Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058363411> ?p ?o ?g. }
- W2058363411 endingPage "4167" @default.
- W2058363411 startingPage "4161" @default.
- W2058363411 abstract "Abstract Purpose: Transcriptional profiling showed decreased expression of gastrokine 1 (GKN1) and the related trefoil factor interacting protein (TFIZ1/GKN2) in Helicobacter pylori infection. Decreased GKN1 and GKN2 mRNA expression has been reported in gastric adenocarcinoma. We have examined GKN1 and GKN2 protein expression in a large gastric cancer series, correlated expression with tumor subtype, and evaluated their utility as prognostic biomarkers. Experimental Design: GKN1, GKN2, and the trefoil factors TFF1 and TFF3 were examined in tissue microarrays from 155 distal gastric adenocarcinomas. Immunohistochemical expression was correlated with clinical outcome. GKN1 and GKN2 expression was measured by real-time PCR and Western analysis in samples of gastric cancer and adjacent nonneoplastic mucosa. Results: GKN1 was lost in 78% of diffuse and 42% of intestinal cancers (P < 0.0001, diffuse versus intestinal). GKN2 expression was lost in 85% of diffuse and 54% of intestinal type cancers (P < 0.002). GKN1 and GKN2 down-regulation were confirmed by Western and real-time PCR analysis. Loss of either protein was associated with significantly worse outcome in intestinal-type tumors by univariate analysis; and GKN2 loss remained a predictor of poor outcome in multivariate analysis (P < 0.033). TFF1 was lost in >70%, and TFF3 was expressed in ∼50% of gastric cancers. Conclusions: Loss of GKN1 and GKN2 expression occurs frequently in gastric adenocarcinomas, especially in the diffuse subtype. GKN1 and GKN2 loss are associated with shorter overall survival in the intestinal subtype." @default.
- W2058363411 created "2016-06-24" @default.
- W2058363411 creator A5004706455 @default.
- W2058363411 creator A5026612940 @default.
- W2058363411 creator A5030502605 @default.
- W2058363411 creator A5031928873 @default.
- W2058363411 creator A5036318503 @default.
- W2058363411 creator A5039081630 @default.
- W2058363411 creator A5043673378 @default.
- W2058363411 creator A5049228445 @default.
- W2058363411 creator A5055073191 @default.
- W2058363411 creator A5055445732 @default.
- W2058363411 creator A5065415336 @default.
- W2058363411 date "2008-07-01" @default.
- W2058363411 modified "2023-09-26" @default.
- W2058363411 title "Decreased Expression of Gastrokine 1 and the Trefoil Factor Interacting Protein TFIZ1/GKN2 in Gastric Cancer: Influence of Tumor Histology and Relationship to Prognosis" @default.
- W2058363411 cites W164051564 @default.
- W2058363411 cites W1965883445 @default.
- W2058363411 cites W1969432263 @default.
- W2058363411 cites W1969875009 @default.
- W2058363411 cites W1974291733 @default.
- W2058363411 cites W1982282184 @default.
- W2058363411 cites W1985999564 @default.
- W2058363411 cites W1991137546 @default.
- W2058363411 cites W2000122975 @default.
- W2058363411 cites W2003781437 @default.
- W2058363411 cites W2018466710 @default.
- W2058363411 cites W2019572861 @default.
- W2058363411 cites W2030093463 @default.
- W2058363411 cites W2043620021 @default.
- W2058363411 cites W2051834296 @default.
- W2058363411 cites W2061130074 @default.
- W2058363411 cites W2070566005 @default.
- W2058363411 cites W2072095492 @default.
- W2058363411 cites W2075705783 @default.
- W2058363411 cites W2076509340 @default.
- W2058363411 cites W2079985291 @default.
- W2058363411 cites W2090178785 @default.
- W2058363411 cites W2097795604 @default.
- W2058363411 cites W2100172636 @default.
- W2058363411 cites W2112817649 @default.
- W2058363411 cites W2113008513 @default.
- W2058363411 cites W2123549318 @default.
- W2058363411 cites W2140481064 @default.
- W2058363411 cites W2141054539 @default.
- W2058363411 cites W2144143479 @default.
- W2058363411 cites W2162685028 @default.
- W2058363411 cites W2338576041 @default.
- W2058363411 cites W2406676844 @default.
- W2058363411 cites W4245344895 @default.
- W2058363411 doi "https://doi.org/10.1158/1078-0432.ccr-07-4381" @default.
- W2058363411 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2572195" @default.
- W2058363411 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18593995" @default.
- W2058363411 hasPublicationYear "2008" @default.
- W2058363411 type Work @default.
- W2058363411 sameAs 2058363411 @default.
- W2058363411 citedByCount "88" @default.
- W2058363411 countsByYear W20583634112012 @default.
- W2058363411 countsByYear W20583634112013 @default.
- W2058363411 countsByYear W20583634112014 @default.
- W2058363411 countsByYear W20583634112015 @default.
- W2058363411 countsByYear W20583634112016 @default.
- W2058363411 countsByYear W20583634112017 @default.
- W2058363411 countsByYear W20583634112018 @default.
- W2058363411 countsByYear W20583634112019 @default.
- W2058363411 countsByYear W20583634112020 @default.
- W2058363411 countsByYear W20583634112021 @default.
- W2058363411 countsByYear W20583634112022 @default.
- W2058363411 crossrefType "journal-article" @default.
- W2058363411 hasAuthorship W2058363411A5004706455 @default.
- W2058363411 hasAuthorship W2058363411A5026612940 @default.
- W2058363411 hasAuthorship W2058363411A5030502605 @default.
- W2058363411 hasAuthorship W2058363411A5031928873 @default.
- W2058363411 hasAuthorship W2058363411A5036318503 @default.
- W2058363411 hasAuthorship W2058363411A5039081630 @default.
- W2058363411 hasAuthorship W2058363411A5043673378 @default.
- W2058363411 hasAuthorship W2058363411A5049228445 @default.
- W2058363411 hasAuthorship W2058363411A5055073191 @default.
- W2058363411 hasAuthorship W2058363411A5055445732 @default.
- W2058363411 hasAuthorship W2058363411A5065415336 @default.
- W2058363411 hasBestOaLocation W20583634111 @default.
- W2058363411 hasConcept C104317684 @default.
- W2058363411 hasConcept C121608353 @default.
- W2058363411 hasConcept C126322002 @default.
- W2058363411 hasConcept C142724271 @default.
- W2058363411 hasConcept C150194340 @default.
- W2058363411 hasConcept C193270364 @default.
- W2058363411 hasConcept C203014093 @default.
- W2058363411 hasConcept C204232928 @default.
- W2058363411 hasConcept C2777116383 @default.
- W2058363411 hasConcept C2781182431 @default.
- W2058363411 hasConcept C502942594 @default.
- W2058363411 hasConcept C54355233 @default.
- W2058363411 hasConcept C57742111 @default.
- W2058363411 hasConcept C71924100 @default.
- W2058363411 hasConcept C86803240 @default.
- W2058363411 hasConceptScore W2058363411C104317684 @default.
- W2058363411 hasConceptScore W2058363411C121608353 @default.