Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058352016> ?p ?o ?g. }
Showing items 1 to 69 of
69
with 100 items per page.
- W2058352016 endingPage "S163" @default.
- W2058352016 startingPage "S163" @default.
- W2058352016 abstract "A rapid and sensitive bioassay based on liquid chromatography–tandem mass spectrometry (LC–MS/MS) has been developed and validated for the simultaneous determination of codeine and its active metabolites, including morphine, morphine 3β-glucuronide (M3G) and morphine 6β-glucuronide (M6G), in human plasma. Sample preparation of plasma after the addition of naloxone as internal standard (IS) involved solid-phase extraction (SPE) on C18 cartridges. Reversed-phase chromatography using a gradient elution with methanol and 0.04% formic acid solution (pH 3.5) was used for separation in a run time of 5 min. The analytes were detected in the positive ion mode using multiple reaction monitoring (MRM) of the transitions at m/z 300.4 → 215.2 for codeine, 286.2 → 152.0 for morphine, and 462.2 → 286.2 for M3G and M6G. The method has the following performance characteristics: a reliable response range of 0.05–80 ng/ml for codeine, M3G and M6G and a response range of 0.05–5.0 ng/ml for morphine with correlation coefficients (r) of >0.997 for all analytes. The lower limit of quantitation (LLOQ) for all four analytes was 0.05 ng/ml. The intra- and inter-day precision and accuracy of the quality control samples at low, medium and high concentration levels showed <12% relative standard deviation (RSD) and −6.9 to 8.1% relative error (RE) for all the analytes. The method was successfully applied to a pharmacokinetic study of codeine in healthy Mongolian Chinese volunteers after a 30 mg oral dose." @default.
- W2058352016 created "2016-06-24" @default.
- W2058352016 creator A5020331749 @default.
- W2058352016 creator A5027921942 @default.
- W2058352016 creator A5071883233 @default.
- W2058352016 date "2008-10-01" @default.
- W2058352016 modified "2023-09-27" @default.
- W2058352016 title "Opiates determination in humour vitreous and urine by immnunochromatgraphic test and GC/MS method" @default.
- W2058352016 doi "https://doi.org/10.1016/j.toxlet.2008.06.322" @default.
- W2058352016 hasPublicationYear "2008" @default.
- W2058352016 type Work @default.
- W2058352016 sameAs 2058352016 @default.
- W2058352016 citedByCount "3" @default.
- W2058352016 countsByYear W20583520162015 @default.
- W2058352016 countsByYear W20583520162017 @default.
- W2058352016 crossrefType "journal-article" @default.
- W2058352016 hasAuthorship W2058352016A5020331749 @default.
- W2058352016 hasAuthorship W2058352016A5027921942 @default.
- W2058352016 hasAuthorship W2058352016A5071883233 @default.
- W2058352016 hasConcept C10390740 @default.
- W2058352016 hasConcept C119128265 @default.
- W2058352016 hasConcept C162356407 @default.
- W2058352016 hasConcept C185592680 @default.
- W2058352016 hasConcept C2777379063 @default.
- W2058352016 hasConcept C2777389121 @default.
- W2058352016 hasConcept C2777866328 @default.
- W2058352016 hasConcept C2780026642 @default.
- W2058352016 hasConcept C43617362 @default.
- W2058352016 hasConcept C4725764 @default.
- W2058352016 hasConcept C55493867 @default.
- W2058352016 hasConcept C64489805 @default.
- W2058352016 hasConcept C71924100 @default.
- W2058352016 hasConcept C81426234 @default.
- W2058352016 hasConcept C98274493 @default.
- W2058352016 hasConceptScore W2058352016C10390740 @default.
- W2058352016 hasConceptScore W2058352016C119128265 @default.
- W2058352016 hasConceptScore W2058352016C162356407 @default.
- W2058352016 hasConceptScore W2058352016C185592680 @default.
- W2058352016 hasConceptScore W2058352016C2777379063 @default.
- W2058352016 hasConceptScore W2058352016C2777389121 @default.
- W2058352016 hasConceptScore W2058352016C2777866328 @default.
- W2058352016 hasConceptScore W2058352016C2780026642 @default.
- W2058352016 hasConceptScore W2058352016C43617362 @default.
- W2058352016 hasConceptScore W2058352016C4725764 @default.
- W2058352016 hasConceptScore W2058352016C55493867 @default.
- W2058352016 hasConceptScore W2058352016C64489805 @default.
- W2058352016 hasConceptScore W2058352016C71924100 @default.
- W2058352016 hasConceptScore W2058352016C81426234 @default.
- W2058352016 hasConceptScore W2058352016C98274493 @default.
- W2058352016 hasLocation W20583520161 @default.
- W2058352016 hasOpenAccess W2058352016 @default.
- W2058352016 hasPrimaryLocation W20583520161 @default.
- W2058352016 hasRelatedWork W1571289809 @default.
- W2058352016 hasRelatedWork W1993986875 @default.
- W2058352016 hasRelatedWork W2042272536 @default.
- W2058352016 hasRelatedWork W2057706260 @default.
- W2058352016 hasRelatedWork W2329387523 @default.
- W2058352016 hasRelatedWork W2417902090 @default.
- W2058352016 hasRelatedWork W2767629825 @default.
- W2058352016 hasRelatedWork W3134784103 @default.
- W2058352016 hasRelatedWork W3202079152 @default.
- W2058352016 hasRelatedWork W4372227493 @default.
- W2058352016 hasVolume "180" @default.
- W2058352016 isParatext "false" @default.
- W2058352016 isRetracted "false" @default.
- W2058352016 magId "2058352016" @default.
- W2058352016 workType "article" @default.