingQuetiapine used for the control of anxiety we examined Quetiapine as a possiblealternative in selected cases. Methods: This study was a single-blindrandomized study comparing Quetiapine PO (300 mg) with a combination ofHaloperidol (5 mg), Benztropine mesylate (2 mg) and lorazepam (2 mg) administeredIM to treat agitated patients seeking care in a busy psychiatric emergencysetting. Male or female patients (18 - 60), deemed by the attending (admitting)psychiatrist to be indicative of agitated and/or aggressive behavior and had aPositive and Negative Syndrome Score-Excited Component (PANSS-EC), as evaluatedby the Research Psychiatrist, and total score equal to or greater than 15.Patients deemed competent were randomized into one of the following treatmentgroups: Quetiapine 300 or Haloperidol 5 mg, benztropine mesylate, or lorazepamgiven by the IM route. Two scales, PANSS-EC and CGI-C were used to assess patientsin the trial. The primary outcome measure PANSS-EC at 2 hours afteradministration of the medication. Results: Sixty-eight patients were includedin the study. There were no significant treatment group differences in baselinecondition. There was no significant difference between the two conditions.There was, however, a significant within-group decrease from baselinecondition. Conclusion: Finding no significant differences suggests that ingeneral the two treatments were equivalent. To sum up, Quetiapine 300 mg as asingle dose appeared safe and effective in agitated patients treated in an ER.The results were similar to a comparison group receiving an intra-muscularcombination of Haloperidol, Lorazepam and Benztropine. This study hassignificant limitations. The study was single blind and the use of a placebowould have strengthened the design but would be considered unethical. Thesample size was relatively small and the group of patients who come to the ERmay not be representative of the population of patients who visit across thecountry. And finally it was a select subgroup who made up the study populationand who were probably less severely ill than other subjects who came to our ER." @default.
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- W2058339964 date "2014-01-01" @default.
- W2058339964 modified "2023-09-25" @default.
- W2058339964 title "A Comparison Study of the Efficacy of Rapid Titration Quetiapine and Haloperidol in Agitated Adults in an Emergency Setting" @default.
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- W2058339964 doi "https://doi.org/10.4236/ojpsych.2014.43025" @default.
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