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• W2058358001 endingPage "508" @default.
• W2058358001 startingPage "504" @default.
• W2058358001 abstract "Homopyrimidine oligonucleotides bind to the major groove of a complementary homopyrimidine.homopurine stretch by triple helix formation. The bla gene from transposon Tn3 contains a homopyrimidine.homopurine sequence of 13 base pairs located just downstream of the RNA polymerase binding site. A 13-mer homopyrimidine oligonucleotide targeted to this sequence was tested for its effect on transcription of the bla gene in vitro. We show that the consequence of triple helix formation in front of the Escherichia coli RNA polymerase-promoter complex is to block the holoenzyme at its start site during a period that is dependent on temperature. The temperature dependence of transcription inhibition shows a direct correlation between this effect and the stabilization of the triple helix. Substitution of 5-methylcytosine to cytosine in the 13-mer oligonucleotide enhances triplex stability and transcription inhibition. Transcription inhibition by this synthetic repressor was also confirmed by footprinting studies demonstrating its specificity of action. The 13-mer oligonucleotide containing a psoralen derivative covalently linked to its 5' end shows an irreversible and specific inhibition of transcription initiation after exposure to light of wavelength greater than 310 nm." @default.
• W2058358001 created "2016-06-24" @default.
• W2058358001 creator A5066290057 @default.
• W2058358001 creator A5075343140 @default.
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• W2058358001 date "1992-01-15" @default.
• W2058358001 modified "2023-10-16" @default.
• W2058358001 title "Specific inhibition of transcription by triple helix-forming oligonucleotides." @default.
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• W2058358001 doi "https://doi.org/10.1073/pnas.89.2.504" @default.
• W2058358001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/48267" @default.
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