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- W2058366263 abstract "The neurotransmitter GABA regulates many aspects of inhibitory synapse development. We tested the hypothesis that GABAA receptors (GABAARs) work together with the synaptic adhesion molecule neuroligin 2 (NL2) to regulate synapse formation in different subcellular compartments. We investigated mice (“γ2 knockdown mice”) with an engineered allele of the GABAAR γ2 subunit gene which produced a mosaic expression of synaptic GABAARs in neighboring neurons, causing a strong imbalance in synaptic inhibition. Deletion of the γ2 subunit did not abolish synapse formation or the targeting of NL2 to distinct types of perisomatic and axo-dendritic contacts. Thus synaptic localization of NL2 does not require synaptic GABAARs. However, loss of the γ2 subunit caused a selective decrease in the number of axo-dendritic synapses on cerebellar Purkinje cells and cortical pyramidal neurons, whereas perisomatic synapses were not significantly affected. Notably, γ2-positive cells had increased axo-dendritic innervation compared with both γ2-negative and wild-type counterparts. Moreover heterologous synapses on spines, that are found after total deletion of GABAARs from all Purkinje cells, were rare in cerebella of γ2 knockdown mice. These findings reveal a selective role of γ2 subunit-containing GABAARs in regulating synapse development in distinct subcellular compartments, and support the hypothesis that the refinement of axo-dendritic synapses is regulated by activity-dependent competition between neighboring neurons." @default.
- W2058366263 created "2016-06-24" @default.
- W2058366263 creator A5020100632 @default.
- W2058366263 creator A5023949437 @default.
- W2058366263 creator A5029332361 @default.
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- W2058366263 creator A5072852389 @default.
- W2058366263 creator A5083658003 @default.
- W2058366263 creator A5088371300 @default.
- W2058366263 date "2013-02-14" @default.
- W2058366263 modified "2023-09-27" @default.
- W2058366263 title "Synaptic Competition Sculpts the Development of GABAergic Axo-Dendritic but Not Perisomatic Synapses" @default.
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