Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058348515> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2058348515 endingPage "203" @default.
- W2058348515 startingPage "193" @default.
- W2058348515 abstract "Fertilization of the mammalian egg initiates transient and repetitive release of Ca2+ from intracellular stores. The mechanism by which these Ca2+ transients are produced is not completely known. We examined the role of two principal Ca2+ release mechanisms, inositol trisphosphate-induced Ca2+ release and Ca2+-induced Ca2+ release, in altering intracellular Ca2+ in the mouse egg. Microinjection of inositol 1,4,5-trisphosphate (IP3) transiently elevated intracellular Ca2+ and, at higher concentrations, produced repetitive Ca2+ transients. Addition of 100 μM thimerosal, a sulfhydryl reagent, caused repetitive Ca2+ transients. IP3 and thimerosal responses were inhibited by prior injection of heparin, a competitive antagonist of IP3-induced Ca2+ release. Addition of caffeine or injection of caffeine, ryanodine, or cyclic ADP-ribose, which are known to initiate or modulate Ca2+-induced Ca2+ release in sea urchin eggs and other cells, produced no change in intracellular Ca2+. The response to injection of Ca2+ was not altered by prior injection of ryanodine. The magnitude of the Ca2+ transients produced by injection of IP3 was not changed by prior injection of cyclic ADP-ribose or external caffeine. We found no evidence of Ca2+-induced Ca2+ release from ryanodine- or caffeine-sensitive stores. It is most likely that release of Ca2+ from intracellular stores in the mouse egg is dependent on IP3-induced Ca2+ release." @default.
- W2058348515 created "2016-06-24" @default.
- W2058348515 creator A5083411780 @default.
- W2058348515 creator A5085634723 @default.
- W2058348515 date "1994-01-01" @default.
- W2058348515 modified "2023-10-16" @default.
- W2058348515 title "Regulation of Intracellular Calcium in the Mouse Egg: Evidence for Inositol Trisphosphate-Induced Calcium Release, but not Calcium-Induced Calcium Release1" @default.
- W2058348515 doi "https://doi.org/10.1095/biolreprod50.1.193" @default.
- W2058348515 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8312443" @default.
- W2058348515 hasPublicationYear "1994" @default.
- W2058348515 type Work @default.
- W2058348515 sameAs 2058348515 @default.
- W2058348515 citedByCount "115" @default.
- W2058348515 countsByYear W20583485152012 @default.
- W2058348515 countsByYear W20583485152013 @default.
- W2058348515 countsByYear W20583485152015 @default.
- W2058348515 countsByYear W20583485152016 @default.
- W2058348515 countsByYear W20583485152017 @default.
- W2058348515 countsByYear W20583485152018 @default.
- W2058348515 countsByYear W20583485152019 @default.
- W2058348515 countsByYear W20583485152020 @default.
- W2058348515 countsByYear W20583485152021 @default.
- W2058348515 countsByYear W20583485152022 @default.
- W2058348515 countsByYear W20583485152023 @default.
- W2058348515 crossrefType "journal-article" @default.
- W2058348515 hasAuthorship W2058348515A5083411780 @default.
- W2058348515 hasAuthorship W2058348515A5085634723 @default.
- W2058348515 hasBestOaLocation W20583485151 @default.
- W2058348515 hasConcept C10205521 @default.
- W2058348515 hasConcept C113217602 @default.
- W2058348515 hasConcept C12554922 @default.
- W2058348515 hasConcept C126322002 @default.
- W2058348515 hasConcept C134018914 @default.
- W2058348515 hasConcept C152624196 @default.
- W2058348515 hasConcept C159912055 @default.
- W2058348515 hasConcept C170493617 @default.
- W2058348515 hasConcept C181080969 @default.
- W2058348515 hasConcept C2777336126 @default.
- W2058348515 hasConcept C2777427919 @default.
- W2058348515 hasConcept C2778500429 @default.
- W2058348515 hasConcept C2781387506 @default.
- W2058348515 hasConcept C28328180 @default.
- W2058348515 hasConcept C519063684 @default.
- W2058348515 hasConcept C55493867 @default.
- W2058348515 hasConcept C62525196 @default.
- W2058348515 hasConcept C71924100 @default.
- W2058348515 hasConcept C79879829 @default.
- W2058348515 hasConcept C86803240 @default.
- W2058348515 hasConcept C95444343 @default.
- W2058348515 hasConceptScore W2058348515C10205521 @default.
- W2058348515 hasConceptScore W2058348515C113217602 @default.
- W2058348515 hasConceptScore W2058348515C12554922 @default.
- W2058348515 hasConceptScore W2058348515C126322002 @default.
- W2058348515 hasConceptScore W2058348515C134018914 @default.
- W2058348515 hasConceptScore W2058348515C152624196 @default.
- W2058348515 hasConceptScore W2058348515C159912055 @default.
- W2058348515 hasConceptScore W2058348515C170493617 @default.
- W2058348515 hasConceptScore W2058348515C181080969 @default.
- W2058348515 hasConceptScore W2058348515C2777336126 @default.
- W2058348515 hasConceptScore W2058348515C2777427919 @default.
- W2058348515 hasConceptScore W2058348515C2778500429 @default.
- W2058348515 hasConceptScore W2058348515C2781387506 @default.
- W2058348515 hasConceptScore W2058348515C28328180 @default.
- W2058348515 hasConceptScore W2058348515C519063684 @default.
- W2058348515 hasConceptScore W2058348515C55493867 @default.
- W2058348515 hasConceptScore W2058348515C62525196 @default.
- W2058348515 hasConceptScore W2058348515C71924100 @default.
- W2058348515 hasConceptScore W2058348515C79879829 @default.
- W2058348515 hasConceptScore W2058348515C86803240 @default.
- W2058348515 hasConceptScore W2058348515C95444343 @default.
- W2058348515 hasIssue "1" @default.
- W2058348515 hasLocation W20583485151 @default.
- W2058348515 hasLocation W20583485152 @default.
- W2058348515 hasOpenAccess W2058348515 @default.
- W2058348515 hasPrimaryLocation W20583485151 @default.
- W2058348515 hasRelatedWork W132187563 @default.
- W2058348515 hasRelatedWork W1658019904 @default.
- W2058348515 hasRelatedWork W1889796806 @default.
- W2058348515 hasRelatedWork W1966993129 @default.
- W2058348515 hasRelatedWork W2018200055 @default.
- W2058348515 hasRelatedWork W2093144498 @default.
- W2058348515 hasRelatedWork W2164715751 @default.
- W2058348515 hasRelatedWork W2168839532 @default.
- W2058348515 hasRelatedWork W2186033591 @default.
- W2058348515 hasRelatedWork W2368371456 @default.
- W2058348515 hasVolume "50" @default.
- W2058348515 isParatext "false" @default.
- W2058348515 isRetracted "false" @default.
- W2058348515 magId "2058348515" @default.
- W2058348515 workType "article" @default.