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- W2058360779 abstract "A novel curcumin mimic library (14a–14h and 15a–15h) possessing variously substituted benzimidazole groups was synthesized through the aldol reaction of (E)-4-(4-hydroxy-3-methoxyphenyl)but-3-en-2-one (7) or (E)-4-(3-hydroxy-4-methoxyphenyl)but-3-en-2-one (13) with diversely substituted benzimidazolyl-2-carbaldehyde (12a–12h). The MTT assay of the cancer cells MCF-7, SH-SY5Y, HEP-G2, and H460 showed that compound 14c with IC50 of 1.0 and 1.9 μM has a strong inhibitory effect on the growth of SH-SY5Y and Hep-G2 cells, respectively, and that compound 15h with IC50 of 1.9 μM has a strong inhibitory effect on the growth of MCF-7 cancer cells." @default.
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- W2058360779 date "2012-01-01" @default.
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- W2058360779 title "Synthesis of substituted benzimidazolyl curcumin mimics and their anticancer activity" @default.
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- W2058360779 doi "https://doi.org/10.1016/j.bmcl.2011.12.074" @default.
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