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- W2058344625 abstract "<h3>Background</h3> Obese patients with type two diabetes mellitus (T2DM) may have a better prognosis than patients of normal weight, but reports are limited by study size, duration and confounders. <h3>Methods</h3> We investigated the relationship between body mass index (BMI) and prognosis in 10,568 patients with T2DM without known CV disease followed for a median of 10.6 (IQR: 7.8–13.4) years. Hospital admissions for acute coronary syndrome (ACS), cerebrovascular accidents (CVA) and heart failure (HF) and all-cause mortality were recorded. Information on comorbidity (cancer, lung diseases and chronic renal failure) was also collected as confounder. <h3>Results</h3> Median age was 63 ± 19 years, 54% were men and median BMI was 28.8 (IQR: 25.2–32.4 kg.m<sup>2</sup>). Adjusting for differences in age and other variables, patients in the highest quartile of BMI had the greatest risk of hospitalisation for ACS or HF (HRs with 95% CI for highest versus lowest quartile were 1.39 1.14–1.70; p = 0.001 and 1.36 1.08–1.71; p = 0.01 respectively) but the risk of CVA was similar amongst BMI quartiles. However, patients in higher BMI quartiles had lower mortality rates, with the nadir of risk at BMI 25–30 kg/m<sup>2</sup> (adjusted for confounders). Greater BMI was associated with lower mortality especially amongst older patients. <h3>Conclusions</h3> Patients with T2DM and moderately increased BMI, in the overweight range of 25–30 kg/m<sup>2</sup>, have a lower mortality than slimmer patients. Amongst older patients, even higher BMI may be associated with lower risk. However, obesity is associated with an increased risk of hospitalisation for cardiovascular events." @default.
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- W2058344625 date "2014-05-31" @default.
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- W2058344625 title "116 The Obesity Paradox in Type II Diabetes Mellitus. Impact of Body Mass Index on Prognosis" @default.
- W2058344625 doi "https://doi.org/10.1136/heartjnl-2014-306118.116" @default.
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