Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058351861> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2058351861 endingPage "159" @default.
- W2058351861 startingPage "154" @default.
- W2058351861 abstract "A study was performed to investigate the local penetration into the nail, the systemic absorption into the rest of the body, and the routes of excretion of sodium pyrithione following topical application to the nail. Approximately 20 microliters of a film-forming 3% sodium 14C-pyrithione solution was applied once daily to 5 fingernails and 5 toenails of 4 rhesus monkeys for 6 or 7 days. Following dose removal on study day 7, 2 animals were sacrificed, and the treated nails were analyzed for radioactivity. The other 2 monkeys received the topical dose for 1 more day and were monitored during the postdosing period. Sodium 14C-pyrithione was absorbed slowly into and across the nail following topical application, with the nails serving as reservoirs for the drug. Further evidence of the slow movement of sodium pyrithione across the nail was provided by peak plasma 14C equivalents obtained on day 9, 1 day after the last dose had been removed from the nails. Only slight drug concentrations were measurable in plasma, with no radioactivity observed beyond day 12. The urinary excretion data exhibited a delay in peak urinary excretion (days 8 and 9), and an elimination half-life of 2 days, so that approximately 90% of the absorbed drug was eliminated within 1 week following treatment. Including a minor excretion pathway through the feces, total excretion as a percent of dosage was 8.5%, indicating that less than 10% of the applied topical dose of sodium pyrithione was absorbed systemically.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2058351861 created "2016-06-24" @default.
- W2058351861 creator A5009104393 @default.
- W2058351861 creator A5023442466 @default.
- W2058351861 creator A5070962881 @default.
- W2058351861 creator A5085910861 @default.
- W2058351861 creator A5087522094 @default.
- W2058351861 date "1992-01-01" @default.
- W2058351861 modified "2023-10-16" @default.
- W2058351861 title "Topical and Systemic Absorption of Sodium Pyrithione following Topical Application to the Nails of the Rhesus Monkey" @default.
- W2058351861 doi "https://doi.org/10.1159/000211032" @default.
- W2058351861 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1445705" @default.
- W2058351861 hasPublicationYear "1992" @default.
- W2058351861 type Work @default.
- W2058351861 sameAs 2058351861 @default.
- W2058351861 citedByCount "7" @default.
- W2058351861 countsByYear W20583518612012 @default.
- W2058351861 countsByYear W20583518612018 @default.
- W2058351861 crossrefType "journal-article" @default.
- W2058351861 hasAuthorship W2058351861A5009104393 @default.
- W2058351861 hasAuthorship W2058351861A5023442466 @default.
- W2058351861 hasAuthorship W2058351861A5070962881 @default.
- W2058351861 hasAuthorship W2058351861A5085910861 @default.
- W2058351861 hasAuthorship W2058351861A5087522094 @default.
- W2058351861 hasConcept C10146269 @default.
- W2058351861 hasConcept C112705442 @default.
- W2058351861 hasConcept C121332964 @default.
- W2058351861 hasConcept C125287762 @default.
- W2058351861 hasConcept C126322002 @default.
- W2058351861 hasConcept C127413603 @default.
- W2058351861 hasConcept C134018914 @default.
- W2058351861 hasConcept C178790620 @default.
- W2058351861 hasConcept C185592680 @default.
- W2058351861 hasConcept C24890656 @default.
- W2058351861 hasConcept C2780026642 @default.
- W2058351861 hasConcept C42475967 @default.
- W2058351861 hasConcept C537181965 @default.
- W2058351861 hasConcept C55493867 @default.
- W2058351861 hasConcept C71924100 @default.
- W2058351861 hasConcept C80107235 @default.
- W2058351861 hasConcept C98274493 @default.
- W2058351861 hasConceptScore W2058351861C10146269 @default.
- W2058351861 hasConceptScore W2058351861C112705442 @default.
- W2058351861 hasConceptScore W2058351861C121332964 @default.
- W2058351861 hasConceptScore W2058351861C125287762 @default.
- W2058351861 hasConceptScore W2058351861C126322002 @default.
- W2058351861 hasConceptScore W2058351861C127413603 @default.
- W2058351861 hasConceptScore W2058351861C134018914 @default.
- W2058351861 hasConceptScore W2058351861C178790620 @default.
- W2058351861 hasConceptScore W2058351861C185592680 @default.
- W2058351861 hasConceptScore W2058351861C24890656 @default.
- W2058351861 hasConceptScore W2058351861C2780026642 @default.
- W2058351861 hasConceptScore W2058351861C42475967 @default.
- W2058351861 hasConceptScore W2058351861C537181965 @default.
- W2058351861 hasConceptScore W2058351861C55493867 @default.
- W2058351861 hasConceptScore W2058351861C71924100 @default.
- W2058351861 hasConceptScore W2058351861C80107235 @default.
- W2058351861 hasConceptScore W2058351861C98274493 @default.
- W2058351861 hasIssue "3" @default.
- W2058351861 hasLocation W20583518611 @default.
- W2058351861 hasLocation W20583518612 @default.
- W2058351861 hasOpenAccess W2058351861 @default.
- W2058351861 hasPrimaryLocation W20583518611 @default.
- W2058351861 hasRelatedWork W1978634877 @default.
- W2058351861 hasRelatedWork W1984705561 @default.
- W2058351861 hasRelatedWork W2006202112 @default.
- W2058351861 hasRelatedWork W2021846613 @default.
- W2058351861 hasRelatedWork W2028993205 @default.
- W2058351861 hasRelatedWork W2154101925 @default.
- W2058351861 hasRelatedWork W2378109603 @default.
- W2058351861 hasRelatedWork W2413511363 @default.
- W2058351861 hasRelatedWork W297699154 @default.
- W2058351861 hasRelatedWork W4240148004 @default.
- W2058351861 hasVolume "5" @default.
- W2058351861 isParatext "false" @default.
- W2058351861 isRetracted "false" @default.
- W2058351861 magId "2058351861" @default.
- W2058351861 workType "article" @default.