FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058361908> ?p ?o ?g. }

• W2058361908 endingPage "6602" @default.
• W2058361908 startingPage "6597" @default.
• W2058361908 abstract "To initiate transcription from specific promoters, the bacterial RNA polymerase (RNAP) core enzyme must associate with the initiation factor sigma, which contains determinants that allow sequence-specific interactions with promoter DNA. Most bacteria contain several sigma factors, each of which directs recognition of a distinct set of promoters. A large and diverse family of proteins known as anti-sigma factors regulates promoter utilization by targeting specific sigma factors. The founding member of this family is the AsiA protein of bacteriophage T4. AsiA specifically targets the primary sigma factor in Escherichia coli, sigma(70), and inhibits transcription from the major class of sigma(70)-dependent promoters. AsiA-dependent transcription inhibition has been attributed to a well-documented interaction between AsiA and conserved region 4 of sigma(70). Here, we establish that efficient AsiA-dependent transcription inhibition also requires direct protein-protein contact between AsiA and the RNAP core. In particular, we demonstrate that AsiA contacts the flap domain of the RNAP beta-subunit (the beta-flap). Our findings support the emerging view that the beta-flap is a target site for regulatory proteins that affect RNAP function during all stages of the transcription cycle." @default.
• W2058361908 created "2016-06-24" @default.
• W2058361908 creator A5015756624 @default.
• W2058361908 creator A5027321631 @default.
• W2058361908 creator A5091412976 @default.
• W2058361908 date "2009-04-21" @default.
• W2058361908 modified "2023-09-23" @default.
• W2058361908 title "The bacteriophage T4 AsiA protein contacts the β-flap domain of RNA polymerase" @default.
• W2058361908 cites W1543804839 @default.
• W2058361908 cites W1581263435 @default.
• W2058361908 cites W1598239857 @default.
• W2058361908 cites W1784080967 @default.
• W2058361908 cites W1963558018 @default.
• W2058361908 cites W1967862819 @default.
• W2058361908 cites W1981112331 @default.
• W2058361908 cites W1982553515 @default.
• W2058361908 cites W1983012964 @default.
• W2058361908 cites W1990898344 @default.
• W2058361908 cites W1997268928 @default.
• W2058361908 cites W1998189623 @default.
• W2058361908 cites W1998816823 @default.
• W2058361908 cites W1999130463 @default.
• W2058361908 cites W2002488318 @default.
• W2058361908 cites W2010742082 @default.
• W2058361908 cites W2011996370 @default.
• W2058361908 cites W2020404753 @default.
• W2058361908 cites W2038750534 @default.
• W2058361908 cites W2042586799 @default.
• W2058361908 cites W2042596462 @default.
• W2058361908 cites W2043098161 @default.
• W2058361908 cites W2045902027 @default.
• W2058361908 cites W2046456357 @default.
• W2058361908 cites W2048581247 @default.
• W2058361908 cites W2050090277 @default.
• W2058361908 cites W2052377115 @default.
• W2058361908 cites W2053609834 @default.
• W2058361908 cites W2055506322 @default.
• W2058361908 cites W2061638026 @default.
• W2058361908 cites W2071090620 @default.
• W2058361908 cites W2075716499 @default.
• W2058361908 cites W2075743405 @default.
• W2058361908 cites W2076399803 @default.
• W2058361908 cites W2086269772 @default.
• W2058361908 cites W2086976399 @default.
• W2058361908 cites W2089631335 @default.
• W2058361908 cites W2092433611 @default.
• W2058361908 cites W2093224063 @default.
• W2058361908 cites W2094042154 @default.
• W2058361908 cites W2107870109 @default.
• W2058361908 cites W2111014820 @default.
• W2058361908 cites W2111742728 @default.
• W2058361908 cites W2112665912 @default.
• W2058361908 cites W2116844374 @default.
• W2058361908 cites W2139972745 @default.
• W2058361908 cites W2147057508 @default.
• W2058361908 cites W2159491669 @default.
• W2058361908 cites W2160789395 @default.
• W2058361908 cites W2165730924 @default.
• W2058361908 cites W2165894602 @default.
• W2058361908 cites W2170825389 @default.
• W2058361908 cites W2171578748 @default.
• W2058361908 cites W475563431 @default.
• W2058361908 doi "https://doi.org/10.1073/pnas.0812832106" @default.
• W2058361908 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2672554" @default.
• W2058361908 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19366670" @default.
• W2058361908 hasPublicationYear "2009" @default.
• W2058361908 type Work @default.
• W2058361908 sameAs 2058361908 @default.
• W2058361908 citedByCount "19" @default.
• W2058361908 countsByYear W20583619082012 @default.
• W2058361908 countsByYear W20583619082013 @default.
• W2058361908 countsByYear W20583619082014 @default.
• W2058361908 countsByYear W20583619082016 @default.
• W2058361908 countsByYear W20583619082017 @default.
• W2058361908 countsByYear W20583619082019 @default.
• W2058361908 countsByYear W20583619082020 @default.
• W2058361908 countsByYear W20583619082023 @default.
• W2058361908 crossrefType "journal-article" @default.
• W2058361908 hasAuthorship W2058361908A5015756624 @default.
• W2058361908 hasAuthorship W2058361908A5027321631 @default.
• W2058361908 hasAuthorship W2058361908A5091412976 @default.
• W2058361908 hasBestOaLocation W20583619082 @default.
• W2058361908 hasConcept C101762097 @default.
• W2058361908 hasConcept C104292427 @default.
• W2058361908 hasConcept C104317684 @default.
• W2058361908 hasConcept C121332964 @default.
• W2058361908 hasConcept C138885662 @default.
• W2058361908 hasConcept C150194340 @default.
• W2058361908 hasConcept C179926584 @default.
• W2058361908 hasConcept C2776441376 @default.
• W2058361908 hasConcept C2776449523 @default.
• W2058361908 hasConcept C2778049214 @default.
• W2058361908 hasConcept C41895202 @default.
• W2058361908 hasConcept C47319516 @default.
• W2058361908 hasConcept C54355233 @default.
• W2058361908 hasConcept C547475151 @default.
• W2058361908 hasConcept C62520636 @default.
• W2058361908 hasConcept C67705224 @default.

• next